The association between vitamin D and acute rejection in human kidney transplantation: A systematic review and meta-analysis study

Abstract

Background: Vitamin D (VitD) de ciency is associated with several diseases such as multiple sclerosis, rheumatoid arthritis, respiratory infection, and so forth. In the eld of transplantation (kidney transplantation), some studies reported that patients with VitD de ciency are of increased risk of acute rejection, but other studies did not show such a risk. On the other hand, since VitD is a modulatory factor and can reduce the in ammatory response, understanding the exact role of it in transplantation may contribute to tolerance condition in these patients.Methods: The electronic databases, including PubMed, Scopus, Embase, ProQuest, Web of Science, and Google Scholar, were searched for eligible studies. In general, 14 studies with a total of 4,770 patients were included in this meta-analysis. Regarding the methodological heterogeneity, we selected a random-effects combination model. Moreover, OR was chosen as an effect size for this study.Results: After the combination of 14 studies, we showed that patients in the VitD-de cient group had an 82% increased risk of acute rejection compared with patients in the VitD-su cient group, and this effect was signi cant (OR 1.82; 95% con dence interval [CI] [1.29, 2.56]; I 2 = 52.3%). This result was signi cant, and, regarding the narrow CI, it can be a conclusive result. Study quality and gender variables were the main sources of inconsistent results in the primary studies. Moreover, using meta-regression, we showed that VitD de ciency (independent from the estimated glomerular ltration rate (eGFR) of patients) increased the risk of acute rejection. Conclusion:The normal VitD status of patients a few days before and after transplantation can reduce the risk of acute rejection, as it has de nite modulatory effects on immune cells.

Interplay of Vitamin D and SIRT1 in Tissue-Specific Metabolism—Potential Roles in Prevention and Treatment of Non-Communicable Diseases Including Cancer

“…Since vitamin D regulates the immune system, alteration in its level affects the outcome of allografts, e.g., acute cellular rejection (ACR) and infection [ 39 ]. Similarly, several other studies reported that transplanted patients have a higher risk of infections [ 36 , 37 , 167 , 168 , 169 ] and rejections [ 38 , 170 ]. Thus, vitamin D supplementation and tight follow-up of its level is important in transplant recipient patients [ 39 ].…”

“…Many of these are associated with a reduced level of SIRT1 as well [ 34 , 35 ]. Vitamin D levels may influence the risk of infections in kidney and liver transplant recipients [ 36 , 37 ] and the risk of acute rejection [ 38 , 39 ] and of new-onset diabetes after kidney transplantation [ 40 ].…”

The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review

“…Additionally, studies that investigated the role of vitamin D supplementation therapy were excluded from this meta-analysis. Another recent meta-analysis of 14 studies by Mirzakhani et al focused only on the role of vitamin D on acute rejection following KT and revealed an 82% higher chance of acute rejection in patients suffering from vitamin D deficiency [ 33 ].…”

Incident Of Vitamin D Deficiency In Derna City\libya

“…Vitamin D lack is related with a few illnesses like various sclerosis, rheumatoid joint pain, respiratory contamination, etc. In the Field of transplantation (kidney transplantation) [22]. Vitamin D inadequacy has been related with respiratory pain disorder, pneumonic fibrosis expanded degrees of IL-2, and cardiovascular antagonistic events [23].…”