Preterm Birth and Hypertension Risk

Sutherland, Megan R.; Bertagnolli, Mariane; Lukaszewski, Marie Amélie; Huyard, Fanny; Yzydorczyk, Catherine; Luu, Thuy Mai; Nuyt, Anne Monique

doi:10.1161/hypertensionaha.113.01276

Cited by 67 publications

(43 citation statements)

References 114 publications

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“…9 Structural and functional changes that mediate programing of hypertension and cardiovascular disorders following preterm birth are still unclear but likely involve multiple organ systems including the vasculature and heart, kidneys and sympathetic nervous system. 13,14 Recent comprehensive vascular phenotyping in people born preterm showed structural macrovascular changes -particularly a narrowing of the aorta -and microvascular dysfunction evident by early adulthood. 15 These long-term changes may, in part, be driven by coassociated perinatal factors such as maternal hypertension and post-…”

Section: Why Are Young Adults Born Preterm At Greater Risk Of Chronicmentioning

confidence: 99%

Preterm birth: risk factor for early-onset chronic diseases

Luu

Katz

Leeson

et al. 2015

CMAJ

Self Cite

107

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Section: Why Are Young Adults Born Preterm At Greater Risk Of Chronicmentioning

confidence: 99%

Preterm birth: risk factor for early-onset chronic diseases

Luu

Katz

Leeson

et al. 2015

CMAJ

Self Cite

107

View full text Add to dashboard Cite

“…14 Phthalates can also have additional, indirect effects on cardiovascular risk, as women exposed to phthalates during pregnancy have been shown to have significantly increased odds of delivering preterm 52 and the link between preterm birth (gestational age) and hypertension risk is clear and well established. 53 In light of this and the potential associated health costs, as evidenced in a recently published analysis on the burden and disease costs of exposure to endocrine disrupting chemicals in the EU, 54 there is a need for increased regulatory consideration and policy initiatives to limit exposure to ubiquitous environmental chemicals with the potential to increase cardiovascular risk.…”

Section: Perspectivesmentioning

confidence: 99%

Association of Exposure to Di-2-Ethylhexylphthalate Replacements With Increased Blood Pressure in Children and Adolescents

Trasande

Attinà

2015

Hypertension

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Phthalates are environmental chemicals widely used in consumer and personal care products. In this study we examined associations of urinary phthalates with blood pressure, triglycerides and lipoproteins in children and adolescents, performing a cross-sectional analysis of a subsample of US children 6–19 years of age who participated in the National Health and Nutrition Examination Survey between the years 2009–2012. We quantified exposure to common environmental phthalates, with a focus on the dietary contaminant di-2-ethylhexylphthalate and two increasingly used replacements, di-isononyl phthalate and di-isodecyl phthalate, based on micromolar concentration of urinary metabolites. We assessed descriptive, univariate and multivariable associations with blood pressure and lipids. Controlling for an array of sociodemographic and behavioral factors, as well as diet and body mass, metabolites of di-2-ethylhexylphthalate , di-isononyl phthalate and di-isodecyl phthalate were associated with higher age-, gender- and height-standardized blood pressure. For each log unit increase in di-isodecyl phthalate metabolites, a 0.105 standard deviation unit increase in systolic blood pressure z score was identified (p=0.004); for di-isononyl phthalate metabolites, a 0.113 standard deviation unit increment was identified (p=0.008). For di-2-ethylhexylphthalate metabolites, a 0.103 standard deviation unit increment (p=0.013) was detected. Metabolites of low molecular weight phthalates commonly found in cosmetics and personal care products showed an association with blood pressure (≥90th percentile) in univariate analysis, but this was no longer significant in our full multivariable model, suggesting specificity. Phthalate metabolites were not associated with triglycerides or high-density lipoproteins. Further, longitudinal studies are needed to confirm these associations, and to assess opportunities for intervention.

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“…Indeed, nephron number at birth has important clinical relevance (25) with critical implications for long-term renal health (2,13,15,31). Subjects born very prematurely, putatively carriers of congenital oligonephronia, have been reported to have a lower glomerular filtration rate and to be more susceptible to develop microalbuminuria (18), increased albuminuria (38), and hypertension (4,21,32,34) in childhood or in adulthood. Nevertheless, is the interindividual variability restricted to nephron number or is it in regard to the different glomerular cell types?…”

mentioning

confidence: 99%

Decreasing podocyte number during human kidney intrauterine development

Crobe

Desogus

Sanna

et al. 2014

American Journal of Physiology-Renal Physiology

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Nephron number at birth has relevant clinical importance with implications for long-term renal health. In recent years, the podocyte depletion hypothesis has emerged as an important concept in kidney pathology. This study was aimed at verifying whether human podocyte number changes significantly during intrauterine life. To this end, 62 subjects with gestational ages ranging from 20 to 41 wk were examined. Kidney sections were stained with hematoxylin and eosin and digitally scanned at ×400 magnification. Subjects were subdivided into fetuses (gestational age≤24 wk, n=5), preterms (gestational age≥25 and ≤36 wk, n=39), and full-term newborns (gestational age≥37 wk, n=18). The average podocyte number of 1,908±645, 1,394±498, and 1,126±256 was, respectively, observed in fetuses, preterms, and full-term newborns. A significant main effect (P=0.0051) of gestational age on podocyte number was observed with a significantly lower number in full-term newborns than in fetuses (P<0.01). Intragroup variability was also observed. We speculate that variations in podocyte number could be correlated with factors such as drugs and maternal diet occurring during intrauterine life. In conclusion, this study shows, for the first time, a decreasing trend in podocyte number during gestation.

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Preterm Birth and Hypertension Risk

Cited by 67 publications

References 114 publications

Preterm birth: risk factor for early-onset chronic diseases

Preterm birth: risk factor for early-onset chronic diseases

Association of Exposure to Di-2-Ethylhexylphthalate Replacements With Increased Blood Pressure in Children and Adolescents

Decreasing podocyte number during human kidney intrauterine development

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