Genetic Polymorphism of CAT C-262 T and Susceptibility to Breast Cancer, a Case–Control Study and Meta-Analysis of the Literatures

Abstract

Catalase (CAT) activity is likely to be affected by functional polymorphism of C-262 T (rs1001179) in the CAT gene (OMIM: 115500). It is hypothesized that individuals with the lower expressing forms of the CAT polymorphism may be more susceptible to breast cancer. Therefore, the present case-control study and meta-analysis were carried out. The present case-control study consisted of 407 females with breast cancer and a total of 395 healthy female from population matched with patients according to age. Genotypic analysis for the CAT C-262 T polymorphism was determined by PCR. We identified 7 eligible studies, including 10,471 subjects (4,959 patients, and 5,512 healthy controls) in relation to the CAT C-262 T polymorphism and breast cancer risk. Based on the present case-control study, the CT (OR = 0.90, 95% CI: 0.66-1.22, P = 0.484) and TT (OR = 0.68, 95% CI: 0.35-1.30, P = 0.245) genotypes were not associated with breast cancer risk compared to the CC genotype. For meta-analysis including all studies, there was significant heterogeneity between studies. The overall ORs of the breast cancer risk were not associated with the CT (Q-statistic = 14.90, df = 6, P < 0.05; OR = 1.01, 95% CI: 0.92-1.09, P = 0.862) and TT (Q-statistic = 2.57, df = 6, P > 0.05; OR = 1.03, 95% CI: 0.85-1.24, P = 0.770) genotypes. There was no association between C-262 T polymorphism of the CAT and risk of breast cancer.

Influence of A-21T and C-262T genetic polymorphisms at the promoter region of the catalase (CAT) on gene expression

“…Apart from genetic polymorphisms, a number of environmental factors have significant influence on the CAT activity [4]. It should be noted that in some of these studies, the authors study on breast cancer patients or coal miners [5,23,24]. It is very probable that on the CAT enzyme activity, significant interaction exist between genetic polymorphisms and some of environmental factors.…”

“…Genotyping for the CAT A-21T and C-262T polymorphisms were carried out using PCR based method, as described previously [3,5].…”

“…Three genetic polymorphisms have been reported in the promoter region of the CAT named A-21T (rs7943316), C-262T (rs1001179) and C-844T (rs769214) [2][3][4]. Previous studies have shown that CAT polymorphisms were associated with the risks of several multifactorial diseases [4][5][6][7][8][9][10][11][12][13].…”

Susceptibility to Ulcerative Colitis and Genetic Polymorphisms of A251G SOD1 and C-262T CAT

“…Based on the several studies investigating numerous genetic polymorphisms, it is concluded that the Iranian population is a heterogeneous population (26–28). Also, it has been reported that the allelic frequency of the CAT C-262T and SOD1 A251G polymorphisms is influenced by ethnicity (21, 25, 28, also see: http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=2070424 , and http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=1001179 ). Taken together, our patients and controls were selected among Persian (Caucasian) Muslims living in Shiraz (Fars province, south-west Iran).…”

“…The T allele is associated with lower levels of red blood cell CAT activity (18, 19) which may increase the risk of oxidative stress. Several studies investigated the association between CAT C-262T polymorphism and multifactorial traits (20–25). …”