G-MSCs in conjunction with IL-1ra-loaded/unloaded HA-sECM show a significant periodontal regenerative potential.

Background: Gingival recession (GR) is a challenging condition especially with the increasing esthetic demand of patients today. Hence, there is a need to assess the prevalence of GR and to investigate possible associations with this condition. Methods: A cross-sectional observational study design was used where a sample of 500 patients, within the age range of 18-60 years, was drawn from the Faculty of Oral and Dental Medicine at Cairo University. The collected data included demographic and periodontal variables, and the significance level was set at P ≤ 0.05. Statistical analysis was performed via IBM® SPSS® Statistics Version 20 for Windows using the Chi-square and Fisher exact test. Results: The overall prevalence of GR was 69.4%. Statistical analysis indicated a significant association between gender and GR (significant male predilection, P ≤ 0.05), and between GR and plaque biofilm due to periodontitis with 90.8% of recession cases having periodontitis. A significant association was also found between the cause and distribution of GR, where mandibular incisors showed the highest prevalence of GR. Conclusion: Gingival recession is a highly prevalent condition among Egyptians, with periodontitis being the fundamental cause. Frenal pull is the most prominent local factor in inducing GR in the Egyptian population. This information can be applied by educating the population and initiating new preventive programs and awareness campaigns.

Background: Vitamin D (Vit. D) is responsible in the process of calcium homeostasis, among many other biological effects. Thus it plays an essential role in bone related diseases. Furthermore, several studies investigated the link between Vit. D plasma level and various conditions of periodontal diseases.Objective: Therefore, the present study aimed to assess Vit. D3 [25(OH) D] gingival crevicular fluid (GCF) levels in individuals with different periodontal conditions.Subjects and methods: 60 GCF samples were taken from 60 individuals divided into 3 equal groups, healthy, gingivitis and periodontitis. Vit. D GCF level was assessed using ELISA technique.Results: There was a statistically significant difference between (gingivitis, periodontitis and healthy control) groups, with mean and SD [4.4 + 0.3 ng/ml, 3.5 + 0.4 ng/ml, 5.6 + 0.5 ng/ml] respectively (P value 0.001). Conclusion:The results are supporting the link between 25(OH) D GCF level and the periodontal condition. The study might be emphasizing the correlation between the periodontal disease and deficiency in Vit. D.

Background: A consensus was reached for a new classification system for periodontal and peri-implant diseases and conditions and was proposed by a group of world experts in 2017. Since then, there have been ongoing debates among periodontists regarding the application of the new classification. This study aims to shed light on the current understanding of the new classification among Egyptian periodontists. Methods: This cross-sectional survey study was performed using an anonymous manually distributed questionnaire in various universities in Egypt. The validated questionnaire included 15 questions – 13 multiple choice questions with a Likert scale and two open ended questions, in addition to demographic data of the participant. Qualitative data were presented as frequencies and percentages, and binary and ordinal logistic regression analyses were performed. Results: The clarity of the new classification was the only significant predictor for satisfaction. An increase in clarity scores was directly associated with an increase in satisfaction scores (odds ratio = 5.521, 95% CI = 2.198 – 8.844, P-value = 0.001). Only 24.2% of the participants actually applied the new classification. There was a high approval rate on the introduction of “health on reduced periodontium” and the classification of peri-implant conditions. However, there was a huge dissatisfaction with applying the staging and grading system as well as the omission of aggressive periodontitis. Conclusions: This survey has identified important gaps between theory and practice and bridging these gaps by revising the controversial points would help develop a clearer, simpler system for clinicians to improve patients’ oral health.

Background: One of the most common esthetic concerns in dentistry is gingival recession (GR), and despite the various treatment strategies for root coverage, multiple recessions still present a great challenge, especially Miller Class III/RT2. Thus, this study aimed to compare the effect of platelet-rich fibrin (PRF) versus connective tissue graft (CTG) using vestibular incision subperiosteal tunnel access (VISTA) in patients with Miller class III/RT2 multiple recessions for root coverage. Methods: Twenty-eight patients with multiple Class III/RT2 gingival recessions were randomly allocated to two equal groups – group 1 (VISTA+PRF) and group 2 (VISTA+CTG). Recession depth (RD) and width (RW), probing depth (PD), clinical attachment level (CAL), gingival thickness, keratinized tissue width, and root coverage esthetic score (RES) were measured at 0, 3, and 6 months. Statistical analysis was performed using repeated measures analysis of variance (ANOVA). Bonferroni’s post-hoc test was used for pair-wise comparisons when ANOVA was significant. For non-parametric data, the Mann-Whitney U test was used to compare between the two groups. Results: Within each group, a significant difference from baseline to six months was found. However, between groups, the results for the VISTA+CTG group significantly surpassed the VISTA+PRF group in most clinical outcomes; gingival recession depth (0.5 [0.25-1.75] and 1.33 [0.75-2], respectively), and width (1 [0.38-3.75] and 2.33 [1.33-3], respectively), gingival thickness at three and six months (2.62±0.36 and 2.63±0.36, respectively) and (1.85±0.2 and 1.87±0.18, respectively), and keratinized tissue width (3.98±0.72 and 3.33±0.56, respectively). However, CAL and PD showed a statistically insignificant difference when comparing both groups. Conclusion: The use of CTG is superior to PRF in root coverage of Miller Class III/RT2 when the VISTA technique is used. Connective tissue grafts can be considered the gold standard for root coverage.