The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese

Ng, Man Wai; Zhou, Gangqiao; Chong, Wai Po; Lee, Loretta Wing Yan; Law, Helen K. W.; Zhang, Hongxing; Wong, Wilfred Hing Sang; Fok, Susanna Fung Shan; Zhai, Yun; Yung, R; Chow, Eudora Y.D.; Au, Ka Leung; Chan, Eric; Lim, Wilina; Peiris, J. S. Malik; He, Fuchu; Lau, Yu Lung

doi:10.1186/1471-2334-7-50

Cited by 39 publications

(31 citation statements)

References 20 publications

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“…CXCL10 variant namely rs8878, located at the 3 0 -UTR, is believed to affect RNA-binding protein important for efficient translation of this gene via RNA stabilization [28]. It has been associated with autoimmune diseases like type-I diabetes [29], and severe acute respiratory syndrome amongst Chinese [30]. As for another SNP with significant association, rs4859584, a search in dbSNP though revealed no known disease association was reported [31].…”

Section: Discussionmentioning

confidence: 99%

Common variants of chemokine receptor gene CXCR3 and its ligands CXCL10 and CXCL11 associated with vascular permeability of dengue infection in peninsular Malaysia

et al. 2015

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Dengue causes significantly more human disease than any other arboviruses. It causes a spectrum of illness, ranging from mild self-limited fever, to severe and fatal dengue hemorrhagic fever, as evidenced by vascular leakage and multifactorial hemostatic abnormalities. There is no specific treatment available till date. Evidence shows that chemokines CXCL10, CXCL11 and their receptor CXCR3 are involved in severity of dengue, but their genetic association with the susceptibility of vascular leakage during dengue infection has not been reported. We genotyped 14 common variants of these candidate genes in 176 patients infected with dengue. rs4859584 and rs8878 (CXCL10) were significantly associated with vascular permeability of dengue infection (P<0.05); while variants of CXCL11 showed moderate significance of association (P=0.0527). Haplotype blocks were constructed for genes CXCL10 and CXCL11 (5 and 7 common variants respectively). Haplotype association tests performed revealed that, "CCCCA" of gene CXCL10 and "AGTTTAC" of CXCL11 were found to be significantly associated with vascular leakage (P=0.0154 and 0.0366 respectively). In summary, our association study further strengthens the evidence of the involvement of CXCL10 and CXCL11 in the pathogenesis of dengue infection.

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Section: Discussionmentioning

confidence: 99%

Common variants of chemokine receptor gene CXCR3 and its ligands CXCL10 and CXCL11 associated with vascular permeability of dengue infection in peninsular Malaysia

et al. 2015

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“…The G allele elevates promoter activity and thus increases the expression of RANTES in T-cells, which can lead to cell damage and organ dysfunction. In another study of the association of RANTES-28 polymorphisms with susceptibility to SARs in Hong Kong and Beijing citizens, individuals having G alleles were shown to have a 3-fold increased risk of developing the disease when compared to individuals possessing C alleles (Ng et al, 2007). The high level of RANTES is believed to predispose individuals with the G allele to SARs.…”

Section: Discussionmentioning

confidence: 99%

Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population

Lh¹,

Kee²,

Hl³

et al. 2011

Genet. Mol. Res.

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ABSTRACT. Regulated on activation, normal T-cell expressed and secreted (RANTES) and stromal cell-derived factor 1 (SDF-1) are members of the CC-and CXC-chemokine families, respectively. Both genes have been postulated to be involved in the pathogenesis of systemic lupus erythematosus (SLE). We analyzed position 28 of the RANTES gene promoter region, as well as the SNP observed in the 3' UTR of the SDF-1 gene at position 801, in 130 patients presenting SLE at the Malaya University Medical Centre. Screening of 130 healthy volunteer controls using RFLP was also performed. RANTES-28 polymorphism analysis showed no significant (P = 0.3520) relationship, even though homozygous C/C was more frequent in SLE patients (OR = 1.4183) and heterozygous C/G was more frequent in healthy controls (OR = 0.7051). There were no significant (P = 0.2650) associations between A/A (OR = 0.783), G/G (OR = 1.5914) and G/A (OR = 0.8289) genotypes in the SDF-1 gene polymorphism with SLE. We conclude that there is no significant association of RANTES-28 and SDF-1 gene polymorphisms and occurrence of SLE in Malaysia.

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“…Reproduction of these findings has been difficult due to small sample sizes and limitations of access of the samples (153,163). More recently, IL-12 RB1, Rantes, and IFN-␥ polymorphisms were linked to SARS disease severity (16,88). Undoubtedly, more genomic links to disease will be found in the future.…”

Section: Sars-cov and Human Infectionsmentioning

confidence: 99%

Mechanisms of Severe Acute Respiratory Syndrome Pathogenesis and Innate Immunomodulation

Frieman

Baric

2008

Microbiol Mol Biol Rev

106

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SUMMARY The modulation of the immune response is a common practice of many highly pathogenic viruses. The emergence of the highly pathogenic coronavirus severe acute respiratory virus (SARS-CoV) serves as a robust model system to elucidate the virus-host interactions that mediate severe end-stage lung disease in humans and animals. Coronaviruses encode the largest positive-sense RNA genome of ∼30 kb, encode a variety of replicase and accessory open reading frames that are structurally unique, and encode novel enzymatic functions among RNA viruses. These viruses have broad or specific host ranges, suggesting the possibility of novel strategies for targeting and regulating host innate immune responses following virus infection. Using SARS-CoV as a model, we review the current literature on the ability of coronaviruses to interact with and modify the host intracellular environment during infection. These studies are revealing a rich set of novel viral proteins that engage, modify, and/or disrupt host cell signaling and nuclear import machinery for the benefit of virus replication.

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The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese

Abstract: Background: Chemokines play important roles in inflammation and antiviral action. We examined whether polymorphisms of RANTES, IP-10 and Mig affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).

Cited by 39 publications

References 20 publications

Common variants of chemokine receptor gene CXCR3 and its ligands CXCL10 and CXCL11 associated with vascular permeability of dengue infection in peninsular Malaysia

Common variants of chemokine receptor gene CXCR3 and its ligands CXCL10 and CXCL11 associated with vascular permeability of dengue infection in peninsular Malaysia

Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population

Mechanisms of Severe Acute Respiratory Syndrome Pathogenesis and Innate Immunomodulation

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