The association of human adipose angiotensinogen gene expression with abdominal fat distribution in obesity

Harmelen, V van; Elizalde, Montserrat; Ariapart, Parisa; Bergstedt‐Lindqvist, Susanne; Reynisdottir, Signy; Hoffstedt, Johan; Lundkvist, Inger; Bringman, Sven; Arner, Peter

doi:10.1038/sj.ijo.0801217

Cited by 105 publications

(71 citation statements)

References 26 publications

(16 reference statements)

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“…Wolf et al 22 reported that leptin stimulated renal glomerular endothelial cell proliferation. A recent study showed that human adipose angiotensinogen gene expression was associated with abdominal fat distribution in obesity, 23 and that might have an effect on nephropathy. Moreover, the progression of diabetic nephro- …”

Section: Discussionmentioning

confidence: 99%

Effect of weight loss using formula diet on renal function in obese patients with diabetic nephropathy

et al. 2005

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OBJECTIVE:To evaluate the effect and safety of treatment with low-calorie formula diet on renal function and proteinuria in obese patients with diabetic nephropathy. DESIGN: Prospective study on safety and efficacy of a 4-week low-calorie (11-19 kcal/kg/day) normal-protein (0.9-1.2 g/kg/ day) diet partly supplemented with formula diet. SUBJECTS: In all, 22 obese patients with diabetic nephropathy (BMI: 30.475.3 kg/m 2 , HbA1c: 7.171.4%, serum creatinine: 172.4757.5 mmol/l, urinary protein: 3.372.6 g/day). RESULTS: The mean body weight decreased by 6.273.0 kg. The mean systolic blood pressure, creatinine, blood urea nitrogen, urinary protein, and 8-hydroxydeoxyguanosine decreased significantly by 7.5712.7 mmHg, 41.6723.9 mmol/l, 1.5071.61 mmol/l, 1.871.7 g/day, and 3.173.6 ng/mg creatinine, respectively. No patient had increased serum creatinine and urinary protein. Mean creatinine clearance (40.6717.9 to 46.1714.6 ml/s/1.73 m 2 ) and serum albumin showed no significant changes. Dserum creatinine and Durinary protein correlated with Dbody weight (r ¼ 0.62 and 0.49, respectively) and Dvisceral fat area (r ¼ 0.58 and 0.58, respectively), but did not correlate with Dsystolic blood pressure, Dfasting blood glucose and Dsubcutaneous fat area. CONCLUSION: These results suggested that weight reduction using formula diet might improve renal function and proteinuria safely for a short term in obese patients with diabetic nephropathy.

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Section: Discussionmentioning

confidence: 99%

Effect of weight loss using formula diet on renal function in obese patients with diabetic nephropathy

et al. 2005

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“…Angiotensinogen is cleaved by rennin to angiotensin I and then converted to angiotensin II by angiotensinconverting enzyme in adipose tissue. Thus, angiotensin II is also produced locally in adipose tissue 33 . Angiotensin II induces nicotinamide adenine dinucleotide phosphate NADPH oxidase expression and activation in vascular endothelial cells 34,35 , yielding reactive oxygen species ROS as a product 36,37 .…”

Section: Discussionmentioning

confidence: 99%

“…Systemic oxidative stress, measured by animals 29,30 . Another proposed cause relates to the abundant synthesis and secretion of angiotensinogen by adipose tissue 31,32 , especially visceral tissue 32,33 . Angiotensinogen is cleaved by rennin to angiotensin I and then converted to angiotensin II by angiotensinconverting enzyme in adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

Visceral Fat Accumulation is Associated with Oxidative Stress and Increased Matrix Metalloproteinase-9 Expression in Atherogenic Factor-overlapped Model Rats

Tomita¹,

Iwai²,

Kumai

et al. 2010

Showa Univ J Med Sci

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“…11,12 A mice model with a transgenic human AGT gene had increased AGT expression only in visceral adipose tissue (VAT), including the perirenal depot, after a diet-induced obesity. 13 In the kidney, a localized increase of AGT transcription may lead to an increased local AngII production with systemic effects due to the quantitative influence on tubular sodium re-absorption.…”

Section: Introductionmentioning

confidence: 99%

Angiotensinogen promoter variants influence gene expression in human kidney and visceral adipose tissue

et al. 2009

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Human angiotensinogen (AGT) gene promoter polymorphisms (GÀ217A; AÀ20C; GÀ6A) influence AGT transcription in vitro and have been implicated in the genetics of essential hypertension. We analysed the association among AGT promoter variants and AGT mRNA levels in human kidney and visceral adipose tissue (VAT) in vivo. Samples of kidney and VAT were obtained from 35 consecutive patients undergoing renal surgery. The AGT gene promoter of each patient was sequenced to identify variants. AGT gene expression was studied by real-time PCR TaqMan assay. Clinical data obtained before surgery were also considered in the statistical analysis. Two new polymorphisms at À175 and at À163 were identified. Although AGT expression was significantly higher in VAT than in the kidney, when both variants were present together AGT expression in VAT was about fivefold lower (P ¼ 0.033) than in the wild haplotype. This lower AGT expression in VAT suggests that the proximity and linkage of À175A and À163A variants might destabilize the binding of specific transcription factors to an acute-phase responsive element 3. Among the known AGT promoter variants, only À20C SNP has an important effect on tissue-specific differential AGT expression in the human tissues studied, inducing a 3.8-fold increase in AGT mRNA localized only in the kidney medulla (P ¼ 0.038). The other known polymorphisms (GÀ6A; GÀ217A) were not associated with different levels of AGT expression. Our results support the hypothesis that some human AGT promoter variants influence transcriptional activity in a tissue-specific way in humans.

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The association of human adipose angiotensinogen gene expression with abdominal fat distribution in obesity

Cited by 105 publications

References 26 publications

Effect of weight loss using formula diet on renal function in obese patients with diabetic nephropathy

Effect of weight loss using formula diet on renal function in obese patients with diabetic nephropathy

Visceral Fat Accumulation is Associated with Oxidative Stress and Increased Matrix Metalloproteinase-9 Expression in Atherogenic Factor-overlapped Model Rats

Angiotensinogen promoter variants influence gene expression in human kidney and visceral adipose tissue

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