The association of leptin and C-reactive protein with the cardiovascular risk factors and metabolic syndrome score in Taiwanese adults

Chiu, Feng Hsiang; Chuang, Chung Hsun; Li, Wen Cheng; Weng, Yi Ming; Fann, Wen Chih; Lo, Hsiang Yun; Sun, Cheng; Wang, Shih Hao

doi:10.1186/1475-2840-11-40

Cited by 33 publications

(38 citation statements)

References 43 publications

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“…Subcutaneous adipose tissue produces interleukine 6, which increased secretion is associated with increasing BMI and body fat. One of the main effects of IL-6 is induction of hepatic CRP production, which is now known to be an independent, major risk marker of cardiovascular complications (19,20). In our study, overweight and obese Roma males and females show higher plasma levels of TNF-α, IL-6 and CRP compared with Roma respondents with normal weight.…”

Section: Parameterssupporting

confidence: 48%

Biomarkers Associated with Obesity and Overweight in the Roma Population Residing in Eastern Slovakia

Petrášová¹,

Bertková²,

Petrášová³

et al. 2014

Cent Eur J Public Health

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SUMMARYBackground: Obesity and overweight are major contributors to the global burden of chronic diseases and disability in both majority and minority populations.Methods: Data from the cross-sectional population-based HepaMeta study conducted in Slovakia in 2011 were used. The sample comprised a total of 452 Roma. Measurements of special bioactive mediators were taken in final groups consisting of 63 male Roma respondents (mean age = 32.59; SD = 8.63) and 117 female Roma respondents (mean age = 34.55; SD = 8.35). Respondents were divided into three groups: those with normal weight, those with overweight and obese. Values for anthropometric parameters, lipids parameters, C-reactive protein, TNF-α, IL-6, leptin, and adiponectin were determined.Results: 27.6% of examined Roma females and 26.9% of males were overweight. Obesity (BMI > 30.0 kg/m 2 ) appeared in a higher proportion of males (28.8%) compared with female (26.5%). Mean levels of total cholesterol, triacylglycerol and LDL-cholesterol were significantly elevated in the overweight and obese subjects compared to normal-weight Roma respondents. The relation was reversed for HDL-C level, with significantly decreased levels in both male and female obese Roma (p < 0.001). The concentration of adiponectin was significantly lower in obese subjects of both genders versus non-obese (Roma male p < 0.001, Roma female p < 0.05). Plasma levels of leptin, IL-6, hs-CRP as well as TNF-α increased in Roma significantly with increasing BMI.Conclusion: The study is the first one to provide data about selected biomarkers. Results may be useful in predicting obesity and its related diseases in the Roma population from the eastern part of Slovakia.

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Section: Parameterssupporting

confidence: 48%

Biomarkers Associated with Obesity and Overweight in the Roma Population Residing in Eastern Slovakia

Petrášová¹,

Bertková²,

Petrášová³

et al. 2014

Cent Eur J Public Health

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“…While previous studies have shown that there are strong associations between low adiponectin levels and impaired FPG or insulin resistance, independent of age, gender, or BMI [24,29,33,34,39,40], meta-analysis revealed that higher adiponectin levels are associated with a lower risk of type 2 DM [41]. A controversial correlation between plasma leptin and BP and impaired fasting glucose or insulin resistance was published [27-29,40,42], however Wannamethee et al found no association of plasma leptin and blood glucose, BP, and total cholesterol, which was identical to the results of this study and those of Wang et al [28,29]. Controversies about correlations between adiponectin, leptin, and blood glucose might be due to different sample populations, and future studies are necessary to verify these results.…”

Section: Discussionmentioning

confidence: 99%

Comparison of salivary and plasma adiponectin and leptin in patients with metabolic syndrome

Thanakun

Watanabe

Thaweboon

et al. 2014

Diabetol Metab Syndr

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BackgroundThe relationship of saliva with plasma protein levels makes saliva an attractive diagnostic tool. Plasma levels of adiponectin and leptin in healthy individuals or diabetes mellitus patients have been previously reported. Nevertheless, salivary levels of these adipocytokines in patients with metabolic syndrome (MS) have never been investigated. This study was aimed to determine adiponectin and leptin levels in saliva and plasma from patients with metabolic syndrome, and evaluate any correlation of these levels with MS.MethodsForty-six healthy and 82 MS patients were enrolled. Demographic data and blood biochemistries were recorded. Saliva and plasma adiponectin and leptin levels were analyzed by enzyme-linked immunosorbent assay (ELISA).ResultsAdiponectin and leptin were higher in plasma than in saliva (p < .001). Plasma adiponectin was decreased and plasma leptin increased in patients with MS (p < .001). Salivary adiponectin and salivary leptin were not different between healthy subjects and MS patients (p = .619 and p = .523). Correlation between salivary and plasma adiponectin showed significant association (r = .211, p = .018) while salivary and plasma leptin had no correlation (r = -.161, p = .069). Significant correlation was observed between the salivary adiponectin/salivary leptin ratio and plasma adiponectin (r = .371, p < .001), but not with any component of MS. Increased triglyceride and waist circumference were associated with risk of having a low level of plasma adiponectin (OR = 1.009; 95% CI 1.002–1.015 and OR = 1.125; 95% CI 1.029–1.230). For leptin, body mass index and high-density lipoprotein cholesterol (HDL-C) were associated with a high level of plasma leptin (OR = 1.621; 95% CI 1.212–2.168 and OR = .966; 95% CI .938–.996). The OR for MS as predicted by plasma adiponectin was .928 (95% CI .881-.977).ConclusionsThis study showed that salivary adiponectin and leptin do not correlate with MS. Although correlation between salivary and plasma adiponectin was observed, no association with MS was observed. Only plasma adiponectin may be useful for the prediction of MS.

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“…Moreover, a large number of studies have indicated that leptin regulates immune function and cytokine secretion, upregulates C-reactive protein production, and increases oxidative stress in endothelial cells, all of which promote the pathophysiology of atherogenesis including endothelial dysfunction [1,4,47,48]. Indeed, obesity or long-term hyperleptinemia was shown to reduce NO bioavailability of the aortic endothelium mice [13] and rats [12], and to attenuate NO-dependent vasodilation of the coronary artery in dogs [14].…”

Section: Discussionmentioning

confidence: 99%

Leptin is associated with vascular endothelial function in overweight patients with type 2 diabetes

Morioka¹,

Emoto²,

Yamazaki³

et al. 2014

Cardiovasc Diabetol

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BackgroundThe adipocyte-derived hormone leptin plays a key role in the regulation of appetite and body weight. Recent studies have suggested that leptin is also involved in the pathogenesis of obesity-related atherosclerosis and cardiovascular disease. In this study, we investigated the association of plasma leptin levels with vascular endothelial function in lean and overweight patients with type 2 diabetes.MethodsOne hundred seventy-one type 2 diabetic patients, of which 85 were overweight (body mass index (BMI) ≥ 25 kg/m2), were enrolled in this cross-sectional study. Plasma leptin concentrations were measured by enzyme-linked immunosorbent assay. Flow-mediated dilatation (FMD) of the brachial artery was measured to evaluate vascular endothelial function using ultrasound.ResultsNo significant difference in FMD was found between the lean and overweight groups (7.0 ± 3.8% and 6.5 ± 3.6%, respectively; p = 0.354). FMD was negatively correlated with age (r = −0.371, p < 0.001) and serum creatinine levels (r = −0.236, p = 0.030), but positively correlated with BMI (r = 0.330, p = 0.002) and plasma leptin levels (r = 0.290, p = 0.007) in the overweight group. FMD was not associated with any parameters in the lean group. Multiple regression analysis including possible atherosclerotic risk factors revealed that the plasma leptin level (β = 0.427, p = 0.013) was independently associated with FMD in the overweight group (R2 = 0.310, p = 0.025), but not the lean group.ConclusionPlasma leptin levels are associated with vascular endothelial function in overweight patients with type 2 diabetes.

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The association of leptin and C-reactive protein with the cardiovascular risk factors and metabolic syndrome score in Taiwanese adults

Cited by 33 publications

References 43 publications

Biomarkers Associated with Obesity and Overweight in the Roma Population Residing in Eastern Slovakia

Biomarkers Associated with Obesity and Overweight in the Roma Population Residing in Eastern Slovakia

Comparison of salivary and plasma adiponectin and leptin in patients with metabolic syndrome

Leptin is associated with vascular endothelial function in overweight patients with type 2 diabetes

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