The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review

Koimtzis, Georgios; Stefanopoulos, Leandros; Brooker, Verity; Geropoulos, Georgios; Chalklin, Christopher; Gupta, Sapna; Carrington-Windo, Eliot; Papaioannou, Maria; Papavramidis, Theodosios

doi:10.3390/life12101664

Cited by 3 publications

(6 citation statements)

References 41 publications

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“…This study is the first, to our knowledge, to show an association between the 25(OH)D status post‐KT and dn DSAs occurrence 32 . Moreover, this study presents an original longitudinal assessment of 25(OH)D levels up to 3 years post‐transplant.…”

Section: Discussionmentioning

confidence: 86%

“…One strength of this study is the yearly longitudinal measurement of 25(OH)D levels for 36 months for a high number of KTRs 32 . Indeed, previous studies merely provided a single 25(OH)D measurement after KT 7–10,12 .…”

Section: Discussionmentioning

confidence: 99%

“…One strength of this study is the yearly longitudinal measurement of 25(OH)D levels for 36 months for a high number of KTRs. 32 Indeed, previous studies merely provided a single 25(OH)D measurement after KT. [7][8][9][10]12 Longitudinal measurements of 25(OH)D showed that the rate of KTRs with inadequate 25(OH)D levels peaked at M12 post-KT and then decreased at M24 and M36, which has never been described while of great importance.…”

Section: Discussionmentioning

confidence: 99%

“…This study is the first, to our knowledge, to show an association between the 25(OH)D status post-KT and dnDSAs occurrence. 32 Moreover, this study presents an original longitudinal assessment of 25(OH)D levels up to 3 years post-transplant. This allowed to evidence associations between 25(OH)D levels and different KT outcomes at different time points in the same cohort.…”

Section: Discussionmentioning

confidence: 99%

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25‐hydroxyvitamin D sufficiency is associated with lower de novo anti‐HLA donor specific antibody and better kidney transplant outcomes

Bakis,

Bouthemy,

Corcuff

et al. 2023

HLA

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T‐cell mediated rejection (TCMR), de novo anti‐HLA donor‐specific antibodies (dnDSAs) and ensuing antibody‐mediated rejection (ABMR) reduce kidney transplantation (KT) survival. The immunomodulatory effects of 25‐hydroxyvitamin D [25(OH)D] could be beneficial for KT outcomes. We aimed to evaluating the association between 25(OH)D levels, the development of dnDSAs, clinical TCMR and ABMR, and graft survival. This single center retrospective study included 253 KT recipients (KTRs) transplanted without preformed DSA between 2010 and 2013. We measured 25(OH)D in successive serum samples: at KT (M0) and M12 for the entire cohort, and additionally at M24 and/or M36 when sera were available. We assessed graft outcomes up to 5 years post‐KT. The proportion of KTRs having sufficient 25(OH)D at KT (M0) was high (81.4%) and then dropped at M12 (71.1%). KTRs with sufficient 25(OH)D at M0 experienced less clinical TCMR (HR, 0.41; 95% CI, 0.19–0.88 in multivariate analysis). A sufficient 25(OH)D at M12 was independently associated with a longer dnDSA‐free survival (HR, 0.34; 95% CI, 0.17–0.69). There was no association between 25(OH)D and clinical AMBR. Studying the KTRs with 25(OH)D measurements at M12, M24 and M36 (n = 203), we showed that 25(OH)D sufficiency over the 3 first‐years post‐KT was associated with a longer graft survival in multivariate analyses (HR, 0.39; 95% CI, 0.22–0.70). To our knowledge, this study is the first showing an association between 25(OH)D sufficiency post‐KT and dnDSA occurrence in KTRs. Moreover, we reinforce previously published data showing an association between 25(OH)D, TCMR and graft survival in KT.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

25‐hydroxyvitamin D sufficiency is associated with lower de novo anti‐HLA donor specific antibody and better kidney transplant outcomes

Bakis,

Bouthemy,

Corcuff

et al. 2023

HLA

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“…Most of the studies showed a negative effect of vitamin D deficiency on kidney transplantation by being associated with a worse graft function, higher incidence of acute rejection episodes, higher incidence of proteinuria and lower overall graft and patient survival rate ( 1 ).It is well-established that Vitamin D (VD) plays a crucial role in mineral and bone metabolism as well as the treatment of secondary hyperparathyroidism in patients with chronic kidney diseases (CKD). Recently, there has been an increasing focus on the immunomodulatory effects of VD in KTRs.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D supplementation reduced blood inflammatory cytokines expression and improved graft function in kidney transplant recipients

Bai

et al. 2023

Front. Immunol.

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BackgroundChronic allograft dysfunction(CAD) is the leading cause of graft loss in kidney transplant recipients (KTRs). Inflammatory process is believed to be one of the major contributors to CAD. The aim of this study is to explore the anti-inflammatory effect of vitamin D (VD) supplementation in KTRs and its role in the graft function improvement(protection).MethodsA retrospective cohort of 39 KTRs with chronic antibody mediated rejection(CAMR)or stable renal function and a prospective cohort of 42 KTRs treated or untreated with VD were enrolled. Serum levels of vitamin D metabolism and serum inflammatory cytokines, renal graft function, and routine blood biomarkers were tested and dynamically tracked within 12 months post-transplant.ResultsCompared with the stable group, the CAMR group exhibited significantly elevated serum levels of inflammatory cytokines IL-1β, IFN-γ, IL-2, IL-10, IP-10, and HMGB1 (P <0.05). The supplementation of vitamin D effectively increased the serum concentration of vitamin D in kidney transplant recipients (KTRs) in the treated group. During the course of treatment, the treated group exhibited a gradual increase in eGFR levels, which were significantly higher than those observed in the untreated group at 12 months post-transplant (p<0.05). Notably, as eGFR improved, there was a significant decrease in levels of IL-1β, IFN-γ, IL-2, IL-10, IP-10 and HMGB1 in the treated group compared to the untreated group (P<0.05).ConclusionThis study confirmed that immune-inflammation is a crucial factor in the development of CAD in KTRs.VD deficiency impairs its anti-inflammatory activity. By assisting in the regulation of excessive immune inflammation and restoration of immune homeostasis, effective VD supplementation contributes to protection and maintenance of graft function in KTRs.

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Difficulties and Needs of Organ Transplantation Patients After Discharge

BAYSOY

2023

Journal of Innovative Healthcare Practices

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Organ nakli, cerrahideki ilerlemeler ve immünosüpresif ilaçların gelişmesiyle beraber işlev ve fonksiyonunu yitiren organlar için en etkili tedavi yöntemidir. Ancak organ nakil hastaları ameliyat sonrası evde psikolojik, fizyolojik ve sosyal bazı zorluklar yaşamaktadırlar. Nakilden sonra hastalar yaşamlarının büyük çoğunluğunu evde geçirmektedir. Nakil sonrası hastalar başta psikolojik zorluklar olmak üzere fizyolojik, sosyal ve diğer zorluklar yaşamaktadırlar. Hastaların bu zorluklarla başa çıkması için bazı gereksinimleri oluşmaktadır. Hastalar en fazla psikolojik alanda bir ihtiyaç duymakla beraber eğitim ve bilgi ihtiyacı, sosyal ve diğer ihtiyaçların karşılanma hissi duymaktadırlar. Ayrıca organ nakli hastalarının yaş gruplarına ve cinsiyetlerine göre karşılaşılan zorluklar ve gereksinimleri değişebilmektedir. Bu nedenle organ nakli olan hastaların evde bakımlarının düzenli yapılması ve sosyal desteğin sürdürülmesi hastanın yaşam kalitesini yükseltmesi açısından önemlidir. Hastalara organ nakli sonrası sunulan taburculuk eğitiminin ve sağlanan bilgilerin yeterli ve açık olmadığı görülmektedir. Sağlık profesyonelleri organ nakli sonrası hastaların karşılaşacakları zorluklar ve gereksinimleri önceden belirleyerek hastaya özgü eğitim vermelidir. Ameliyat sonrası hasta ve hasta yakınları ile etkili iletişimin sağlanması, hastaların bu süreci daha kolay atlatması ve yaşam kalitesini yükseltmesi açısından oldukça önemlidir.

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The Role of Vitamin D in Kidney Transplantation Outcomes: A Systematic Review

Cited by 3 publications

References 41 publications

25‐hydroxyvitamin D sufficiency is associated with lower de novo anti‐HLA donor specific antibody and better kidney transplant outcomes

25‐hydroxyvitamin D sufficiency is associated with lower de novo anti‐HLA donor specific antibody and better kidney transplant outcomes

Vitamin D supplementation reduced blood inflammatory cytokines expression and improved graft function in kidney transplant recipients

Difficulties and Needs of Organ Transplantation Patients After Discharge

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