The association between XPG polymorphisms and cancer susceptibility

Han, Cuihong; Huang, Xuena; Hua, Rui‐Xi; Song, Shujie; Lyu, Lihua; Ta, Na; Zhu, Jinhong; Zhang, Pei-Xi

doi:10.1097/md.0000000000007467

Cited by 15 publications

(13 citation statements)

References 45 publications

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“…XPG rs2296147 was not associated with GC in the present study, a finding consistent with those of other studies[24,25]. However, significant associations between rs2296147 polymorphisms and GC risk were observed in Asian populations in numerous studies in one meta-analysis (CT vs TT: OR = 0.93, 95%CI: 0.87-0.99, P = 0.036)[29]. Further, the rs2296147 CC genotype was associated with a reduced risk of GC in a Chinese population (OR = 0.52, 95%CI: 0.27-0.97)[23].…”

Section: Discussionsupporting

confidence: 92%

Association of XPG rs2094258 polymorphism with gastric cancer prognosis

Wang¹,

Terry²,

Yang³

et al. 2019

WJG

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BACKGROUNDThe xeroderma pigmentosum group G (XPG) gene at chromosome 13q33 consists of 15 exons, which may be related to the occurrence and development of gastric cancer (GC).AIMTo examine the association of several common single nucleotide polymorphisms (SNPs) of the XPG gene with GC risk and survival.METHODSFive SNPs of XPG (rs2094258, rs751402, rs873601, rs2296147, and rs1047768) were genotyped by PCR restriction fragment length polymorphism in 956 histologically confirmed GC cases and 1012 controls in North China. GC patients were followed for survival status and, if deceased, cause of death. Logistic regression and Cox regression were used for analysing associations of XPG SNPs with risk of GC and prognosis, respectively. For rs2094258, heterozygous model (CT vs CC), homozygous model (TT vs CC), recessive model (TT vs CT + CC), and dominant model (TT + CT vs CC) were analyzed.RESULTSNone of the examined loci were statistically associated with GC risk, although rs2296147 was marginally associated with GC risk (P = 0.050). GC patients with the rs2094258 CT + CC genotype showed worse survival than those with the TT genotype (log-rank test, P = 0.028), and patients with the CC genotype had a tendency of unfavourable prognosis compared with those with the TT + CT genotype (log-rank test, P = 0.039). The increase in C alleles of rs2094258 [hazard ratio (HR) = 1.19, 95% confidence interval (CI): 1.02-1.45, P = 0.037] were associated with the long-term survival of GC cases. Other risk factors for survival included tumor differentiation (HR = 4.51, 95%CI: 1.99-8.23, P < 0.001), lymphovascular invasion (HR = 1.97, 95%CI: 1.44-3.01, P < 0.001), and use of chemotherapy (HR = 0.81, 95%CI: 0.63-0.98, P = 0.041).CONCLUSIONThe XPG rs2094258 polymorphism may be associated with overall survival in GC patients.

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Section: Discussionsupporting

confidence: 92%

Association of XPG rs2094258 polymorphism with gastric cancer prognosis

Wang¹,

Terry²,

Yang³

et al. 2019

WJG

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“…XPG expression of rs873601-AA genotype confer to an increase in peripheral blood compared with that of the AG + GG genotypes in the lung cancer group. The rs873601-AA genotype is associated with risk for some cancers, 7,21 the expression of XPG mRNA was decreased in adjacent non-tumor and normal gastric tissues, 22 which in turn indicate rs873601-AA demonstrated the risk factor in lung cancer. Our findings indicated that a genotypedependent change in XPG mRNA may have implications in lung carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

XPG is Modulated by miR-4715-3p and rs873601 Genotypes in Lung Cancer

Yao

Lyu

et al. 2021

CMAR

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Objective: XPG (Xeroderma pigmentosum group G, XPG), a single strand-specific DNA endonuclease in the nucleotide excision repair pathway, has been implicated in lung cancer. Potentially functional rs873601 in XPG is consistently associated with gastrointestinal cancer, and miR-4715-3p, targeting 3UTR of XPG, also influences the process of gastrointestinal carcinogenesis, however, the relationships between XPG and miR-4715-3p and rs873601 in lung cancer have not been elucidated. Methods: A case-control study included 264 lung cancer patients and 264 cancer-free healthy controls and was designed to determine the relationships between rs873601 and lung cancer and the effect of miR-4715-3p on XPG expression in lung cancer. Fifty matched cases and controls were randomly selected from the lung cancer and control groups to assess the relationships between the expression levels of miR-4715-3p and XPG determined by using qRT-PCR. The association of rs873601 with lung cancer was analyzed by mass spectrometry, and function prediciton of rs873601 genotypes explored by web-based bioinformatics. Results: miR-4715-3p in the lung cancer group was significantly increased compared with that in the control group (P = 0.011), upregulation of miR-4715-3p correlated with an increase in XPG mRNA (r = 0.399, P <0.05) in the lung cancer group. The AA genotype was associated with increased risk of lung cancer compared with the AG and GG genotypes of rs873601 (AG vs AA: OR = 0.231, 95% CI: 0.155-0.345, P <0.001 GG vs AA: OR = 0.300, 95% CI: 0.131-0.719, P = 0.003). The genetic association remained significant after adjustment for age, sex, smoking, and drinking, and rs873601-AA was associated with an increase in XPG mRNA in the lung cancer group. The results of web-based bioinformatics analysis indicated rs873601 genotypes might change XPG-RNA stability and bindability between XPG and miR-4715-3p. Conclusion:Our data characterized that miR-4715-3p and rs873601 genotypes modified XPG expression in lung cancer. These findings may help to elucidate the mechanisms governing lung cancer.

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“…Besides, Hua et al [ 24 ] reported that rs873601 A allele can also contribute to the susceptibility of colorectal cancer in a Southern Chinese population with a total of 1,901 cases and 1,976 controls. Two studies have performed comprehensive meta-analyses to evaluate the association of XPG polymorphism rs873601 with cancer risk: Han et al [ 25 ] found that polymorphism rs873601 was significantly associated with overall cancer risk, using data from 12 studies, including 9,158 cases and 10,073 controls focus on rs873601; while another meta-analysis study that included data from 23 reports found that this polymorphism was related to the cancer susceptibility only in Asians [ 26 ]. The ethnic and demographic differences among studies might be partly due to the enormously different frequencies of the rs873601 A allele in different groups (0.48 in Chinese, CHB; 0.53 in Caucasian, CEU; 0.30 in Africans (YRI), according to HAPMAP database, www.hapmap.org/ ).…”

Section: Discussionmentioning

confidence: 99%

XPG rs873601 G>A contributes to uterine leiomyoma susceptibility in a Southern Chinese population

et al. 2018

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XPG gene contributes to DNA repair defects and genomic instability, which may lead to the initiation of uterine leiomyoma. We hypothesized that genetic variants of XPG gene may alter the carriers’ susceptibility to leiomyoma. The association between five potential functional single nucleotide polymorphisms (SNPs), i.e. rs2094258 C>T, rs751402 C>T, rs2296147 T>C, rs1047768 T>C, rs873601 G>A, and uterine leiomyoma risk in Chinese, was investigated in this case–control study, which included 398 incident leiomyoma cases and 733 controls. We found that rs873601 was significantly associated with tumor risk in a recessive genetic model after being adjusting for age and menopause. When compared with rs873601 GG/GA genotypes, the AA genotype had an increased leiomyoma risk (adjusted OR = 1.59, 95% CI = 1.16–2.18, P=0.004; Bonferroni adjusted P=0.040). Furthermore, stratified analysis revealed that the association between the rs873601 AA genotype and leiomyoma risk was more evident among subjects younger than 40 years old (adjusted OR = 1.58, 95% CI = 1.06–2.35, P=0.023) and patients who had more than three myomas (adjusted OR = 2.05, 95% CI = 1.24–3.41, P=0.006). Yet, no significant association between the other four polymorphisms and leiomyoma risk was observed. To sum up, the present study reported on the association between XPG gene polymorphisms and myoma risk. The observed data indicated that SNP rs873601 G>A contributes to uterine leiomyoma susceptibility in a Southern Chinese population.

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The association between XPG polymorphisms and cancer susceptibility

Cited by 15 publications

References 45 publications

Association of XPG rs2094258 polymorphism with gastric cancer prognosis

Association of XPG rs2094258 polymorphism with gastric cancer prognosis

XPG is Modulated by miR-4715-3p and rs873601 Genotypes in Lung Cancer

XPG rs873601 G>A contributes to uterine leiomyoma susceptibility in a Southern Chinese population

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The association between XPG polymorphisms and cancer susceptibility

Cited by 15 publications

References 45 publications

Association of XPG rs2094258 polymorphism with gastric cancer prognosis

Association of XPG rs2094258 polymorphism with gastric cancer prognosis

XPG is Modulated by miR-4715-3p and rs873601 Genotypes in Lung Cancer

XPG rs873601 G&gt;A contributes to uterine leiomyoma susceptibility in a Southern Chinese population

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XPG rs873601 G>A contributes to uterine leiomyoma susceptibility in a Southern Chinese population