The association of –262C/T polymorphism in the catalase gene and delayed graft function of kidney allografts

Dutkiewicz, Grażyna; Domański, Leszek; Bińczak-Kuleta, Agnieszka; Pawlik, Andrzej; Safranow, Krzysztof; Ciechanowicz, Andrzej; Dziedziejko, Violetta; Ciechanowski, Kazimierz

doi:10.1111/j.1440-1797.2009.01270.x

Cited by 5 publications

(3 citation statements)

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“…Catalase is an intracellular antioxidant enzyme effective in protecting cells from hydrogen peroxide [ 41 ]. Catalase is crucial in attenuating graft I/R injuries in the immediate phase after KTx [ 42 , 15 ]. Dutkiewicz et al .…”

Section: Resultsmentioning

confidence: 99%

“…Dutkiewicz et al . [ 15 ] studied the impact of the -262 C/T (rs1001179) polymorphism in CATALASE on renal function outcomes in 187 Polish KTRs. The T allele was associated with a reduced risk of DGF, with increased blood levels of catalase found in the -262 T patients [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

“…I/R-related ROS cause deleterious effects on kidney allografts by triggering inflammatory injuries [ 13 , 14 ]. High-producer polymorphisms in genes coding for antioxidant proteins have been associated with a lower risk of DGF, such as the presence of the -262 T allele in the KTR CATALASE gene [ 15 ] or the presence of the B allele in GSTM1 ( GSTM1*B ) in kidney donors [ 13 ]. In contrast, low-producer polymorphisms have been shown to be deleterious in I/R injury, including rs1695 genotype GG in GSTP1 in KTRs [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

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Genetic susceptibility to delayed graft function following kidney transplantation: a systematic review of the literature

Huart

Krzesinski

Jouret

2018

Clinical Kidney Journal

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Delayed graft function (DGF) is defined as the need for dialysis within 7 days following kidney transplantation (KTx). DGF is associated with increased costs, higher risk for acute rejection and decreased long-term graft function. Renal ischaemia/reperfusion (I/R) injury plays a major role in DGF occurrence. Single nucleotide polymorphisms (SNPs) in certain genes may aggravate kidney susceptibility to I/R injury, thereby worsening post-transplant outcomes. The present article proposes an extensive review of the literature about the putative impact of donor or recipient SNPs on DGF occurrence in kidney transplant recipients (KTRs). Among 30 relevant PubMed reports, 16 articles identified an association between 18 SNPs and DGF. These polymorphisms concern 14 different well-known genes and one not-yet-identified gene located on chromosome 18. They have been categorized into five groups according to the role of the corresponding proteins in I/R cascade: (i) oxidative stress, (ii) telomere shortening, (iii) chemokines, (iv) T-cell homeostasis and (v) metabolism of anti-inflammatory molecules. The remaining 14 studies failed to demonstrate any association between the studied SNPs and the occurrence of DGF. A better understanding of the genetic susceptibility to renal I/R injury may help prevent DGF and improve clinical outcomes in KTRs.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Genetic susceptibility to delayed graft function following kidney transplantation: a systematic review of the literature

Huart

Krzesinski

Jouret

2018

Clinical Kidney Journal

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Genetic Polymorphism of CAT C-262 T and Susceptibility to Breast Cancer, a Case–Control Study and Meta-Analysis of the Literatures

Saadat

2014

Pathol. Oncol. Res.

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Catalase (CAT) activity is likely to be affected by functional polymorphism of C-262 T (rs1001179) in the CAT gene (OMIM: 115500). It is hypothesized that individuals with the lower expressing forms of the CAT polymorphism may be more susceptible to breast cancer. Therefore, the present case-control study and meta-analysis were carried out. The present case-control study consisted of 407 females with breast cancer and a total of 395 healthy female from population matched with patients according to age. Genotypic analysis for the CAT C-262 T polymorphism was determined by PCR. We identified 7 eligible studies, including 10,471 subjects (4,959 patients, and 5,512 healthy controls) in relation to the CAT C-262 T polymorphism and breast cancer risk. Based on the present case-control study, the CT (OR = 0.90, 95% CI: 0.66-1.22, P = 0.484) and TT (OR = 0.68, 95% CI: 0.35-1.30, P = 0.245) genotypes were not associated with breast cancer risk compared to the CC genotype. For meta-analysis including all studies, there was significant heterogeneity between studies. The overall ORs of the breast cancer risk were not associated with the CT (Q-statistic = 14.90, df = 6, P < 0.05; OR = 1.01, 95% CI: 0.92-1.09, P = 0.862) and TT (Q-statistic = 2.57, df = 6, P > 0.05; OR = 1.03, 95% CI: 0.85-1.24, P = 0.770) genotypes. There was no association between C-262 T polymorphism of the CAT and risk of breast cancer.

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Association between genetic polymorphisms and carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma

Yuan

Yip

et al. 2015

Radiat Oncol

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BackgroundRadiotherapy (RT) of the neck is commonly given to nasopharyngeal carcinoma (NPC) patients for preventing cervical lymph node metastasis. However, neck RT may induce the development of carotid atherosclerosis. The mechanisms of radiation-induced carotid atherosclerosis are still unclear and no previous study has investigated the genetic involvement of radiation-induced carotid atherosclerosis. The present study aims to determine the association between genetic polymorphisms and carotid atherosclerosis in patients treated with RT for nasopharyngeal carcinoma.MethodsThe present study recruited 128 post-RT NPC patients. Carotid plaque score was assessed using ultrasonography. Thirteen single nucleotide polymorphisms (SNPs) that affect the function of anti-atherosclerotic genes, including SOD2, SOD3, CAT, PON1, PPARG, ADIPOQ, IL10, TGFB1 and NOS3, were genotyped. Association between the 13 SNPs and carotid atherosclerosis was evaluated using multiple regression after adjustment for covariates (PLINK). Multiple testing was corrected using Benjamini-Hochberg step-up false discovery rate controlling procedure.Resultsrs662 and rs705379 of PON1 were close to be significantly associated with carotid plaque score (Corrected P value, Pcor = 0.0528 and Pcor = 0.0842). When the two SNPs were combined together, TC haplotype in rs662-rs705379 of PON1 was significantly associated with higher carotid plaque score (Pcor < 0.05). None of the other SNPs showed significant association with carotid plaque score.ConclusionsTC haplotype in rs662-rs705379 of PON1 is likely to be a genetic risk factor of carotid plaque score. Post-RT NPC patients with the TC haplotype may need earlier and more frequent carotid ultrasound examinations for early detection of carotid atherosclerosis.

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The association of –262C/T polymorphism in the catalase gene and delayed graft function of kidney allografts

Abstract: The results of this study suggest that -262C/T polymorphism in the catalase gene is associated with DGF in kidney allograft recipients.

Cited by 5 publications

References 27 publications

Genetic susceptibility to delayed graft function following kidney transplantation: a systematic review of the literature

Genetic susceptibility to delayed graft function following kidney transplantation: a systematic review of the literature

Genetic Polymorphism of CAT C-262 T and Susceptibility to Breast Cancer, a Case–Control Study and Meta-Analysis of the Literatures

Association between genetic polymorphisms and carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma

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