The association between weight-adjusted-waist index and abdominal aortic calcification in adults aged ≥ 40 years: results from NHANES 2013–2014

Zheng, Qin; Du, Dongru; Li, Yupei; Chang, Kaixi; Yang, Qinbo; Zhang, Zhuyun; Liao, Ri-Qiang; Su, Baihai

doi:10.1038/s41598-022-24756-8

Cited by 17 publications

(11 citation statements)

References 59 publications

(78 reference statements)

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“…WWI was first used to better evaluate the morbidity and mortality of cardiovascular and metabolic diseases in the Korean population (25). Furthermore, trans-ethnic studies have revealed that WWI was positively associated with higher risks of hyperuricemia and multiple kinds of cardiovascular events, including heart failure, abdominal aortic calcification, and left ventricular hypertrophy (14,(26)(27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

Association between weight-adjusted-waist index with hepatic steatosis and liver fibrosis: a nationally representative cross-sectional study from NHANES 2017 to 2020

Shen

et al. 2023

Front. Endocrinol.

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BackgroundThe negative effects of obesity on hepatic steatosis and fibrosis have received considerable attention in recent years. The weight-adjusted-waist index (WWI) reflects weight-independent centripetal obesity. Herein, we provide the first investigation of a link between WWI, hepatic steatosis, and liver fibrosis.MethodsWe used data from the National Health and Nutrition Examination Survey 2017-2020 to conduct a cross-sectional study. The linear relationship between WWI, controlled attenuation parameters, and liver stiffness measurements (LSM) was investigated using multivariate linear regression models. The nonlinear relationship was described using fitted smoothed curves and threshold effect analyses. Subgroup analyses were performed based on gender, age, body mass index, diabetes, hypertension, drinking, and smoking.ResultsThis population-based study included 7,594 people, 50.74% of whom were men and 49.26% of whom were women. Multivariate linear regression analysis revealed a significant positive relationship between WWI and hepatic steatosis [CAP, β=7.60, 95% confidence interval (CI) (4.42, 10.78), P<0.0001]. This positive association was stronger when excessive alcohol intake was present compared to when it was absent (P for interaction = 0.031), and when hypertension was present compared to when it was not (P for interaction = 0.014). The linear relationship between WWI and liver fibrosis was not statistically significant on multiple regression analysis [LSM, β=0.03, 95% CI (-0.26, 0.32), P=0.84]. However, a U-shaped association was seen between WWI and LSM, with a negative correlation when WWI< 10.92 and a positive correlation when WWI > 10.92.ConclusionWe report a strong association between WWI and hepatic steatosis, and suggest that it may potentially be used as a simple anthropometric index to predict hepatic steatosis.

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Section: Discussionmentioning

confidence: 99%

Association between weight-adjusted-waist index with hepatic steatosis and liver fibrosis: a nationally representative cross-sectional study from NHANES 2017 to 2020

Shen

et al. 2023

Front. Endocrinol.

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“…To our knowledge, this is the first longitudinal study examining the relationship between WWI and newly diagnosed T2D. WWI has been explored in a wide range of fields, particularly those related to hypertension, albuminuria, hyperuricemia, left ventricular hypertrophy, and abdominal aortic calcification [ 10 , 11 , 12 ]. The results of these studies reinforce the effectiveness of WWI as a novel indicator of abdominal obesity to predict newly diagnosed T2D in rural China.…”

Section: Discussionmentioning

confidence: 99%

“…Unlike BMI, which cannot distinguish between fat and muscle mass, WWI can better distinguish fat and muscle mass components and mainly reflects the problem of central obesity independent of body weight [ 9 ]. Cumulative evidence confirmed that the increasing value of WWI can be a useful risk factor for hyperuricemia, left ventricular hypertrophy, urinary albumin excretion, and abdominal aortic calcification [ 10 , 11 , 12 , 13 ]. However, the effect of WWI on the incidence of T2D has not been investigated before in rural Chinese patients.…”

Section: Introductionmentioning

confidence: 99%

Weight-Adjusted-Waist Index Predicts Newly Diagnosed Diabetes in Chinese Rural Adults

Wang

Guo

et al. 2023

JCM

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The relationship between the weight-adjusted waist index (WWI) and newly diagnosed type 2 diabetes (T2D) remains uncertain. This study intended to explore the association between the WWI and the incidence of newly diagnosed T2D among participants in rural areas of China. In the Northeast China Rural Cardiovascular Health Study, 9205 non-diabetic individuals (mean age 53 ± 10, 53.1% women) without T2D were included at baseline during 2012–2013. They were followed up from 2015 to 2017. WWI was calculated as waist circumference (cm) divided by the square root of weight (kg). We used multivariate logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the probability of new diagnoses across three WWI categories. A total of 358 participants had been diagnosed with T2D during a median follow-up of 4.6 years. After adjusting for potential confounders, compared with the lowest WWI category (<9.79 cm/√kg in men; <10.06 in women), men with WWI 10.06–10.72 and ≥10.37 cm/√kg showed OR (95%CI) for T2D 1.200 (0.816, 1.767) and 1.604 (1.088, 2.364), respectively, while women with WWI 10.06–10.72 and ≥10.37 cm/√kg showed ORs (95%CIs) for T2D 1.191 (0.703, 2.018) and 1.604 (1.088, 2.364), respectively. The ORs were generally consistent on subgroup analysis by gender, age, body mass index, and current smoking and drinking status. Increasing WWI was significantly associated with a higher incidence of newly diagnosed T2D among rural Chinese adults. Our findings help clarify the harmful effect of increasing WWI on newly diagnosed T2D and provide evidence for formulating healthcare policy in rural China.

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“…Waist circumference (WC) is another anthropometric index that also can be used to examine the risk of female infertility 26,27 . WWI (cm/√kg) was calculated as waist circumference in centimeters divided by the square root of weight in kilograms (WWI = WC/weight^2, WC in centimeters, weight in kilograms) 28,29 …”

Section: Methodsmentioning

confidence: 99%

“…26,27 WWI (cm/√kg) was calculated as waist circumference in centimeters divided by the square root of weight in kilograms (WWI = WC/weight^2, WC in centimeters, weight in kilograms). 28,29…”

Section: Assessment Of Wwimentioning

confidence: 99%

The association between weight‐adjusted‐waist index and self‐reported infertility among women of reproductive age in the United States

He,

Chen,

Bai

2023

J of Obstet and Gynaecol

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AimThis study aimed to determine whether the weight‐adjusted‐waist index (WWI) affected infertility in women of childbearing age in the United States.MethodsIn this study, a database from the 2013 to 2018 National Health and Nutrition Examination Survey (NHANES) was used. We analyzed 3374 participants' data cross‐sectionally. The survey used WWI and fertility status as independent and dependent variables. To determine the effect of WWI, an analysis of the independent relationship between WWI and infertility was conducted using weighted multivariable logistic regression and a generalized additive mode (GAM). A smooth curve fitting test was used to calculate whether there was a linear association between WWI and the incidence rate of infertility, as well as subgroup analyses and interaction tests.ResultsThe prevalence of infertility was 10.19% among 3374 participants. Higher WWI quartiles were associated with higher infertility rates. Based on a fully adjusted model, the effects of WWI on fertility were positive (odds ratio = 1.39, 95% confidence interval: 1.17–1.66). As a result of smooth curve fitting, the association was linear across the entire WWI. Different characteristics were associated with different risks of infertility in subgroup analysis.ConclusionAmong women of reproductive age in the United States, WWI levels were positively associated with infertility. This relationship needs to be confirmed by further studies.

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The association between weight-adjusted-waist index and abdominal aortic calcification in adults aged ≥ 40 years: results from NHANES 2013–2014

Cited by 17 publications

References 59 publications

Association between weight-adjusted-waist index with hepatic steatosis and liver fibrosis: a nationally representative cross-sectional study from NHANES 2017 to 2020

Association between weight-adjusted-waist index with hepatic steatosis and liver fibrosis: a nationally representative cross-sectional study from NHANES 2017 to 2020

Weight-Adjusted-Waist Index Predicts Newly Diagnosed Diabetes in Chinese Rural Adults

The association between weight‐adjusted‐waist index and self‐reported infertility among women of reproductive age in the United States

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