The association of HLA and immune responses to bovine collagen implants

Cytokine Expression is Downregulated by Collagen-Polyvinylpyrrolidone in Hypertrophic Scars11The results presented in this work are part of Fernando E. Krötzsch-Gómez’s doctoral dissertation.

“…Even though it is well known that nonhuman collagen implants are capable of inducing heterologous anticollagen antibodies (Ellingsworth et al, 1986;Trentham, 1986;Vanderveen et al, 1986;Hyder et al, 1992), no evidence exists to associate them with autoimmune diseases related to collagen dermal implants (Singh and Fries, 1994;Lewy, 1994). Furthermore, little is known about porcine collagen implants, as in the case of collagen-PVP.…”

Immunologic Aspects of Bovine Injectable Collagen in Humans

“…An association between responsiveness to collagen implant and HLA major histocompatibility complex loci has been shown by Vanderveen et al [22]: all patients suffering from adverse clinical reactions were lacking the HLA-DR4 antigen, while patients who received multiple bovine collagen injections without adverse clinical reactions were lacking HLA-B5 and HLA-DR5.…”

The Immunogenicity of Bovine Collagen Implants

“…Associations between responsiveness to other forms of bovine collagen (not collagen implant) and HLA major histocompatibility complex loci have previously been shown 10 . While older studies had shown no such association between HLA loci and responsiveness to bovine collagen implant, 19 a more recent study has shown an increase in the HLA DR2 and DR4 alloantigen frequency in healthy individuals who are responsive to bovine collagen implant 20 . This statistical association is not absolute and does not prove genetic control.…”