The association of HLA and immune responses to bovine collagen implants

Vanderveen, Evelyn E.

doi:10.1001/archderm.122.6.650

Cited by 6 publications

(3 citation statements)

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“…Even though it is well known that nonhuman collagen implants are capable of inducing heterologous anticollagen antibodies (Ellingsworth et al, 1986;Trentham, 1986;Vanderveen et al, 1986;Hyder et al, 1992), no evidence exists to associate them with autoimmune diseases related to collagen dermal implants (Singh and Fries, 1994;Lewy, 1994). Furthermore, little is known about porcine collagen implants, as in the case of collagen-PVP.…”

Section: Discussionmentioning

confidence: 99%

Cytokine Expression is Downregulated by Collagen-Polyvinylpyrrolidone in Hypertrophic Scars11The results presented in this work are part of Fernando E. Krötzsch-Gómez’s doctoral dissertation.

Krötzsch-Gómez¹,

Furuzawa‐Carballeda²,

León³

et al. 1998

Journal of Investigative Dermatology

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We evaluated the in situ expression of adhesion molecules (E-selectin and vascular cell-adhesion molecule) and proinflammatory/fibrogenic cytokines (IL-1beta, TNF-alpha, TGF-beta1, and PDGF) in sections of normal skin, hypertrophic scar, and hypertrophic scar previously treated with an irradiated mixture of collagen-polyvinylpyrrolidone and completely resolved. Expression of these proteins was detected by indirect immunoperoxidase staining. The hypertrophic scar group displayed an increased amount of IL-1beta, TNF-alpha, TGF-beta1, and PDGF compared with the normal skin and treated scar groups. Values were statistically significant when cytokines in hypertrophic scar and hypertrophic treated sections were compared. Surprisingly, no differences were detected between normal skin and treated scars. On the other hand, differences in levels of E-selectin and vascular cell-adhesion molecule were not statistically significant between the groups, except for vascular cell-adhesion molecule, which decreased in treated scars. Also, supernatants from fibroblast cultures derived from treated hypertrophic scar, showed a reduction in TGF-beta1 and PDGF expression, although apparently collagen synthesis was not affected. Based on previous data from clinical studies in human dermal fibrosis remodeling, and the results presented here, we suggest that collagen-polyvinylpyrrolidone modulates extracellular matrix turnover, mainly of collagen, because expression levels of IL-1beta, TNF-alpha, TGF-beta1, and PDGF were diminished. We infer that collagen-polyvinylpyrrolidone participation could also modify the inflammatory process observed in hypertrophic scarring, by diminishing the expression of adhesion molecules, as a consequence of lower levels of proinflammatory cytokines, mainly IL-1beta and TNF-alpha.

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Section: Discussionmentioning

confidence: 99%

Cytokine Expression is Downregulated by Collagen-Polyvinylpyrrolidone in Hypertrophic Scars11The results presented in this work are part of Fernando E. Krötzsch-Gómez’s doctoral dissertation.

Krötzsch-Gómez¹,

Furuzawa‐Carballeda²,

León³

et al. 1998

Journal of Investigative Dermatology

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“…An association between responsiveness to collagen implant and HLA major histocompatibility complex loci has been shown by Vanderveen et al [22]: all patients suffering from adverse clinical reactions were lacking the HLA-DR4 antigen, while patients who received multiple bovine collagen injections without adverse clinical reactions were lacking HLA-B5 and HLA-DR5.…”

Section: The Nature Of the Immune Response To Injectable Collagen In mentioning

confidence: 94%

Immunologic Aspects of Bovine Injectable Collagen in Humans

Aragona¹,

D’Urso²,

Marcolongo

1998

European Urology

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“…Associations between responsiveness to other forms of bovine collagen (not collagen implant) and HLA major histocompatibility complex loci have previously been shown 10 . While older studies had shown no such association between HLA loci and responsiveness to bovine collagen implant, 19 a more recent study has shown an increase in the HLA DR2 and DR4 alloantigen frequency in healthy individuals who are responsive to bovine collagen implant 20 . This statistical association is not absolute and does not prove genetic control.…”

Section: The Human Immune Response To Injectable Collagenmentioning

confidence: 95%