The association of CD28 polymorphism, rs3116496, with Cancer: A meta-analysis

Baek, Jihae; Lee, Heeyoung; Hwang, Kwang Woo; Kim, Eun Young; Min, Hye‐Young

doi:10.1016/j.compbiomed.2014.11.019

Cited by 6 publications

(3 citation statements)

References 63 publications

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“…Up to now, 3 meta-analyses regarding the impact of rs3116496 on cancer risk have been performed [33,35,36]. Compared with Cong et al (2014), Baek et al (2015) and Zhang et al (2015) studies, our study had the following differences.…”

Section: Discussionmentioning

confidence: 88%

Association Between the CD28 c.17 +3 T>C Polymorphism (rs3116496) and Cancer Risk: An Updated Meta-Analysis

Zeng

Lai

2019

Med Sci Monit

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BackgroundNumerous studies have been conducted on whether CD28 rs3116496 polymorphism affected cancer susceptibility, and these findings have been controversial. Thus, the purpose of this study was to assess the relationship between rs3116496 and susceptibility to cancer.Material/MethodsThe research published as of October 25, 2018 were comprehensively searched in PubMed, Embase, Cochrane Library and Chinese Wanfang database, CNKI, CBM. Statistical calculations performed using Stata12.0.ResultsOverall analyses found that rs3116496 was a risk factor for cancer (C versus T, OR=1.14, 95% CI: 1.01–1.29, PH=0.003), and the heterogeneity was moderate (I2=53.3%). In subgroup analysis results by cancer types, the analysis showed that rs3116496 was a risk factor for breast cancer and leukemia. In the subgroup analysis by ethnicity, rs3116496 was a risk factor for cancer in the Asian population. After PHWE<0.05 was deleted, the analysis showed that rs3116496 might be related to the increased risk of colorectal cancer.ConclusionsOur meta-analysis confirmed that rs3116496 was significantly related to cancer risk, especially in an Asian population, and was strongly correlated with the increased risk of breast cancer, leukemia and colorectal cancer.

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Section: Discussionmentioning

confidence: 88%

Association Between the CD28 c.17 +3 T>C Polymorphism (rs3116496) and Cancer Risk: An Updated Meta-Analysis

Zeng

Lai

2019

Med Sci Monit

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“…Polymorphisms in genes at the molecular level can alter the amino acids encoded by codons and affect gene function, which can lead to the development of cancer [29]. Specifically, a significant association has been demonstrated between the rs3771333 polymorphism in the HJURP gene and susceptibility to hepatitis B virus (HBV)-related HCC [30,31].…”

Section: Hepatocellular Carcinoma (Hcc)mentioning

confidence: 99%

“…HJURP overexpression is generally associated with poor clinical outcomes and promotes tumorigenesis in most cancers, while contrary roles of HJURP have been observed according to database analysis in some cancers and it has been confirmed to act as a cancer suppressor in RCC, albeit with differences among RCC subtypes [60,62]. Likewise, downregulation of HJURP expression caused by HJURP polymorphism may lead to susceptibility to HCC [29]. These findings suggest that HJURP may have a dual role in cancer and more evidence is needed to support this hypothesis.…”

Section: Summary and Perspectivesmentioning

confidence: 99%

Emerging role of HJURP as a therapeutic target in cancers

Tan

Peeraphong²,

Ruchawapol

et al. 2023

Acta Materia Medica

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Holliday junction recognition protein (HJURP) is a key molecular chaperone for centromere protein A (CENP-A), which is essential for chromosome separation during mitosis and cell cycle regulation. Recent studies have identified the essential role of HJURP in carcinogenesis. Abnormal upregulation of HJURP expression has been observed in various human cancers, such as non-small cell lung cancer (NSCLC), hepatocellular carcinoma (HCC), bladder cancer, and breast cancer, and is associated with poor pathologic development and prognosis. In vitro and in vivo studies have shown that HJURP mainly exerts oncogenic functions by regulating the cell cycle, cellular senescence, and epithelial-mesenchymal transition (EMT). The purpose of this review was to evaluate the prognostic significance of HJURP in human cancers and summarize anti-tumor studies targeting HJURP. The factors regulating HJURP in carcinogenesis and the corresponding effects are also discussed to provide new insight into targeting HJURP as a promising strategy for cancer treatment.

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