The association of periodontal disease with the complications of diabetes mellitus. A systematic review

Nguyen, Anh Thi Mai; Akhter, Rahena; Garde, Siddharth; Scott, Carolyn D.; Twigg, Stephen M.; Colagiuri, Stephen; Ajwani, Shilpi; Eberhard, Jörg

doi:10.1016/j.diabres.2020.108244

Cited by 81 publications

(60 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Given that the oral cave is the gateway for these substances into our body, knowledge of the effects generated by agents favoring glycative stress is important in order to prevent oral tissues damage. Similarly, MG and MG-derived AGEs may be important contributing factors to the dental pulp pain that often appears in diabetic patients (diabetic odontalgia) [ 25 , 26 ], being circulating and tissue MG levels very higher in this human metabolic pathology [ 50 ]. These high levels of MG and MG-AGEs could even be responsible of the failure rate of some treatments used for curing oral cave diseases such as apical periodontitis particularly evident in patients with diabetes [ 51 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, some in vivo observations have pointed out the accumulation of MG in some biological fluids from the gingival crevicular fluid of chronic periodontitis patients [ 20 ] that can also be conveyed by bacterial infections [ 21 ], dietary compounds [ 22 ], and cigarette smoke or aerosols from nicotine delivery systems (NDS) (Electronic Cigarette and Heat-not-burn tobacco product IQOS) [ 23 , 24 ]. Notably, numerous clinical and experimental studies have highlighted the presence of a strong association between periodontitis, which represents the most common pathology of the oral cave in the adult population, and some systemic diseases, in particular, diabetes and obesity [ 25 , 26 ], which, as mentioned before, are characterized by increased levels of MG and MG-derived “glycative stress” onset.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Methylglyoxal-Dependent Glycative Stress Is Prevented by the Natural Antioxidant Oleuropein in Human Dental Pulp Stem Cells through Nrf2/Glo1 Pathway

et al. 2021

View full text Add to dashboard Cite

Methylglyoxal (MG) is a potent precursor of glycative stress (abnormal accumulation of advanced glycation end products, AGEs), a relevant condition underpinning the etiology of several diseases, including those of the oral cave. At present, synthetic agents able to trap MG are known; however, they have never been approved for clinical use because of their severe side effects. Hence, the search of bioactive natural scavengers remains a sector of strong research interest. Here, we investigated whether and how oleuropein (OP), the major bioactive component of olive leaf, was able to prevent MG-dependent glycative stress in human dental pulp stem cells (DPSCs). The cells were exposed to OP at 50 µM for 24 h prior to the administration of MG at 300 µM for additional 24 h. We found that OP prevented MG-induced glycative stress and DPSCs impairment by restoring the activity of Glyoxalase 1 (Glo1), the major detoxifying enzyme of MG, in a mechanism involving the redox-sensitive transcription factor Nrf2. Our results suggest that OP holds great promise for the development of preventive strategies for MG-derived AGEs-associated oral diseases and open new paths in research concerning additional studies on the protective potential of this secoiridoid.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Methylglyoxal-Dependent Glycative Stress Is Prevented by the Natural Antioxidant Oleuropein in Human Dental Pulp Stem Cells through Nrf2/Glo1 Pathway

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Periodontitis is a type of chronic, progressive, and infectious disease of periodontal supporting tissues predominantly caused by local irritating factors, such as plaque biofilms. Periodontitis has become one of the most common causes of tooth loss [1], being related to systemic diseases, including diabetes [2][3][4], cardiovascular diseases [5], hypertension [6], chronic kidney disease [7], chronic liver disease [8], peptic ulcers [9] and breast cancer [10].…”

Section: Introductionmentioning

confidence: 99%

Effects of statins on cytokines levels in gingival crevicular fluid and saliva and on clinical periodontal parameters of middle-aged and elderly patients with type 2 diabetes mellitus

Zhang

Chen

et al. 2021

PLoS ONE

View full text Add to dashboard Cite

Objective To analyze the effect of statins on cytokines levels in gingival crevicular fluid (GCF) and saliva and on clinical periodontal parameters of middle-aged and elderly patients with type 2 diabetes mellitus (T2DM). Methods Systemically healthy controls (C group, n = 62), T2DM patients not taking statins (D group, n = 57) and T2DM patients taking statins (S group, n = 24) were recruited. In each group, subjects (40–85 years) were subclassified into the h (periodontal health)group, the g (gingivitis)group or the p (periodontitis) group according to different periodontal conditions. 17 cytokines in gingival crevicular fluid (GCF) and saliva samples of each subject were measured utilizing the Luminex technology kit. Further, HbA1c (glycated hemoglobin), FPG (fasting plasma glucose), PD (probing depth), CAL (clinical attachment level), BOP (bleeding on probing), GI (gingival index) and PI (periodontal index) were recorded. Data distribution was tested through the Shapiro-Wilk test, upon which the Kruskal-Wallis test was applied followed by Mann-Whitney U test and Bonferroni’s correction. Results Levels of IFN-γ, IL-5, IL-10 and IL-13 in the saliva of the Dh group were significantly lower than those in the Ch group, while factor IL-4 was higher (p<0.05). Levels of MIP-3α, IL-7 and IL-2 in GCF of the Dh group were considerably higher than those in the Ch group (p<0.05), while that of IL-23 was considerably lower. Compared with the Cg group, levels of IFN-γ, IL-4, IL-5, IL-6, IL-10 and IL-13 were significantly lower in the saliva of the Dg group (p<0.05). Lower levels of IFN-γ, IL-5 and IL-10 were detected in the Sg group than those in the Cg group (p<0.05). At the same time, levels of IL-1β, IL-6, IL-7, IL-13, IL-17, IL-21 and MIP-3α in the gingival crevicular fluid of the Sg group were lower in comparison with the Dg group. In addition, lower levels of IL-4 and higher levels of IL-7 in GCF were identified in the Dg group than those in the Cg group, while in the Sg group, lower levels of IL-4, MIP-1αand MIP-3αwere observed than those in the Cg group (p<0.05). Lower levels of IFN-γ, IL-6, IL-10, IL-13 and I-TAC were found in the Sp group compared with those in the Cp group. The IFN-γ, IL-6 and IL-10 levels were lower in the Dp group than those in the Cp group (p<0.05). Meanwhile, in the Sp group, lower levels of pro-inflammatory factors IFN-γ, IL-1β, IL-2, IL-6, IL-7, IL-21 and TNF-α, in addition to higher levels of anti-inflammatory factors IL-4 and IL-5 in gingival crevicular fluid, were identified than those in the Dp group. Higher levels of IFN-γ,IL-1β,IL-2,IL-7,IL-21 and TNF-α and a lower level of IL-5 in the Dp group were identified than those in the Cp group (p<0.05). Moreover, statins were able to substantially reduce PD in T2DM patients with periodontitis, indicating an obvious influence on the levels of cytokines secreted by Th1 cells, Th2 cells and Th17 cells, as revealed by PCA (principal component analysis). Conclusion Statins are associated with reduced PD and cytokines levels in the GCF and saliva of T2DM patients with periodontitis.

show abstract

“…This inflammatory burden can affect maternal health beyond the oral cavity leading to a low-grade systemic inflammatory status and metabolic disturbances, influencing the course of gestation [6]. There is evidence supporting the association between periodontal inflammation and diabetes [7]. Treating or reducing inflammatory periodontal diseases results in improvements in glycaemic control which in turn can reduce microvascular complications of diabetes [7].…”

Section: Introductionmentioning

confidence: 99%

“…There is evidence supporting the association between periodontal inflammation and diabetes [7]. Treating or reducing inflammatory periodontal diseases results in improvements in glycaemic control which in turn can reduce microvascular complications of diabetes [7].…”

Section: Introductionmentioning

confidence: 99%

Exploratory Efficacy of Calcium-Vitamin D Milk Fortification and Periodontal Therapy on Maternal Oral Health and Metabolic and Inflammatory Profile

et al. 2021

View full text Add to dashboard Cite

In this 2 × 2 factorial, outcome-assessor blinded, feasibility randomised trial we explored the effect of a non-pharmaceutical multi-component intervention on periodontal health and metabolic and inflammatory profiles among pregnant women with periodontitis receiving prenatal care in a Brazilian public health centre. 69 pregnant women (gestational age ≤20 weeks, T0) were randomly allocated into four groups: (1) fortified sachet (vitamin D and calcium) and powdered milk plus periodontal therapy during pregnancy (early PT) (n = 17); (2) placebo sachet and powdered milk plus early PT (n = 15); (3) fortified sachet and powdered milk plus late PT (after delivery) (n = 19); (4) placebo sachet and powdered milk plus late PT (n = 18). Third trimester (T1) and 6–8 weeks postpartum (T2) exploratory outcomes included periodontal health (% sites with bleeding on probing (BOP)), glucose, insulin, C-Reactive Protein, serum calcium and vitamin D. The mean BOP was significantly reduced in the early PT groups, while BOP worsened in the late PT groups. No significant effect of fortification on BOP was observed. Changes in glucose levels and variation on birthweight did not differ among groups This feasibility trial provides preliminary evidence for estimating the minimum clinically important differences for selected maternal outcomes. A large-scale trial to evaluate the interventions’ clinical benefits and cost-effectiveness is warranted.

show abstract

The association of periodontal disease with the complications of diabetes mellitus. A systematic review

Cited by 81 publications

References 31 publications

Methylglyoxal-Dependent Glycative Stress Is Prevented by the Natural Antioxidant Oleuropein in Human Dental Pulp Stem Cells through Nrf2/Glo1 Pathway

Methylglyoxal-Dependent Glycative Stress Is Prevented by the Natural Antioxidant Oleuropein in Human Dental Pulp Stem Cells through Nrf2/Glo1 Pathway

Effects of statins on cytokines levels in gingival crevicular fluid and saliva and on clinical periodontal parameters of middle-aged and elderly patients with type 2 diabetes mellitus

Exploratory Efficacy of Calcium-Vitamin D Milk Fortification and Periodontal Therapy on Maternal Oral Health and Metabolic and Inflammatory Profile

Contact Info

Product

Resources

About