The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy

Kolaković, Ana; Živković, Maja; Radak, Djordje; Djurić, Tamara; Končar, Igor; Davidović, Lazar; Dinčić, Dragan; Alavantić, Dragan; Stanković, Aleksandra

doi:10.1177/1470320311423271

Cited by 7 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As different mechanisms might be dominating the different stage of atherosclerosis development, as described previously in this chapter, it is always of importance to perform a genetic association study on early non-stenotic atherosclerosis and advanced stenotic atherosclerosis. A significant independent effect of DD genotype on plaque presence in patients with high-grade carotid stenosis (>70%) was noticed only in normotensive patients [136]. Another study failed to support the hypothesis that ACE genotype is a predictor of either the prevalence or the extent of atherosclerotic plaques but only in young adults [137].…”

Section: Main Ras Molecules In Atherosclerosis Through the Magnifyingmentioning

confidence: 84%

Involvement of the Renin‐Angiotensin System in Atherosclerosis

Kolaković¹,

Živković²,

Stanković³

2017

Renin-Angiotensin System - Past, Present and Future

View full text Add to dashboard Cite

The renin-angiotensin system (RAS) is a well known for its role in the regulation of the blood pressure (BP). Angiotensin II (Ang II), the main mediator of the RAS, may act either, as a systemic molecule or a locally produced factor. Within the vessel wall it has significant proinflammatory role by inducing the oxidative stress, secretion of inflammatory cytokines and adhesion molecules. Ang II could trigger proliferation of vascular smooth muscle cells (VSMC) and its migration to the outer layer of the vessel wall. It could induce the release of matrix metalloproteinase (MMPs), from human VSMC and thus increase susceptibility to rupture of atherosclerotic lesions. Binding of Ang II to AT1R/AT2R could have opposing actions in vascular injury. The ACE2/Ang (1-7)/Mas axis of the RAS also opposes the unfavourable actions of ACE/Ang II/ATR1 axis. Inhibition of RAS could reduce inflammation-associated processes in vasculature, independently of lowering BP. RAS is significantly modulated by the genes coding for this system. Certain genetic variants (SNPs) in the RAS genes have been denoted as the functional ones and have been associated with hypertension, cardiovascular phenotypes and atherosclerosis. Also, the genetic components of the RAS interfere with the regulators of gene expression by microRNAs (miRs).

show abstract

Section: Main Ras Molecules In Atherosclerosis Through the Magnifyingmentioning

confidence: 84%

Involvement of the Renin‐Angiotensin System in Atherosclerosis

Kolaković¹,

Živković²,

Stanković³

2017

Renin-Angiotensin System - Past, Present and Future

View full text Add to dashboard Cite

show abstract

“…U Republici Srbiji je rađeno istraživanje genotipa kod pacijenata sa karotidnom aterosklerozom, a rezultati su pokazali da genotip DD u genu za ACE povezan sa hipertenzijom kod muškaraca < 40 godina, zatim prisustvom aterosklerotskih plakova kod normotenzivnih pacijenata. Alel D je bio češći kod osoba sa simptomatskom karotidnom aterosklerozom u odnosu na asimptomatske [30]. Takođe, studija na hipertenzivnim osobama u Srbiji pokazala je da najveći rizik za nastanak hipertenzije imaju osobe sa kombinacijom genotipa DD u genu za ACE i genotipa 6A6A u genu za metaloproteinazu matriksa -3 [31].…”

Section: Faktori Rizika Za Nastanak Aterosklerozeunclassified

Public health significance of atherosclerosis

Lazić¹,

Mijović²,

Maksimović³

2020

Biomedicinska istraž.

View full text Add to dashboard Cite

Atherosclerosis is the leading cause of cardiovascular disease (CVD) worldwide. Recently, mortality and morbidity from CVD have shown a trend in its occurrence in earlier years, while these diseases have been associated with older age until recently. In developed countries, mortality from diseases caused by atherosclerosis has decreased over the last 50 years. However, such a trend is not reflected in both underdeveloped and developing countries where mortality remains high. Risk factors have been identified and their control can influence the reduction in morbidity and mortality from CVD associated with atherosclerosis. Among these, the so-called variable risk factors are the following: increased concentration of LDL cholesterol fraction (LDL) and/or decreased concentration of HDL cholesterol fraction (HDL), hypertension, cigarette consumption, diabetes mellitus/metabolic syndrome, improper diet, while genetic predisposition is still considered to be an invariable risk factor. In order to reduce the incidence of atherosclerosis, the World Health Organization recommends a two-pronged approach that includes public health interventions to reduce population risk factors and medical interventions for individuals at high risk with stricter surveillance of risk factors. Examples of multisectoral public health interventions include increasing taxes on cigarettes and alcohol, followed by a massive campaign to promote physical activities and healthy diet, that is to promote healthy lifestyles.

show abstract

“…Osobe sa alelom D imaju viši nivo ACE u plazmi, a najviši je kod osoba sa genotipom DD 4 . U Srbiji je genotip DD u genu za ACE asociran sa hipertenzijom kod muškaraca mlađih od 40 godina 5 , zatim sa prisustvom aterosklerotskih plakova kod pacijenata koji nisu imali povišen krvni pritisak, a alel D je bio češći kod simptomatskih pacijenata sa karotidnom aterosklerozom u odnosu na asimptomatske 6 . Ovi podaci, dobijeni u studijama asocijacije u našoj populaciji, govore o predispoziciji osoba sa genotipom DD da razviju pomenute fenotipove.…”

Section: Studije Asocijacije Gena Kandidata Sa Aterosklerozom I Faktounclassified

Basic use of DNA analyses in medicine

Kuveljic¹,

Đurić²,

Jovanović³

et al. 2013

Srce i krvni sudovi

Self Cite

View full text Add to dashboard Cite

Laboratorija za radiobiologiju i molekularnu genetiku, Institut za nuklearne nauke Vinča, Univerzitet u Beogradu, Beograd Pregledni rad Uvod G enetika je do pre dvadeset godina bila nauka koja se trudila da otkrije puteve nasleđivanja osobina i vezu između genotipa i fenotipa, a danas ona zadire u mnoge grane medicine i farmacije i postaje sastavni deo života običnih ljudi, a ne samo znatiželjnih naučnika. DNK analize nisu više samo naučno-istraživačke metode, već imaju bitnu primenu u prevenciji i dijagnostici mnogih bolesti. Na primer, kod naslednih bolesti, u prenatalnoj dijagnostici, u planiranju porodice, koriste se metode molekularne biologije. Postoje različiti tipovi i namene DNK analiza i sve se, naravno, baziraju na osnovama molekularne genetike, čiji kratak pregled sledi. Struktura i organizacija DNK molekulaDeoksiribonukleinska kiselina (DNK) je biomakromolekul koji nosi nasledne informacije i nalazi se u jedru eukariotskih ćelija. Izgrađen je od nukleotida koje čine šećer, azotna baza i fosfatna grupa. Šećer u DNK molekulu je deoksiriboza, pentozni šećer koji gradi fosfodiestarske veze i tako formira kičmu DNK molekula. Azotne baze se kovalentno vezuju za prvi ugljenik u šećeru, čime nastaje nukleozid. Postoje dve klase azotnih baza, purini koji imaju dva povezana heterociklična prstena i pirimidini sa jednim heterocikličnim prstenom. Baze adenin (A) i guanin (G) su purini, a timin (T) i citozin (C) su pirimidini. Kada se na 3' ili 5' ugljenik nukleozida doda fosfatna grupa nastaje nukleotid, osnovna gradivna jedinica DNK molekula. Struktura RNK molekula razlikuje se od strukture DNK molekula po tome što umesto šećera Autor za korespodenciju: Dr Tamara Đurić, Laboratorija za radiobiologiju i molekularnu genetiku, Institut za nuklearne nauke Vinča, Univerzitet u Beogradu, Beograd POBox 522, Tel/fax: 381 11 6447485, Email: tamariska@vinca.rs Genetika je do pre trideset godina bila nauka koja je definisala modele nasleđivanja osobina i vezu između genotipa i fenotipa, a danas ona zadire u mnoge grane medicine i farmacije i postaje sastavni deo naših života. Analize DNK nisu više samo naučno-istraživačke metode, već imaju bitnu primenu u prevenciji i dijagnostici mnogih bolesti. Nauka koja predstavlja sponu između genetike i medicine je genetska epidemiologija koja izučava ulogu genetskih faktora i faktora spoljašnje sredine u etiologiji, progresiji i terapiji bolesti u familijama i populacijama. Genetički markeri mogu biti asocirani sa pretkliničkim, kliničkim i uznapredovalim stadijumom bolesti. Pretklinički genetički markeri mogli bi poslužiti u prevenciji bolesti ili njenom ranom otkrivanju, a klinički i markeri progresije bolesti mogli bi da se iskoriste za pronalaženje i primenjivanje adekvatne terapije.polimorfizam, genetska epidemiologija, ateroskleroza, farmakogenetika SažetakKljučne reči Slika 1. DNK DNK molekul izgrađen je od nukleotida koje čine šećer, azotna baza i fosfatna grupa (P). Prikazane su, prema Watson-Crick-ovom pravilu o komplementarnosti baza, dve vodonične veze između citozina ...

show abstract

The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy

Cited by 7 publications

References 31 publications

Involvement of the Renin‐Angiotensin System in Atherosclerosis

Involvement of the Renin‐Angiotensin System in Atherosclerosis

Public health significance of atherosclerosis

Basic use of DNA analyses in medicine

Contact Info

Product

Resources

About