Gastric emptying in diabetic patients by the 13C-octanoic acid breath test: role of insulin in gastric motility

Abstract

IDDM patients showed delayed gastric emptying compared with NIDDM patients, and the (13)C octanoic acid breath test is useful for evaluating DM patients with delayed gastric emptying.

An Update on 13C-Breath Tests: The Transition to Acceptability into Clinical Practice

“…The effects of body positions, 57 gelatinization, 58 various diet ingredients such as aperitif, 59 peppermint oil, 60 coffee, 61 sucralose 62 and in various disease states such as functional dyspepsia, 63,64 celiac disease, 65 cholecystolithiasis, 66 diabetes, 67 obesity, 68 Hirschsprung disease 69 critically ill 70 and GERD 64,71 on the gastric emptying rates have also been researched. Delayed liquid gastric emptying in both children 72 and adults 73 has been studied using 13 C-sodium acetate as a substrate.…”

Diabetic Neuropathy

“…Diabetic autonomic neuropathy affecting the gastrointestinal system may result in gastroparesis, esophageal dysfunction, diarrhea, fecal incontinence, or constipation. Gastroparesis, or delayed gastric emptying, is common in type 1 diabetes, with prevalence rates from approximately 30 to 50% [4,[112][113][114] and appears to be more prevalent in type 1 than in type 2 diabetes [115]. Symptoms of gastroparesis include nausea, vomiting, anorexia, bloating, early satiety, and wide swings in blood sugar [112].…”

Correlation between symptoms of diabetic gastroparesis and results of gastric scintigraphy

“…Alternatives to scintigraphy are: 13C-octanoic acid breath tests (13C-OBT), magnetic resonance imaging (MRI), gastroduodenal manometry, wireless motility capsule ("SmartPill"), autonomic tests, and single photon emission computed tomography [16,17]. Treatment of gastroparesis may involve prokinetic agents, which could accelerate GE and relieve the gastroparetic symptoms [18].…”