The association of metabolic syndrome and insulin resistance in early-onset androgenetic alopecia in males: A case–control study

Abstract

Background:Men with premature androgenetic alopecia (AGA) are found to be susceptible to cardiovascular diseases, metabolic syndrome (MS), diabetes mellitus and hypertension, and also premature baldness can have a definite negative impact on self-image and self-esteem in these patients. The aim of this study was to assess the strength of association between MS and/or insulin resistance (IR) in males with early-onset AGA.Methods:A total of 50 male patients with premature AGA and equal number of age-matched controls were enrolled in the study. Anthropometric measures, blood pressure, fasting glucose, fasting insulin, high-density lipoprotein cholesterol, and triglycerides were measured for all the participants. Association of IR and MS was evaluated.Results:Most common grade of hair loss was Grade IIIa (32%) of Hamilton–Norwood Scale of hair loss. Five out of 50 cases (10%) and 2 out of 50 controls (4%) had shown association with IR and the difference between the groups was statistically insignificant (P=0.23). Fifteen out of 50 cases (30%) and 4 out of 50 controls had shown association with MS and the difference between the groups was statistically significant (P=0.005).Conclusion:Male patients with early-onset AGA were not associated with IR. MS was associated with male patients with early-onset AGA. The results observed in our study may raise awareness in susceptible individuals that lifestyle changes in early life can reduce the risk of coronary heart diseases in the long term.

Evaluation of Serum Amyloid A3 in Young Adult Males with Early Onset of Androgenic Alopecia

“…In our examination, we found that there were factually critical contrast among patients and controls in BMI, which concurred with the investigation done by [18].…”

“…Androgenetic alopecia in male creating before multi year old enough with at any rate Grade III of Hamilton-Norwood grouping is named as beginning stage or untimely AGA. Men with untimely AGA are seen as vulnerable to cardiovascular maladies, metabolic disorder (MS), diabetes mellitus, hypertension, and furthermore untimely hair loss can have a positive negative effect on the mental self view and confidence in these patients [18].…”

<p>Androgenetic Alopecia: Relationship to Anthropometric Indices, Blood Pressure and Life-Style Habits</p>

“…2 Some studies have claimed that androgenetic alopecia may be associated with hypertension, metabolic syndrome, central obesity and other cardiovascular risk factors. [3][4][5][6][7] For example, it has been shown that body mass index (BMI) of male patients with androgenetic alopecia may be higher than BMI of healthy controls and higher BMI might be correlated with lower level of zinc in hair, which in turn, may have a role in the pathogenesis of androgenetic alopecia. 8 There are other studies that show that moderate or severe androgenetic alopecia may be associated with the combination of high BMI and smoking.…”

Hyperuricemia is associated with androgenetic alopecia in men: A cross‐sectional case‐control study

“…In age-matched control subjects, the correlation between age and hyperuricemia was consistent with that previously reported. 18 Swaroop et al 19 IR has been shown to increase the risk of AGA. 10,11,21 Higher UA levels probably precede IR, 22…”

“…Swaroop et al 19 and Matilainen et al 20 showed a significant relationship between insulin resistance (IR) and early‐onset AGA. However, further pathophysiological mechanisms are still unclear.…”