The Association of Age with Gastric Emptying

Gainsborough, Nicola; Maskrey, Vivienne; Nelson, M. L.; Keating, James W.; Sherwood, Roy; Jackson, S. H. D.; Swift, CG

doi:10.1097/00132586-199310000-00050

Cited by 7 publications

(10 citation statements)

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“…We demonstrated that healthy aging is associated with a modest slowing of gastric emptying of a glucose-containing drink, with increased retention in the proximal stomach. The former observation is consistent with a number of previous studies (10,12) but not all (13,35). The motor mechanisms underlying the observed differences in intragastric distribution are uncertain-aging does not appear to be associated with any change in proximal gastric compliance in the fasted state; there is evidence that gastric accommodation in response to a meal may be delayed (19).…”

Section: Discussionsupporting

confidence: 88%

“…The outcome of studies assessing overall rates of gastric emptying, predominantly using scintigraphy, have been inconsistent (10,(13)(14)(15), perhaps reflecting differences in subject selection criteria (35,37) and the techniques used to quantify gastric emptying (12,35). Moreover, there has hitherto been no information about the effects of aging on intragastric meal distribution and patterns of transpyloric flow.…”

Section: Discussionmentioning

confidence: 99%

“…Studies using scintigraphy and other techniques to evaluate "overall" patterns of gastric emptying have yielded conflicting information about the effects of aging (10)(11)(12)(13), with some consensus that healthy aging is associated with a modest slowing of gastric emptying (10,14,15). The effects of aging on gastric emptying is potentially of relevance to an understanding of oral drug absorption (16,17), appetite regulation (15,18), upper gastrointestinal symptoms (19), and blood glucose homeostasis (20) in this group.…”

mentioning

confidence: 99%

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Effect of Aging on Transpyloric Flow, Gastric Emptying, and Intragastric Distribution In Healthy Humans—Impact on Glycemia

et al. 2005

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The aims of this study were to evaluate (i) the relationship between transpyloric flow (TF) assessed by Doppler ultrasonography and scintigraphy, (ii) the effects of healthy aging on TF and gastric emptying (GE), and (iii) the relationship between the glycemic response to oral glucose and TF. Ten healthy "young" (7 M, 3 F) and 8 "older" (4 M, 4 F), subjects had simultaneous measurements of TF, GE, and blood glucose after a 600-ml drink (75 g glucose labeled with 20 MBq 99mTc-sulfur colloid) while seated. TF measured by ultrasound was measured during drink ingestion and for 30 min thereafter. GE was measured scintigraphically for 180 min after drink ingestion. Blood glucose was measured before the drink and at regular intervals until 180 min. During drink ingestion, TF was greater (P < 0.05) and GE faster (retention at 60 min: 70.8+/-3.3 vs. 83.8+/-4.6%; P < 0.05) in young compared to older subjects. There was no difference in fasting blood glucose between the two groups but the magnitude of the rise in blood glucose was greater in the young compared to the older subjects; (at 15 min 2.4+/-0.3 vs. 1.5+/-0.5 mmol/L; P < 0.05). In contrast, after 90 min blood glucose concentrations were higher in the older subjects. There were significant relationships between the early blood glucose concentration and both TF (e.g., at 15 min: r = 0.56, P < 0.05) and GE (e.g., at 15 min: r = -0.51, P < 0.05). In conclusion, the results of this study indicate that (i) TF is initially less, and GE slower, in older compared to young subjects; (ii) the initial glycemic response to oral glucose is related to TF; and (iii) measurements of TF by ultrasound and scintigraphy correlate significantly.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Effect of Aging on Transpyloric Flow, Gastric Emptying, and Intragastric Distribution In Healthy Humans—Impact on Glycemia

et al. 2005

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“…It is possible that there is a genuine increase in the absorption rate of ibuprofen in the elderly group. However, this seems unlikely in view of the literature on drug absorption and ageing [4, 46], together with the previously reported observations of Greenblatt et al. [31] concerned with ibuprofen.…”

Section: Discussionmentioning

confidence: 95%

Influence of age on the enantiomeric disposition of ibuprofen in healthy volunteers

Tan

Patel

Jackson

et al. 2003

Brit J Clinical Pharma

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Aims To determine the influence of age on the enantioselective disposition of ibuprofen in humans. Methods Healthy young ( n = 16; aged 20-36 years) and elderly ( n = 16; aged 66-84 years) volunteers were given a 400-mg oral dose of racemic ibuprofen, and blood and urine samples were collected for 24 h post drug administration. Serum concentrations, total and free, and urinary excretion of both enantiomers of ibuprofen together with the urinary excretion of the stereoisomers of the two major metabolites of the drug, both free and conjugated, were determined by high-performance liquid chromatography. Results Ageing had little effect on the distribution and metabolism of R-ibuprofen, unbound clearance of the R-enantiomer via inversion being approximately two-fold that via noninversion mechanisms in both age groups. In contrast, the free fraction of S-ibuprofen was significantly greater [33%; young 0.48 ± 0.10%; elderly 0.64 ± 0.20%] mean difference -0.16; 95% confidence interval (CI) -0.05, -0.27; P < 0.01; and the unbound clearance of the drug enantiomer was significantly lower (28%; young 15.9 ± 2.2 l min -1 ; elderly 11.5 ± 4.1 l min -1 ; mean difference 4.4; 95% CI 2.12, 6.68; P < 0.001) in the elderly. The metabolite formation clearances of Sibuprofen via glucuronidation, and oxidation at the 2-and 3-positions of the isobutyl side chain decreased by 24, 28 and 30%, respectively, in the elderly compared with the young, the differences between the two age groups being significant in each case ( P < 0.05). Conclusions Following administration of racemic ibuprofen age-associated stereoselective alterations in drug disposition have been observed, with the elderly having increased free concentrations and lower unbound clearance of the S-enantiomer in comparison with the young. In contrast, the handling of the R-enantiomer is essentially unaltered with age. The results of this study indicate that the elderly have an increased exposure to the active ibuprofen enantiomer and thus some caution may be required when using this drug in this age group.

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“…According to the literature, in healthy populations, there is no correlation between age and gastric emptying. [24][25][26] In this study, we did not examine the rate of Helicobacter pylori infection in DM patients. Some studies have reported changes in gastric emptying after H. pylori eradication, but no defi nite conclusions have been reached.…”

Section: Discussionmentioning

confidence: 99%

Gastric emptying in diabetic patients by the 13C-octanoic acid breath test: role of insulin in gastric motility

et al. 2007

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The Association of Age with Gastric Emptying

Cited by 7 publications

References 0 publications

Effect of Aging on Transpyloric Flow, Gastric Emptying, and Intragastric Distribution In Healthy Humans—Impact on Glycemia

Effect of Aging on Transpyloric Flow, Gastric Emptying, and Intragastric Distribution In Healthy Humans—Impact on Glycemia

Influence of age on the enantiomeric disposition of ibuprofen in healthy volunteers

Gastric emptying in diabetic patients by the 13C-octanoic acid breath test: role of insulin in gastric motility

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