Excess Soluble fms-Like Tyrosine Kinase 1 and Low Platelet Counts in Premature Neonates of Preeclamptic Mothers

Tsao, Po‐Nien; Wei, Shu–Chen; Su, Yi-Ning; Chou, Hung-Chieh; Chen, Chien-Yi; Hsieh, Wu‐Shiun

doi:10.1542/peds.2004-2240

Cited by 71 publications

(57 citation statements)

References 35 publications

(53 reference statements)

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“…The cord VEGF levels in this study were increased in the preeclamptic group and support previous findings 35,45,46 that elevated umbilical cord serum VEGF levels might be correlated with the clinical development of preeclampsia. However, reduced cord plasma VEGF levels in preeclampsia are also reported.…”

Section: Discussionsupporting

confidence: 92%

“…However, reduced cord plasma VEGF levels in preeclampsia are also reported. 31,46 Vascular endothelial growth factor (VEGF) is a secreted vascular mitogen that is purportedly specific to endothelial cells and has an important regulatory role in vascular growth in several organ systems during development. 47 It has also been suggested that VEGF may be involved in the regulation of amniotic fluid volume and composition.…”

Section: Discussionmentioning

confidence: 99%

“…51 Some studies have also shown that infants with maternal preeclampsia had higher cord blood sFlt-1 but lower PlGF and VEGF levels. 9,45,46 Levels of angiogenic factors may be regulated differently in the maternal and cord plasma of preeclamptic women. The higher levels of VEGF in cord plasma may indicate increased expression in response to hypoxia to stimulate normal angiogenesis in the fetus.…”

Section: Discussionmentioning

confidence: 99%

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Circulating angiogenic factors and their association with birth outcomes in preeclampsia

et al. 2010

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This study was designed to test the hypothesis that altered angiogenic factors together with increased oxidative stress and reduced docosahexaenoic acid (DHA) levels may be associated with altered birth outcome parameters. To test this hypothesis, levels of plasma vascular endothelial growth factor (VEGF), placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), the oxidative stress marker malondialdehyde (MDA) and fatty acids were estimated in women with preeclampsia and their cord samples and compared with those in normotensive women. The association of these parameters with birth outcome was also examined. Our results show that in preeclamptic women, maternal plasma VEGF and PlGF levels were lower, whereas sFlt-1 levels were higher (Po0.05 for all) than in normotensive women. In contrast, cord plasma VEGF levels were higher (Po0.05) in preeclamptic women, whereas there was no difference in sFlt-1 levels. Plasma DHA levels in both the mother and cord were lower (Po0.05) in the preeclamptic group compared with normotensive women. Maternal plasma sFlt-1 levels were positively (n¼23, r¼0.415, P¼0.039) associated with MDA concentrations in preeclamptic women. Maternal plasma sFlt-1 levels showed a strong negative association with baby weight (n¼37, r¼À0.547, P¼0.001), head circumference (n¼37, r¼À0.472, P¼0.005) and baby chest circumference (n¼37, r¼À0.375, P¼0.032) in the preeclamptic group. Cord plasma sFlt-1 concentrations were negatively associated with cord plasma DHA concentrations (n¼28, r¼À0.552, P¼0.004). This study suggests that dysregulation of angiogenic factors may be associated with maternal oxidative stress. Increased oxidative stress may reduce cord DHA levels and increase sFlt-1 levels, leading to poor birth outcomes in preeclampsia.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Circulating angiogenic factors and their association with birth outcomes in preeclampsia

et al. 2010

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“…Data show higher concentrations of the antiangiogenic protein soluble (s-) endoglin in preeclampsia as well, and in one study, preeclampsia risk was elevated most among women in the highest levels for both s-endoglin and the ratio of sFlt1 to PlGF (142). Recently, reduced cord blood VEGF (143,144) and PlGF (144) and elevated sFlt-1 concentrations were shown in preeclamptic compared with uncomplicated pregnancies (144).…”

Section: Prenatal Risk Factors For Breast Cancer Cancer Epidemiol Biomentioning

confidence: 99%

Exploring the Underlying Hormonal Mechanisms of Prenatal Risk Factors for Breast Cancer: A Review and Commentary

Troisi

Potischman

Hoover

2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Prenatal factors have been hypothesized to influence subsequent breast cancer development. Directly evaluating the associations of in utero exposures with risk, however, presents several methodologic and theoretical challenges, including the long induction period between exposure and disease and the lack of certainty regarding the critical timing of exposure. Indirect evaluation of these associations has been achieved by use of proxies such as gestational and neonatal characteristics. Evidence suggests that preeclampsia is associated with a reduced breast cancer risk, whereas high birth weight and dizygotic twinning seem associated with an increased risk. Asians born in Asia have substantially lower breast cancer risks than women born in the West. Although data thus far are few, what exists is not consistent with a unifying hypothesis for a particular biological exposure (such as estrogens or androgens) during pregnancy as mediating the observed associations between pregnancy factors and breast cancer risk. This suggests that additional studies of prenatal factors should seek to broaden the range of hormones, growth, and other endocrine factors that are evaluated in utero. Once candidate biomarkers are identified, assessing them with respect to breast cancer and with intermediate end points in carcinogenesis should be a priority. In addition, investigations should explore the possibility that in utero exposures may not act directly on the breast, but may alter other physiologic pathways such as hormone metabolism that have their effect on risk later in life. (Cancer Epidemiol Biomarkers Prev 2007;16(9):1700 -12)

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“…Therefore, it is to be noted that impairments to vascular system development may initially occur before preterm birth via IUGR and exposure to an inflammatory and antiangiogenic environment. 25,26 In humans, elastin synthesis in arterial walls peaks toward the end of gestation (near term) and then declines very rapidly after birth. 27,28 Arterial distensibility and elasticity depend largely on the ratio of elastin to the more rigid collagen in arterial walls; therefore, a disruption to elastin synthesis at the end of gestation (such as in the event of preterm birth) may have long-term consequences.…”

Section: Vascularmentioning

confidence: 99%

Preterm Birth and Hypertension Risk

et al. 2014

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Excess Soluble fms-Like Tyrosine Kinase 1 and Low Platelet Counts in Premature Neonates of Preeclamptic Mothers

Abstract: Excess sFlt-1 may play an important role in the development of maternal preeclampsia- induced neonatal thrombocytopenia, and SGA.

Cited by 71 publications

References 35 publications

Circulating angiogenic factors and their association with birth outcomes in preeclampsia

Circulating angiogenic factors and their association with birth outcomes in preeclampsia

Exploring the Underlying Hormonal Mechanisms of Prenatal Risk Factors for Breast Cancer: A Review and Commentary

Preterm Birth and Hypertension Risk

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