Non-O blood groups can be a prognostic marker of in-hospital and long-term major adverse cardiovascular events in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention

Çetin, Mehmet Serkan; Çetin, Elif Hande Özcan; Aras, Dursun; Topaloğlu, Serkan; Temizhan, Ahmet; Kisacik, Halil; Aydoğdu, Sinan

doi:10.1016/j.thromres.2015.07.031

Cited by 12 publications

(12 citation statements)

References 27 publications

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“…However, a recent study showed that infarct and the no-reflow were greater for non-O blood groups in patients with ST Segment Elevation Myocardial Infarction (STEMI) [21]. Similarly, according to results of another study, an association between ABO blood groups and spontaneous recanalization was shown in STEMI [22]. Moreover, in previous reports, researchers stated that non-O blood groups had high von Willebrand factor (vWF) levels, which increased vascular thrombosis and increased risk of atherosclerosis [23,24].…”

Section: Discussionmentioning

confidence: 94%

Is There Any Relationship between ABO Blood Groups and Coronary Ectasia?

Kaya¹

2019

Int J Blood Res Disord

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Section: Discussionmentioning

confidence: 94%

Is There Any Relationship between ABO Blood Groups and Coronary Ectasia?

Kaya¹

2019

Int J Blood Res Disord

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“…Subjects of non-O type had higher levels of TC, LDL-C, and NHDL-c [26] . The prevalence of hyperlipidemia, TC, LDL, peak CKMB and no-re ow as well as hospitalization duration were higher in patients with non-O blood groups [27]. Total cholesterol was signi cantly higher in non-O subjects compared to carriers of the O group [30].…”

Section: Gene-based Analysesmentioning

confidence: 87%

“…Besides, some observational studies have found that the blood lipids level was related to ABO blood group. The higher level of TC was found in non-O blood group and was signi cantly associated with an increased prevalence of CVD [25][26][27][28][29][30]. In addition, The GWAS of severe COVID-19 has identi ed the association signal at ABO blood group locus [12].…”

Section: Discussionmentioning

confidence: 99%

“…It should be noticed that ABO was identi ed to be associated with TC signi cantly (p-value = 1.14 × 10 − 15 , FDR = 2.53 × 10 − 13 ). Some observational studies have found that the level of blood lipids was related to ABO blood group and Table 2 lists the detailed information about these observational studies [25][26][27][28][29][30]. All of these studies provide a conclusion that TC is higher in A or non-O blood group, but lower in O blood group.…”

Section: Gene-based Analysesmentioning

confidence: 99%

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Causally Associations of Blood Lipids Levels with COVID-19 Risk: Mendelian Randomization Study

Zhang

Guo

Wang

et al. 2020

Preprint

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BackgroundCoronavirus disease 2019 (COVID-19) is a global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2). It has been found that coronary artery disease (CAD) is a comorbid condition for COVID-19. As the risk factors of CAD, whether blood lipids levels are causally related to increasing susceptibility and severity of COVID-19 is still unknown.ObjectiveWe aim to measure the causal effects between blood lipids and COVID-19 using two-sample Mendelian Randomization (MR) methods.MethodsWe performed two-sample MR analyses to explore whether dyslipidemia, low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol (HDL-c), triglyceride (TG) and total cholesterol (TC) were causally related to COVID-19 risk and severity. The GWAS summary data of blood lipids involving in 312571 individuals and dyslipidemia in a total of 53991 individuals were used as exposures, respectively. Two COVID-19 GWASs including 1221 infected patients and 1610 severe patients defined as respiratory failure were employed as outcomes. ResultsThe MR results showed that dyslipidemia was casually associated with the susceptibility of COVID-19 and induced 27% higher odds for COVID-19 infection (MR-IVW OR = 1.27, 95% CI: 1.08 to 1.49, p-value = 3·18 × 10-3). For blood lipids, the increasing level of TC will raise 18 % higher odds for the susceptibility of COVID-19 (MR-IVW OR = 1.18, 95% CI: 1.06 to 1.31, p-value = 3.08 × 10-3). Based on MR estimates, we further carried out gene-based analysis and found that ABO gene was associated with TC.Conclusions Dyslipidemia is casually associated with the susceptibility of COVID-19 and the blood TC level is a risk factor for the susceptibility of COVID-19. In addition, the different susceptibility of COVID-19 in specific blood group may be partly explained by the TC concentration in diverse ABO blood groups.

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“…Several previous studies have verified the association between blood group A and the increased risk of vascular diseases including coronary artery disease (CAD) [ 10 – 15 ]. Non-O blood groups were also determined to be a significant prognostic indicator of poor prognosis in AMI patients [ 16 – 18 ]. However, there is scarce or even no data about the impact of ABO blood groups on the risk of HR after AMI.…”

Section: Introductionmentioning

confidence: 99%

Blood group A: a risk factor for heart rupture after acute myocardial infarction

Chen

Sun

et al. 2020

BMC Cardiovasc Disord

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Introduction Studies have been performed to identify the association between ABO blood groups and coronary artery disease. However, data is scarce about the impact of ABO blood groups on heart rupture (HR) after acute myocardial infarction (AMI). Methods We conducted a retrospective case–control study that included 61 consecutive patients with HR after AMI during a period from 1 January 2012 to 1 December 2019. The controls included 600 patients who were selected randomly from 8143 AMI patients without HR in a ratio of 1:10. Univariate and multivariate logistic regression analysis were used to identify the association between ABO blood groups and HR. Results Patients with blood group A had a greater risk of HR after AMI than those with non-A blood groups (12.35% vs 7.42%, P < 0.001). After adjusting for age, gender, heart rate at admission, body mass index (BMI), and systolic blood pressure (SBP), blood group A was independently related to the increased risk of HR after AMI (OR = 2.781, 95% CI 1.174–7.198, P = 0.035), and remained as an independent risk factor of HR after AMI in different multivariate regression models. Conclusion Blood group A is significantly associated with increased HR risk after AMI.

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Non-O blood groups can be a prognostic marker of in-hospital and long-term major adverse cardiovascular events in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention

Cited by 12 publications

References 27 publications

Is There Any Relationship between ABO Blood Groups and Coronary Ectasia?

Is There Any Relationship between ABO Blood Groups and Coronary Ectasia?

Causally Associations of Blood Lipids Levels with COVID-19 Risk: Mendelian Randomization Study

Blood group A: a risk factor for heart rupture after acute myocardial infarction

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