The association between vitamin D level and periodontal disease in Saudi population, a preliminary study

Madi, Marwa; Pavlić, Verica; Alammar, Shahad Mongith; Alsulaimi, Leenah; Alotaibi, Reema; Alotaibi, Gadah; Zakaria, Osama

doi:10.1016/j.sdentj.2020.08.002

Cited by 8 publications

(7 citation statements)

References 42 publications

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“…25(OH) D was the most commonly form used to assess Vit. D level, due its long life in body fluids reaching 20 days, on the other side 1,25(OH) D occurs only for up to 4 hours (Madi et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…D serum levels in individuals suffering from periodontitis alone or in conjunction with ischemic heart disease when compared to individuals suffering from only ischemic heart disease or healthy controls. Moreover, Madi et al, (2020) stated that serum Vit. D level had been considered a crucial factor which might reflect and influence the periodontal condition.…”

Section: Discussionmentioning

confidence: 99%

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Estimation of Vitamin D Gingival Crevicular Fluid Level In Patients With Different Periodontal Conditions.

Barbary

Hegab

2022

Egyptian Dental Journal

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Background: Vitamin D (Vit. D) is responsible in the process of calcium homeostasis, among many other biological effects. Thus it plays an essential role in bone related diseases. Furthermore, several studies investigated the link between Vit. D plasma level and various conditions of periodontal diseases.Objective: Therefore, the present study aimed to assess Vit. D3 [25(OH) D] gingival crevicular fluid (GCF) levels in individuals with different periodontal conditions.Subjects and methods: 60 GCF samples were taken from 60 individuals divided into 3 equal groups, healthy, gingivitis and periodontitis. Vit. D GCF level was assessed using ELISA technique.Results: There was a statistically significant difference between (gingivitis, periodontitis and healthy control) groups, with mean and SD [4.4 + 0.3 ng/ml, 3.5 + 0.4 ng/ml, 5.6 + 0.5 ng/ml] respectively (P value 0.001). Conclusion:The results are supporting the link between 25(OH) D GCF level and the periodontal condition. The study might be emphasizing the correlation between the periodontal disease and deficiency in Vit. D.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Estimation of Vitamin D Gingival Crevicular Fluid Level In Patients With Different Periodontal Conditions.

Barbary

Hegab

2022

Egyptian Dental Journal

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“…The results of current trial reported that the serum levels of vitamin D3 were statistically significantly lower among the patients with periodontitis in comparison with the healthy individuals (31.34 nmol/L; SD = 5.62 vs. 39.64 nmol/L; SD = 8.77) regardless age and gender. The association between serum levels of vitamin D3 and periodontal status has been investigated in many studies and lower levels of vitamin D3 are reported to be associated with periodontitis [ 22 , 23 , 24 ]. In a cross-sectional investigation by Bonnet et al [ 23 ], vitamin D status was determined by 25(OH)D concentrations and a statistically significant association was observed between CAL and 25(OH)D levels lower than 75 nmol/L; however, the authors did not find such correlation with vitamin D levels lower than 50 nmol/L.…”

Section: Discussionmentioning

confidence: 99%

“…In a cross-sectional investigation by Bonnet et al [ 23 ], vitamin D status was determined by 25(OH)D concentrations and a statistically significant association was observed between CAL and 25(OH)D levels lower than 75 nmol/L; however, the authors did not find such correlation with vitamin D levels lower than 50 nmol/L. The study by Madi et al [ 24 ] aimed to assess the relationship between vitamin D levels and periodontal health among individuals in the Eastern Province of Saudi Arabia. A total of 67 participants were categorized according to vitamin D level (<10, <20 and >20 ng/mL) and their bone loss was compared.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D3 Serum Levels in Periodontitis Patients: A Case–Control Study

Olszewska-Czyż

Firkova

2022

Medicina

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Background: Periodontitis is a multifactorial disease characterized by bacterial-dysbiosis-associated, host-mediated inflammation, which results in the loss of the tooth-supporting tissues. Vitamin D3 plays an important role in the tissue homeostasis and its deficiency might have a negative effect on the periodontitis progression and treatment outcomes. Objectives: The aim of the study was to evaluate the vitamin D3 serum levels among patients with periodontitis and healthy subjects. Materials and Methods: A total of 100 generally healthy adult participants (50 diagnosed with periodontitis, 50 with healthy periodontium) were enrolled in the study. The periodontal clinical parameters were measured, radiographs were performed and the 25-hydroxy vitamin D (25(OH)D) test was used to assess vitamin D3 levels. Results: Vitamin D3 levels were found to be statistically significantly lower among periodontitis patients (31.34; SD = 5.62) compared with healthy controls (39.64; SD = 8.77). Vitamin D3 deficiency was corresponding to the stage and grade of the disease as well as the clinical attachment and bone loss. Conclusion: Adequate monitoring of the vitamin D3 serum levels and supplementation could be of benefit in periodontitis treatment.

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“…Despite these plausible mechanisms linking Vitamin D to dental health, the evidence remains inconclusive and is characterized by considerable heterogeneity. Some studies have indicated a strong association between Vitamin D and dental health [ 11 , 12 ], while others have reported no significant association [ 13 ]. This inconsistency in the literature underscores the need for a more systematic investigation of the role of Vitamin D in enamel defects and tooth erosion.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Prenatal Vitamin D on Enamel Defects and Tooth Erosion: A Systematic Review

Tapalaga,

Bumbu,

Reddy

et al. 2023

Nutrients

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Prenatal Vitamin D has been suggested to be critical for dental health in children, affecting outcomes including the prevalence of enamel defects and tooth erosion. This systematic review aimed to evaluate the potential impact of prenatal Vitamin D levels on these dental health outcomes. A total of seven studies, involving 6978 participants, were included after a comprehensive search of PubMed, Web of Science, and Scopus from 2013 to June 2023. The average age of mothers varied across studies, with Vitamin D levels or supplementation practices displaying significant variation among the study populations. The age of children at examination ranged from 3.6 to 6.6 years. The analysis demonstrated a diverse association between Vitamin D levels and dental outcomes, with enamel defects reported in 21.1% to 64% of the children and opacities ranging from 36% to 79.5% across studies. Maternal Vitamin D insufficiency was identified as a significant risk factor for enamel defects in one study (OR: 3.55), whereas high prenatal Vitamin D levels indicated a protective effect against Hypomineralized Second Primary Molars (OR: 0.84) and Molar Incisor Hypomineralization (OR: 0.95) in another. Conversely, low Vitamin D levels increased the risk of enamel hypoplasia (OR: 1.29) and dental decay. The maternal and child demographics varied greatly across the studies, and the assessment and prevalence of Vitamin D deficiency or insufficiency were heterogenous. This review illuminates the potential influence of prenatal Vitamin D on dental health in children, underscoring the importance of adequate Vitamin D levels during pregnancy. However, more robust research is required to establish the optimal Vitamin D intake during pregnancy to ensure healthy dental outcomes in children.

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The association between vitamin D level and periodontal disease in Saudi population, a preliminary study

Cited by 8 publications

References 42 publications

Estimation of Vitamin D Gingival Crevicular Fluid Level In Patients With Different Periodontal Conditions.

Estimation of Vitamin D Gingival Crevicular Fluid Level In Patients With Different Periodontal Conditions.

Vitamin D3 Serum Levels in Periodontitis Patients: A Case–Control Study

The Impact of Prenatal Vitamin D on Enamel Defects and Tooth Erosion: A Systematic Review

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