Role of malonaldehyde as a surrogate biomarker for iron overload in the β-thalassemia patient: A systematic meta-analysis

Basu, Debleena; Adhya, Debashree Guha; Sinha, Rajesh Kumar; Chakravorty, Nishant

doi:10.1016/j.arres.2021.100017

Cited by 4 publications

(2 citation statements)

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“…This was in accordance with Atmakusuma et al [20] who demonstrated that thalassemia patients show increased MDA levels compared to healthy controls reflecting the state of oxidative stress of these patients. In addition, Basu et al [21] reported that Malonaldehyde (MDA) is increased significantly in both transfusion and non-transfusion-dependent βthalassemia. Regardless of severity and blood transfusion dependency they signified MDA as a reliable surrogate indication of iron overload in β-thalassemia.…”

Section: Ragab Et Al [19]mentioning

confidence: 99%

Impact of Haptoglobin Gene Polymorphism on Phenotypic Variability in β-thalassemia Patients: Relation to Iron Overload and Oxidative Stress

Balbaa,

Kamel,

Salem

et al. 2023

Afro-Egyptian Journal of Infectious and Endemic Diseases

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Backgroundand study aim: Thalassemia syndromes are genetic disorders in globin chain production. There is excessive synthesis of reactive oxygen species in thalassemia which leads to oxidative stress. Excessive production of malondialdehyde (MDA) provides evidence that thalassemic erythrocytes contain a significant amount of membrane-bound iron. Inflammatory cytokines trigger the production of haptoglobin (Hp) in the liver. It is characterized by molecular heterogeneity brought on by genetic polymorphism. The aim of the work was to study the impact of haptoglobin gene polymorphism on phenotypic variability in thalassemia patients and its relation to iron overload and oxidative stress. Patients and Methods: This study was carried out on 50 β-thalassemia major patients in addition to 25 healthy age and sex-matched individuals as control. All patients and control were subjected to: history taking, physical examination, Laboratory investigations, Iron profile, Serum ferritin, Serum haptoglobin (Hp), Serum malondialdehyde (MDA), and Haptoglobin gene polymorphism by (PCR). Results:The study revealed significant decrease in serum haptoglobin and significant increase in MDA and ferritin level in thalassemic patients compared to the control group. Higher incidence of Hp2-2 in thalassemic group while control group showed more prevalence of Hp2-1. Serum level of MDA was significantly higher and haptoglobin levels were significantly lower in patients with Hp2-2 genotype. Serum ferritin was higher in the same genotype but did not reach significant value. Conclusion:Haptoglobin polymorphism and phenotypic variability have a major influence on oxidative stress in thalassemia patients.

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Section: Ragab Et Al [19]mentioning

confidence: 99%

Impact of Haptoglobin Gene Polymorphism on Phenotypic Variability in β-thalassemia Patients: Relation to Iron Overload and Oxidative Stress

Balbaa,

Kamel,

Salem

et al. 2023

Afro-Egyptian Journal of Infectious and Endemic Diseases

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“…In addition, the excess iron experienced by patients with beta-thalassemia major is also caused by increased iron absorption in the gastrointestinal tract due to ineffective erythropoiesis. (Basu et al, 2021) . Excess iron accumulation is toxic to tissues and can cause heart failure, cirrhosis, growth disorders, and endocrine disorders (Pietrangelo & Torbenson, 2024).…”

Section: Introductionmentioning

confidence: 99%

Correlation between Adherence Therapy of Iron Chelation Levels with Serum Ferritin Levels in Major Beta-Thalassemia Patients at Kediri District General Hospital

Diyah Permatasari,

Dwi Kartikasari,

Ismail

2023

ihj

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Repeated transfusions, increased absorption of iron, and ineffective erythropoiesis in patients with B thalassemia major cause iron overload, characterized by increased ferritin levels. Iron chelation therapy is needed to overcome iron overload in patients with beta-thalassemia major. The level of adherence affects the success of iron chelation therapy. This study aims to determine the relationship between adherence to iron chelation treatment and serum ferritin levels in patients with thalassemia beta major at Kediri District General Hospital. This type of research is an observational analytic with a cross-sectional design conducted on 17 subjects of B-thalassemia major patients at Pediatric Health Sciences (IKA) RSUD Kediri Regency who met the inclusion and exclusion criteria in December 2022-January 2023. The interviews used the Morisky Medication Adherence Scale questionnaire. -8, while the serum ferritin examination was obtained from the patient's medical record. There were 17 respondents who obeyed 11.76%; the non-compliant category was carried out by Spearman's correlation test and obtained a value of p = 0.01 and a value of r = -0.559. This shows significant results, and there is a moderate correlation between the level of adherence to iron chelation treatment and serum ferritin levels in beta-thalassemia major patients at Kediri District Hospital.

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Identification of severity and passive measurement of oxidative stress biomarkers for β–thalassemia patients: K-means, random forest, XGBoost, decision tree, neural network based novel framework

Basu

Sinha

Sahu

et al. 2022

Advances in Redox Research

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Role of malonaldehyde as a surrogate biomarker for iron overload in the β-thalassemia patient: A systematic meta-analysis

Cited by 4 publications

References 50 publications

Impact of Haptoglobin Gene Polymorphism on Phenotypic Variability in β-thalassemia Patients: Relation to Iron Overload and Oxidative Stress

Impact of Haptoglobin Gene Polymorphism on Phenotypic Variability in β-thalassemia Patients: Relation to Iron Overload and Oxidative Stress

Correlation between Adherence Therapy of Iron Chelation Levels with Serum Ferritin Levels in Major Beta-Thalassemia Patients at Kediri District General Hospital

Identification of severity and passive measurement of oxidative stress biomarkers for β–thalassemia patients: K-means, random forest, XGBoost, decision tree, neural network based novel framework

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