The association of arylendosulfatase 1 (SULF1) gene polymorphism with recurrent miscarriage

Zahraei, Mahnaz; Sheikhha, Mohammad Hasan; Kalantar, Seyed Mehdi; Ghasemi, Nasrin; Jahaninejad, T; Rajabi, Shokohe; Mohammadpour, Hemn

doi:10.1007/s10815-013-0150-7

Cited by 11 publications

(4 citation statements)

References 26 publications

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“…In addition, SULF1 haplotype ACC was associated with an increased risk of PE. A previous study showed that SULF1 rs6990375 polymorphism was related to recurrent miscarriage in Iranian women [42]. Several studies have linked SULF1 genetic polymorphisms to the risk of ovarian cancer [43,44].…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in Sex Hormone Metabolism Genes and Risk of Preeclampsia in Taiyuan, China

Zhang

Yang²,

Feng³

et al. 2017

Gynecol Obstet Invest

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Objective: Aberrant synthesis and metabolism of sex hormone are likely to be associated with alterations in vascular function in preeclampsia (PE). The study aims to investigate whether single nucleotide polymorphisms (SNPs) in sex hormone-related genes are associated with PE. Method: We performed a nested case-control study including 436 pregnant women (203 PE and 233 healthy or normal pregnant women) to investigate associations between 96 SNPs in 28 sex hormone-related genes and risk of PE. Results:TXNRD2/COMT rs3788314 and SULT1A2/SULT1A1 rs4788073 were associated with an increased risk of PE overall (p_trend = 0.004 and 0.003, respectively), early-onset PE (p_trend = 0.007 and 0.009, respectively), and severe PE (p_trend = 0.002 and 0.005, respectively). Additionally, CYP17A1 rs4919690 and rs4919687 and LHCGR rs10180731 were associated with an increased risk of severe PE (p_trend = 0.005, 0.006, and 0.014, respectively), while GNRHR rs2630488 was associated with a decreased risk of severe PE (p_trend = 0.014). We also observed that HSD17B3 rs8190512 was associated with a decreased risk of early-onset PE (p_trend = 0.003). We observed strong linkage disequilibrium in SULF1 (rs10106958, rs7813987, and rs6990375). Conclusions: Our study suggested that genetic polymorphisms in TXNRD2/COMT, SULT1A2/SULT1A1, CYP17A1, HSD17B3, GNRHR, LHCGR, and SULF1 might play a role in PE, especially in early-onset PE and severe PE. Future studies are warranted to replicate the observed associations and their functional mechanisms.

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Section: Discussionmentioning

confidence: 99%

Polymorphisms in Sex Hormone Metabolism Genes and Risk of Preeclampsia in Taiyuan, China

Zhang

Yang²,

Feng³

et al. 2017

Gynecol Obstet Invest

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“…Multiple SULF1 effects arise from the modulation of the BMP, Hedgehog and Wnt signaling pathways, as well as fibroblast growth factors. An association between SULF1 mutation and occurrences of recurrent miscarriage has also been postulated [ 82 ]. Thus, the detected changes in SULF1 expression patterns between physiological and FGR-complicated placentas may play an important role in the determination of this pregnancy pathology.…”

Section: Discussionmentioning

confidence: 99%

Sex-Biased lncRNA Signature in Fetal Growth Restriction (FGR)

Lipka

Jastrzebski

Paukszto

et al. 2021

Cells

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Impaired fetal growth is one of the most important causes of prematurity, stillbirth and infant mortality. The pathogenesis of idiopathic fetal growth restriction (FGR) is poorly understood but is thought to be multifactorial and comprise a range of genetic causes. This research aimed to investigate non-coding RNAs (lncRNAs) in the placentas of male and female fetuses affected by FGR. RNA-Seq data were analyzed to detect lncRNAs, their potential target genes and circular RNAs (circRNAs); a differential analysis was also performed. The multilevel bioinformatic analysis enabled the detection of 23,137 placental lncRNAs and 4263 of them were classified as novel. In FGR-affected female fetuses’ placentas (ff-FGR), among 19 transcriptionally active regions (TARs), five differentially expressed lncRNAs (DELs) and 12 differentially expressed protein-coding genes (DEGs) were identified. Within 232 differentially expressed TARs identified in male fetuses (mf-FGR), 33 encompassed novel and 176 known lncRNAs, and 52 DEGs were upregulated, while 180 revealed decreased expression. In ff-FGR ACTA2-AS1, lncRNA expression was significantly correlated with five DEGs, and in mf-FGR, 25 TARs were associated with DELs correlated with 157 unique DEGs. Backsplicing circRNA processes were detected in the range of H19 lncRNA, in both ff- and mf-FGR placentas. The performed global lncRNAs characteristics in terms of fetal sex showed dysregulation of DELs, DEGs and circRNAs that may affect fetus growth and pregnancy outcomes. In female placentas, DELs and DEGs were associated mainly with the vasculature, while in male placentas, disturbed expression predominantly affected immune processes.

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“…A group has reported a correlation between SULF1 (rs6990375G>A) polymorphism and increased risk of recurrent miscarriage among a subpopulation of Iranian patients in which there were higher frequencies of GG and AA homozygous genotypes among patients. Moreover, higher frequency of AG genotype among healthy cases showed a correlation between this genotype and higher chance of successful pregnancy (Zahraei et al, ). Mitochondria are the cellular bioenergetic centers that have fundamental role during cell proliferation and development through oxidative phosphorylation and ATP production (Dumollard, Duchen, & Carroll, ).…”

Section: Angiogenesismentioning

confidence: 99%

Genetics of recurrent pregnancy loss among Iranian population

Moghbeli

2019

Molec Gen & Gen Med

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Background Recurrent pregnancy loss (RPL) is one of the most common reproductive disorders which is defined as the occurrence of recurrent miscarriage before 24 weeks of gestation and is observed among 1%–5% of women. Methods Various factors are associated with RPL such as immunological disorders, maternal age, obesity, alcohol, chromosomal abnormality, endocrine disorders, and uterine abnormalities. About half of the RPL cases are related with chromosomal abnormalities. Therefore, RPL genetic tests are mainly limited to karyotyping. However, there is a significant proportion of RPL cases without any chromosomal abnormalities that can be related to the single‐gene aberrations. Therefore, it is required to prepare a diagnostic panel of genetic markers besides karyotyping. Results In the present review, we have summarized all the significant reported genes until now which are associated with RPL among Iranian women. We categorized all the reported genes based on their cellular and molecular functions in order to determine the molecular bases of RPL in this population. Conclusion This review paves the way of introducing a population‐based diagnostic panel of genetic markers for the first time among Iranian RPL cases. Moreover, this review clarifies the genetic and molecular bases of RPL in this population.

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The association of arylendosulfatase 1 (SULF1) gene polymorphism with recurrent miscarriage

Cited by 11 publications

References 26 publications

Polymorphisms in Sex Hormone Metabolism Genes and Risk of Preeclampsia in Taiyuan, China

Polymorphisms in Sex Hormone Metabolism Genes and Risk of Preeclampsia in Taiyuan, China

Sex-Biased lncRNA Signature in Fetal Growth Restriction (FGR)

Genetics of recurrent pregnancy loss among Iranian population

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