The Immunogenicity of Bovine Collagen Implants

Rahbar, Guita; Moy, Ronald L.

doi:10.1111/j.1524-4725.1993.tb00370.x

Cited by 27 publications

(16 citation statements)

References 22 publications

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“…Interestingly, all gels in which collagen was a component resulted in lymphocyte proliferation. This result is likely due to the human lymphocytes recognizing foreign antigens in the rat‐tail collagen, and becoming stimulated to proliferate 70, 71. Although this proliferation was only minor when compared to the PHA‐P positive control, it highlights the potential for immune reactions to xeno‐sourced hydrogel materials.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of hydrogels for bio‐printing applications

Murphy

Skardal

Atala

2012

J Biomedical Materials Res

479

367

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In the United States alone, there are approximately 500,000 burn injuries that require medical treatment every year. Limitations of current treatments necessitate the development of new methods that can be applied quicker, result in faster wound regeneration, and yield skin that is cosmetically similar to undamaged skin. The development of new hydrogel biomaterials and bioprinting deposition technologies has provided a platform to address this need. Herein we evaluated characteristics of twelve hydrogels to determine their suitability for bioprinting applications. We chose hydrogels that are either commercially available, or are commonly used for research purposes. We evaluated specific hydrogel properties relevant to bioprinting applications, specifically; gelation time, swelling or contraction, stability, biocompatibility and printability. Further, we described regulatory, commercial and financial aspects of each of the hydrogels. While many of the hydrogels screened may exhibit characteristics suitable for other applications, UV-crosslinked Extracel, a hyaluronic acid-based hydrogel, had many of the desired properties for our bioprinting application. Taken together with commercial availability, shelf life, potential for regulatory approval and ease of use, these materials hold the potential to be further developed into fast and effective wound healing treatments.

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Section: Discussionmentioning

confidence: 99%

Evaluation of hydrogels for bio‐printing applications

Murphy

Skardal

Atala

2012

J Biomedical Materials Res

479

367

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“…It is also poorly immunogenic, it induces hemostasis, it is capable of augmenting tissue thickness and interacts with a variety of cells during wound healing 9,10 . It is also poorly immunogenic, it induces hemostasis, it is capable of augmenting tissue thickness and interacts with a variety of cells during wound healing 9,10 .…”

Section: Introductionmentioning

confidence: 99%

The impact of thickness of resorbable membrane of human origin on the ossification of bone defects: A pathohistologic study

et al. 2012

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“…Nearly all patients with a clinical reaction to bovine collagen express antibovine collagen antibodies 4 . Furthermore, evidence suggests both a B‐ and T‐cell response in the genesis of bovine collagen allergy 5,6 …”

Section: Discussionmentioning

confidence: 99%