The association between vitamin D receptor FokI gene polymorphism and osteoporosis in postmenopausal women: a meta-analysis

Wang, S; Ai, Zhipeng; Song, Meijuan; Yan, Pu; Li, J

doi:10.1080/13697137.2020.1775806

Cited by 15 publications

(15 citation statements)

References 38 publications

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“…AuthorYear Age MPO rs2234693/(rs9340799) Control rs2234693/(rs9340799) Method MPO controlTT/(AA)TC/(AG) CC/(GG) T/(A) C/(G) TT/(AA)TC/(AG) CC/(GG) T/(A) C/(G) Wang et al [30] 2017 62.…”

Section: Meta-analysis Resultsmentioning

confidence: 99%

Association of ESR1 polymorphism rs2234693 and rs9340799 with Postmenopausal osteoporosis in a Chinese Population

Shu

et al. 2020

Preprint

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Background Postmenopausal osteoporosis (PMO) is the most common type of primary osteoporosis. ESR1 polymorphism rs2234693 and rs9340799 has been widely studied as a candidate gene associated with PMO, however, the findings were inconclusive. The present study aims to explore the relationship of ESR1 polymorphism rs2234693 and rs9340799 with PMO risk in a Chinese Han population. Methods A total of 230 unrelated PMO patients and 150 control were recruited. DNA of all participants was extracted from the peripheral blood samples and genotyped by Mass Array method. A meta-analysis of case control studies was also conducted to further elucidate the relationship of polymorphism with PMO. Results Our results revealed that there were no associations of the rs2234693 with PMO. However,GG genotype of rs9340799 was associated with a higher risk of PMO (OR=1.51, 95%CI:1.08-4.34, p=0.03), even adjusting for risk factors (OR=1.83, 95%CI: 1.12-5.04, p=0.04). Logistic regression analysis showed the dominant model was associated with a higher risk of PMO (OR = 2.07, 95%CI: 1.02-5.16, p=0.02) after correcting the risk factors (OR=2.14, 95%CI:1.12-5.64, p=0.04); In addition, the Meta-analysis results revealed that both two polymorphisms were not associated with PMO. Conclusion In conclusion,ESR1 polymorphism rs9340799 was associated with PMO, However, well designed study with larger sample sizes, is required to further elucidate these association.

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“…AuthorYear Age MPO rs2234693/(rs9340799) Control rs2234693/(rs9340799) Method MPO controlTT/(AA)TC/(AG) CC/(GG) T/(A) C/(G) TT/(AA)TC/(AG) CC/(GG) T/(A) C/(G) Wang et al [30] 2017 62.…”

Section: Meta-analysis Resultsmentioning

confidence: 99%

Association of ESR1 polymorphism rs2234693 and rs9340799 with Postmenopausal osteoporosis in a Chinese Population

Shu

et al. 2020

Preprint

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“…This meta-analysis only discussed genetic factors in the original literature, and the interaction of other factors such as dietary calcium and light exposure and VDR gene polymorphisms on osteoporosis was uninvolved. Therefore, referring to the analysis methods of other researchers [64], we focused on checking the details of the dietary habits of the participants in each study and determined that there was no difference in calcium intake between the case-control group. We believe that for more accurate evaluation of the relationship between vitamin D receptor gene polymorphism and postmenopausal osteoporosis, researches having large samples are required, and the synergy of other factors such as diet, environment, and exercise should be considered more comprehensively when cases are included in the group.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies

et al. 2020

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Objective This study aimed to quantitatively summarize the evidence for VDR BsmI gene polymorphism and osteoporosis risk in postmenopausal women. Materials and methods The PubMed, EMBASE, Weipu, CNKI, and Wanfang databases were searched for eligible studies. Case-control studies containing available genotype frequencies of B/b were chosen, and odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. Results 4485 osteoporosis and 5490 controls were identified in our meta-analysis. In the stratified analysis, a significant association was observed between VDR BsmI gene polymorphism and osteoporosis susceptibility in Caucasians (additive model: OR = 0.809, 95% CI 0.678~0.965, p = 0.019; recessive model: OR = 0.736, 95% CI 0.568~0.955, p = 0.021; and co-dominant model: bb vs. BB OR = 0.701, 95% CI 0.511~0.962 p = 0.028), and we failed to find any significant relationship in Asians. Conclusion The present meta-analysis suggests that VDR BsmI genotype is associated with increased risk of postmenopausal osteoporosis in Caucasians but not in Asians. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VDR BsmI polymorphism and osteoporosis in postmenopausal women.

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“…This meta-analysis only discussed genetic factors in the original literature, and the interaction of other factors such as dietary calcium and light exposure and VDR gene polymorphisms on osteoporosis was involved. Therefore, referring to the analysis methods of other researchers 59 , we focused on checking the details of the dietary habits of the participants in each study, and determined that there was no difference in calcium intake between the case-control group. We believe that for more accurate evaluation of the relationship between vitamin D receptor gene polymorphism and postmenopausal osteoporosis, researches having large samples are required, and the synergy of other factors such as diet, environment, exercise, etc.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Receptor Bsm I Polymorphism and Osteoporosis Risk in postmenopausal women: A Meta-Analysis from 42 Studies

Liao

Qin

Zhou

et al. 2020

Preprint

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Objective: This study aimed to quantitatively summarize the evidence for VDR BsmI gene polymorphism and osteoporosis risk in postmenopausal women. Materials and Methods: The PubMed, EMBASE, Weipu, CNKI, and Wanfang database were searched for eligible studies. Case-control studies containing available genotype frequencies of B/b were chosen, and Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. Results: 4485 osteoporosis and 5490 controls were identified in our meta-analysis. In the stratified analysis, a significant association was observed between VDR BsmI gene polymorphism and osteoporosis susceptibility in Caucasians (additive model: OR=0.809, 95% CI 0.678~0.965, p=0.019, recessive model: OR=0.736, 95% CI 0.568~0.955, p=0.021, and co-dominant model: bb vs. BB OR=0.701, 95% CI 0.511~0.962 p= 0.028), and we failed to find any significant relationship in Asians. Conclusion: The present meta-analysis suggests that VDR BsmI genotype is associated with increased risk of osteoporosis in Caucasians but not in Asians. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VDR BsmI polymorphism and osteoporosis.

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The association between vitamin D receptor FokI gene polymorphism and osteoporosis in postmenopausal women: a meta-analysis

Cited by 15 publications

References 38 publications

Association of ESR1 polymorphism rs2234693 and rs9340799 with Postmenopausal osteoporosis in a Chinese Population

Association of ESR1 polymorphism rs2234693 and rs9340799 with Postmenopausal osteoporosis in a Chinese Population

Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies

Vitamin D Receptor Bsm I Polymorphism and Osteoporosis Risk in postmenopausal women: A Meta-Analysis from 42 Studies

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