The association of congenital heart disease with necrotizing enterocolitis in preterm infants: a birth cohort study

Motta, Cheryl Leah; Scott, William; Mahony, Lynn; Koch, Joshua D.; Wyckoff, Myra H.; Reisch, Joan; Burchfield, Patti J.; Brion, Luc P.

doi:10.1038/jp.2015.96

Cited by 44 publications

(41 citation statements)

References 18 publications

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“…The infants in our study who developed late-onset NEC had been associated with congenital anomalies, and a significant increased risk of mortality. Motta et al [ 20 ] reported similar rates of congenital heart disease and that the infants in their population also had many associated illness and anomalies. [ 21 ] It is possible that more of hypoxic cardiac defects, associated with NEC patients, would place them at a higher risk for intestinal hypoperfusion, which might predispose infants to development NEC and the following complication.…”

Section: Discussionmentioning

confidence: 99%

Postoperative characteristics of infants who developed necrotizing enterocolitis with different postnatal ages

Wang

et al. 2017

Medicine

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Our goal was to investigate the surgical procedures, postoperative complications, and survival with regard to different onset timing of necrotizing enterocolitis (NEC).We performed a retrospective review of medical records with a diagnosis of NEC between 2005 and 2016. The cutoff was set at 10 days for early onset ≤10 days and late onset over 10 days. Propensity score matching was performed to adjust for any baseline differences. In 53 paired patients, clinical outcomes, including, mortality, postoperative complications, and length of neonatal intensive care unit (NICU) stay, were evaluated on the basis of early or late-onset NEC.Successful 1:1 matching propensity score matching was performed with 208 infants. Mortality for early-onset NEC infants was lower than that of early late NEC infants (P = .026). A lower overall postoperative complication rate, including infectious complications [19 (35.8) vs 29 (54.7); odds ratio, 0.462, confidence interval (CI) 0.212–1.008, P = .039], was noted in patients with early-onset NEC compared with infants with late-onset NEC. NICU stay and major complication were marginal different between the 2 groups. Comparison of feeding outcomes revealed that the time to achieve full enteral feeds was significantly longer for those with late-onset NEC (18.1 ± 11.5 vs 26.3 ± 15.6, P = .008).The infants who develop NEC after 10 days of life do influence postoperative outcome survival or other clinically important outcomes after laparotomy.

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Section: Discussionmentioning

confidence: 99%

Postoperative characteristics of infants who developed necrotizing enterocolitis with different postnatal ages

Wang

et al. 2017

Medicine

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“…It is unclear whether microvascular structural changes alone are sufficient to induce NEC, even though congenital heart disease has been recognized as a serious risk factor for NEC (30,31). In this study, VEGFR2 kinase inhibitor administration Fig.…”

Section: Discussionmentioning

confidence: 99%

Lack of VEGFR2 signaling causes maldevelopment of the intestinal microvasculature and facilitates necrotizing enterocolitis in neonatal mice

Yan

Managlia

Liu

et al. 2016

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Some regions had multiple studies other areas had none. A total of eight studies were reported from the United States covering a number of states including: California, Texas, Atlanta, Connecticut, and New York (3,6,9,(27)(28)(29)(30)(31). Multiple studies were also reported from the Europe including Poland, Romania, Finland, Belgium, Sweden and Switzerland (12,13,28,(32)(33)(34).…”

Section: Study Characteristicsmentioning

confidence: 99%

Global Incidence of Necrotizing Enterocolitis: a Systematic Review and Meta-Analysis

Alsaied

Islam

Thalib

2020

Preprint

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Background: Necrotizing Enterocolitis (NEC) is a major cause of morbidity and mortality in the Neonatal Intensive Care Unit (NICU), yet the global incidence of NEC has not been systematically evaluated. We conducted a systematic review and meta-analysis of cohort studies reporting the incidence of NEC in infants with Very Low Birth Weight (VLBW).Methods: The databases searched included PubMed, MEDLINE, the Cochrane Library, EMBASE and grey literature. Eligible studies were cohort or population-based studies of newborns including registry data reporting incidence of NEC. Data were extracted from the selected papers included incidence of NEC cases and size of population at risk, author and publication details, follow up period covered by the study, location and setting of the study and whether it was VLBW infants or preterm infants. Additionally, risk of bias assessment of the included studies were carried out using a validated tool. Bias adjusted Quality Effect Model (QEM) were used to pool the estimates. In the presence of substantial heterogeneity, Random Effect Models (REM) were used as an additionally sensitivity analyses. The heterogeneity between studies were evaluated using the Cochrane Q statistics and Higgin’s I2 value. Subgroup analysis and meta-regression were used to explore the sources of heterogeneity. Funnel plots as appropriate for ratio measures were used to assess publication bias. Results: A systematic and comprehensive search of databases identified 27 cohort studies reporting the incidence of NEC. The pooled estimate of the global incidence of NEC was 6.0% (95% CI: 4.0%-9.0%). There were substantial heterogeneity (I2 = 100%) between studies. Funnel plots showed no evidence of publication bias.Conclusion: Seven out of 100 of all VLBW infants in NICU are likely to develop NEC. However, there were considerable heterogeneity between studies. High quality studies assessing incidence of NEC along with associated risk factors are warranted.

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The association of congenital heart disease with necrotizing enterocolitis in preterm infants: a birth cohort study

Abstract: In this cohort, severe but not mild CHD was independently associated with increased risk for NEC. This finding, if confirmed by other studies, may help identify patients at risk for NEC.

Cited by 44 publications

References 18 publications

Postoperative characteristics of infants who developed necrotizing enterocolitis with different postnatal ages

Postoperative characteristics of infants who developed necrotizing enterocolitis with different postnatal ages

Lack of VEGFR2 signaling causes maldevelopment of the intestinal microvasculature and facilitates necrotizing enterocolitis in neonatal mice

Global Incidence of Necrotizing Enterocolitis: a Systematic Review and Meta-Analysis

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