XPG rs873601 G>A contributes to uterine leiomyoma susceptibility in a Southern Chinese population

Abstract

XPG gene contributes to DNA repair defects and genomic instability, which may lead to the initiation of uterine leiomyoma. We hypothesized that genetic variants of XPG gene may alter the carriers’ susceptibility to leiomyoma. The association between five potential functional single nucleotide polymorphisms (SNPs), i.e. rs2094258 C>T, rs751402 C>T, rs2296147 T>C, rs1047768 T>C, rs873601 G>A, and uterine leiomyoma risk in Chinese, was investigated in this case–control study, which included 398 incident leiomyoma cases and 733 controls. We found that rs873601 was significantly associated with tumor risk in a recessive genetic model after being adjusting for age and menopause. When compared with rs873601 GG/GA genotypes, the AA genotype had an increased leiomyoma risk (adjusted OR = 1.59, 95% CI = 1.16–2.18, P=0.004; Bonferroni adjusted P=0.040). Furthermore, stratified analysis revealed that the association between the rs873601 AA genotype and leiomyoma risk was more evident among subjects younger than 40 years old (adjusted OR = 1.58, 95% CI = 1.06–2.35, P=0.023) and patients who had more than three myomas (adjusted OR = 2.05, 95% CI = 1.24–3.41, P=0.006). Yet, no significant association between the other four polymorphisms and leiomyoma risk was observed. To sum up, the present study reported on the association between XPG gene polymorphisms and myoma risk. The observed data indicated that SNP rs873601 G>A contributes to uterine leiomyoma susceptibility in a Southern Chinese population.

XPG is Modulated by miR-4715-3p and rs873601 Genotypes in Lung Cancer

“…Previous studies reported that rs873601-AA was associated with some cancers, and XPG rs873601 AA increased the risk of glioma, 24 uterine leiomyoma, 25 and gastric cancer. 26 Our results extend susceptibility of rs873601 to lung cancer, however, rs873601 is not associated with NSCLC that may be due to the fact that most patients enrolled in the study were advanced cases at stage IV (67.4%) and their histological type concentrated on adenocarcinoma (73.2%).…”

TGFβ signaling links early life endocrine-disrupting chemicals exposure to suppression of nucleotide excision repair in rat myometrial stem cells

“…To date, there is limited available information regarding the potential inference of the NER pathway on the physiopathology of UF. A single report done in southern Chinese women has linked a higher susceptibility to UF with a single nucleotide polymorphism in XPG gene (rs873601 G > A), a crucial protein involved in NER repair processes [ 25 ].…”

The Association of ERCC1 and ERCC5 Polymorphisms with Lung Cancer Risk in Han Chinese

“…If DNA repair fails, this damage can lead to carcinogenesis and tumor genomic instability [14]. Genetic and epigenetic aberrations in DNA damage repair pathway genes are associated with various pathogeneses [15][16][17][18][19][20][21][22]. These changes may be useful biomarkers in a liquid biopsy for the early detection and prevention of lung cancer.…”