The association of maternal and neonatal thrombocytopenia in high-risk pregnancies

Kleckner, Howard B.; Giles, Harlan R.; Corrigan, James J.

doi:10.1016/0002-9378(77)90614-7

Cited by 48 publications

(16 citation statements)

References 12 publications

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“…Similar ndings have also been reported by other studies (2,4,18). This is attributed to placental dysfunction and hypoxia which results in impairment of platelet production by several mechanisms such as a) Adherence of thrombocyte to the damaged endothelial region caused by segmental vasospasm and vasodilatation in the placenta of hypertensive mothers (19,20) b) Unde ned factor which leads to DIC which is said to be transported to the baby by the placenta and cause thrombocytopenia in the newborn (19). (c) Depression of megakaryocyte proliferation due to placental hypoxia as a consequence of hypertension (21)…”

Section: Poor Neonatal Granulocyte Production As An Outcome Of Maternsupporting

confidence: 85%

Hematological profile derangement in newborns as an outcome of hypertensive disorders of pregnancy.

Mtali¹,

Chamba²,

Lyimo³

et al. 2019

Preprint

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Objectives This study aimed at determining the changes of hematological parameters in newborns of mothers with HDP compared to normotensive mothers.Results This was a hospital-based comparative cross-sectional study conducted from December 2017 to May 2018. The study groups consisted of 70 normotensives and 73 hypertensive pregnant women as a comparison and index group respectively. The male to female ratio for the newborns was 1:1. Newborns of the hypertensive mothers had a lower birth weight, lower APGAR score and had a lower median gestation age at the time of birth compared to the newborns of normotensive mothers (P < 0001). White blood cell and differential counts were lower in cord blood of the newborns of HDP group than in the normotensive group (P≤0.001). Approximately 50% of newborns of hypertensive mothers had thrombocytopenia. Furthermore, hypertensive disorders of pregnancy were found to independently predict neutropenia [OR=6 (2.1 – 19.4), p<0.05] and thrombocytopenia [OR=4.3(1.7 – 11.1), p<0.001] in the newborns.

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Section: Poor Neonatal Granulocyte Production As An Outcome Of Maternsupporting

confidence: 85%

Hematological profile derangement in newborns as an outcome of hypertensive disorders of pregnancy.

Mtali¹,

Chamba²,

Lyimo³

et al. 2019

Preprint

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“…[1][2][3][4][5][6] Neonatal thrombocytopenia is observed in 26% to 47% of infants who are delivered to mothers with preeclampsia complicated with hemolysis, elevated liver enzymes, and low platelets syndrome. [7][8][9][10][11] This abnormality affects the long-term outcome when extreme prematurity or intrapartum asphyxia is coexistent. 12 Several studies have demonstrated decreased circulating vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF) levels during preeclampsia, even before onset.…”

mentioning

confidence: 99%

Excess Soluble fms-Like Tyrosine Kinase 1 and Low Platelet Counts in Premature Neonates of Preeclamptic Mothers

Tsao

Wei

et al. 2005

Pediatrics

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“…Infants of preeclamptic mothers may share these coagulation disorders. Neonatal thrombocytopenia is observed in 26-47% of infants delivered to mother with pregnancy-induced hypertension (PIH) complicated with hemolysis, elevated liver enzymes, and low platelet levels (HEELP) syndrome [1][2][3][4][5]. This abnormality impacts the long-term outcome if extreme prematurity or intrapartum asphyxia is coexistent [6].…”

Section: Introductionmentioning

confidence: 99%

The Thrombopoietin Level in the Cord Blood in Premature Infants Born to Mothers with Pregnancy-Induced Hypertension

Tsao

Teng²,

Chou³

et al. 2002

Neonatology

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Objectives: To investigate the level of thrombopoietin in the cord blood of preterm infants, and its relationship with neonatal platelet count and pregnancy-induced hypertension. Study Method: Thrombopoietin levels in the cord blood of preterm neonates, with or without maternal pregnancy-induced hypertension, were measured by enzmye-linked immunosorbent assay. Results: The platelet count was significantly lower in very low birth weight infants, infants with maternal pregnancy-induced hypertension, and infants with maternal thrombocytopenia. Neonatal thrombocytopenia was associated with maternal pregnancy-induced hypertension and very low birth weight. The neonatal platelet count was correlated significantly with the birth weight and the maternal platelet count. There was no difference in the cord blood level of thrombopoietin between infants born to mothers with pregnancy-induced hypertension and those without. No correlation was found between the thrombopoietin level and the neonatal platelet count. A positive correlation between the cord blood thrombopoietin and the maternal platelet count was identified. Conclusion: Maternal pregnancy-induced hypertension and very low birth weight were significantly associated with thrombocytopenia in premature infants, which cannot be explained by decreased thrombopoietin level.

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The association of maternal and neonatal thrombocytopenia in high-risk pregnancies

Cited by 48 publications

References 12 publications

Hematological profile derangement in newborns as an outcome of hypertensive disorders of pregnancy.

Hematological profile derangement in newborns as an outcome of hypertensive disorders of pregnancy.

Excess Soluble fms-Like Tyrosine Kinase 1 and Low Platelet Counts in Premature Neonates of Preeclamptic Mothers

The Thrombopoietin Level in the Cord Blood in Premature Infants Born to Mothers with Pregnancy-Induced Hypertension

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