The association of ABO blood groups with extent of coronary atherosclerosis in Croatian patients suffering from chronic coronary artery disease

Abstract

Aim:The aim of study was to: 1) examine the relationship between ABO blood groups and extent of coronary atherosclerosis in patients with chronic coronary artery disease (CAD), 2) compare ABO blood groups distribution in CAD patients and general population, 3) examine possible differences in traditional risk factors frequency in CAD patients with different ABO blood groups.Materials and methods:In the 646 chronic CAD patients (72.4% males) coronary angiograms were scored by quantitative assessment using multiple angiographic scoring system, Traditional risk factors were self reported or measured by standard methods. ABO blood distribution of patients was compared with group of 651 healthy blood donors (74.6% males).Results:Among all ABO blood group patients there was no significant difference between the extent of coronary atherosclerosis with regard to all the three scoring systems: number of affected coronary arteries (P = 0.857), Gensini score (P = 0.818), and number of segments narrowed > 50% (P = 0.781). There was no significant difference in ABO blood group distribution between CAD patients and healthy blood donors. Among CAD patients, men with blood group AB were significantly younger than their pairs with non-AB blood groups (P = 0.008). Among CAD patients with AB blood group, males < 50 yrs were significantly overrepresented when compared with the non-AB groups (P = 0.003).Conclusions:No association between ABO blood groups and the extent of coronary atherosclerosis in Croatian CAD patients is observed. Observation that AB blood group might possibly identify Croatian males at risk to develop the premature CAD has to be tested in larger cohort of patients.

Biologic roles of the ABH and Lewis histo‐blood group antigens part II: thrombosis, cardiovascular disease and metabolism

“…Conflicting reports do exist, however, with respect to ABO blood group status and its potential association with CAD. An observational study conducted between 2009 and 2010 of 646 Croatian patients with CAD (72·4% male) found no correlation between the number of coronary arteries affected as determined by angiography, or the number of segments narrowed >50%, with ABO blood group , similar to other studies . However, the study did find that blood group AB men developed CAD at a younger age than their non‐AB counterparts .…”

Study frequency of ABO and RH in patients with acute coronary syndrome referred to Ardabil city hospital

“…34,35 In the study of Karabuva et al, 41.33% of patients had the blood group A, 35.29% the blood group O, 16.4% the blood group B and others the AB blood group. 36 In this study, there was no relationship between ACS and blood groups, and there was no significant relationship between the number of vessels involved, the severity of vascular involvement and the type of vessel involvement with the blood groups. In a study, Capuzzo et al stated that patients without blood group O had a significant relationship with the incidence of ACS and led to clinical and subclinical progression of the disease (p=0.02).…”

Non-O blood groups can be a prognostic marker of in-hospital and long-term major adverse cardiovascular events in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention

“…In patients with coronary heart disease, Gong et al found a significant relationship with Gensini [20] and non-O blood groups in Chinese population whereas Karabuva et al observed no association in Croatians [21]. Our study is also the first study investigating this association in STEMI patient population.…”