The association between visual function and retinal structure in chronic central serous chorioretinopathy

Sugiura, Aya; Fujino, Ryosuke; Takemiya, Nobuko; Shimizu, Kimiko; Murata, Hiroshi; Inoue, Tatsuya; Obata, Ryo; Asaoka, Ryo

doi:10.1038/s41598-017-16339-9

Cited by 17 publications

(18 citation statements)

References 43 publications

(27 reference statements)

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“…Chiba et al showed that the BCVA was significantly correlated with the foveal sensitivity in macular thickening disorders [ 42 ]. Sugiura et al also reported similar results between the BCVA and macular retinal sensitivity, but this significant relationship was not observed when the retinal sensitivity was calculated from a wider retinal area in eyes with chronic CSC [ 43 ].…”

Section: Discussionmentioning

confidence: 93%

Long-Term Effects of Half-Time Photodynamic Therapy on Retinal Sensitivity in Eyes with Chronic Central Serous Chorioretinopathy

Iwase

Yokouchi

Kitahashi

et al. 2020

BioMed Research International

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The purpose of this study was to evaluate the long-term effects of half-time photodynamic therapy (PDT) on the retinal sensitivity in eyes with chronic central serous chorioretinopathy (CSC). Twenty-two eyes of 22 patients with chronic CSC were studied. PDT was applied with full-dose verteporfin and half-time laser duration. The best-corrected visual acuity (BCVA) and retinal sensitivity in the central 2 and 10 degrees were evaluated at the baseline, and at 12 and 24 months after the half-time PDT. The retinal sensitivity was determined by Macular Integrity Assessment microperimetry (MAIA, Centervue, Padova, Italy). The results showed that the mean retinal sensitivities in the central 2 and 10 degrees were significantly improved at 12 months (25.6±2.79 dB, median; 26.11 dB, 25.6±2.25 dB, median; 25.65 dB, respectively; P<0.001) and at 24 months (26.3±2.62 dB, median; 27.38 dB, 26.6±2.21 dB, median; 27.45 dB, respectively; P<0.001) after the treatment compared to that at the baseline (19.2±3.93 dB, median; 19.34 dB, 20.9±2.92 dB, median; 20.9 dB, respectively). The BCVA was also significantly improved from 0.18±0.19 median; 0.15 logarithm of the minimum angle of resolution (logMAR) units at the baseline to 0.07±0.15 median; 0 logMAR units at 12 months (P<0.001) and to 0.049±0.16 median; -0.039 logMAR units at 24 months (P<0.001). We conclude that half-time PDT results in a significant improvement of the mean central retinal sensitivity for at least 24 months in eyes with chronic CSC. Thus, half-time PDT is beneficial in resolving chronic CSC for a relatively long period.

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Section: Discussionmentioning

confidence: 93%

Long-Term Effects of Half-Time Photodynamic Therapy on Retinal Sensitivity in Eyes with Chronic Central Serous Chorioretinopathy

Iwase

Yokouchi

Kitahashi

et al. 2020

BioMed Research International

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“…A. Sugiura, R. Fujino, N. Takemiya не выявили наличия корреляции между центральной светочувствительностью и остротой зрения после лечения. Однако следует отметить, что авторы оценивали общую светочувствительность, которая может иметь высокие значения на периферии в зоне прилегания нейроэпителия [25]. В связи с этим в данном исследовании мы оценивали центральную фовеальную светочувствительность, измеренную в 5 точках.…”

Section: результаты и обсуждениеunclassified

“…В исследовании A. Sugiura и соавт. была установлена взаимосвязь высоты отслойки нейроэпителия с центральной светочувствительностью, но в рамках нашего исследования корреляция между этими параметрами не рассматривалась [25].…”

Section: результаты и обсуждениеunclassified

The Personalized Approach to the Chronic Central Serous Chorioretinopathy Treatment Based on the Navigated Micropulse Laser Technology

et al. 2019

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The Purpose— to develop the technology and to evaluate the clinical results of personalized laser treatment of patients with chronic central serous chorioretinopathy (CSC) in a micropulse mode with individual selection of energy parameters on the navigation system Navilas 577s.Patients and Methods. 19 patients (22 eyes) with CSC after micropulse laser treatment were analyzed. The initial best corrected visual acuity (BCVA) was 0.4 to 1.0. According to OCT, the height of the detachment of the neurosensory retina varied from 83 to 259 microns. Retinal sensitivity of the central zone was from 20.2 to 29.7 dB. Before laser treatment were individually selected the optimal energy parameters for each patient. The treatment was performed on a Navilas 577s laser system. The follow-up were 1 and 3 months.Results. 1 month after treatment the positive dynamics of functional and anatomical results in all patients was observed. Mean BCVA increased in the group to 0.81 ± 0.04. The central retinal sensitivity raised on average in the group up to 25.7 ± 0.6 dB. After 3 months, mean BCVA was 0.96 ± 0.02. Mean central retinal sensitivity increased to 26.4 ± 0.57 dB. The study revealed a high correlation between visual acuity and the central retinal thickness (0.72) and medium correlation between foveal retinal sensitivity and central retinal thickness in fovea (0.60), respectively. The correlation among visual acuity, retinal sensitivity and the symptom’s duration of the disease is negative medium (-0.63) and significant (-0.72), respectively.Conclusions. The developed personalized technology of laser treatment of chronic central serous chorioretinopathy with a micropulse mode with an individual selection of energy parameters on the Navilas 577s navigation system showed high clinical efficiency and safety. It has been established that in the course of the longstanding duration of the disease irreversible changes in the chorioretinal complex structure occured, thinning of the foveal photoreceptors layer leading to a decrease in the central retinal sensitivity and visual acuity, which substantiate the necessity for early and maximally functional-saving treatment.

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“…Most initial retinal detachments in CSC resolve spontaneously 10 , 11 ; however, chronic CSC can also be experienced where patients often complain of visual symptoms, such as decreased visual sensitivity, metamorphopsia, and central scotoma 12 – 14 , despite the preserved VA. Agreeing with this, we have recently shown that it was advantageous to assess the visual function in chronic CSC using the white-on-white (WW) visual field (VF) testing (with microperimetry) rather than using VA alone 15 . The retinal sensitivities, but not VA, were well associated with SRD measurements obtained by optical coherence tomography (OCT) 15 .…”

Section: Introductionmentioning

confidence: 99%

“…Agreeing with this, we have recently shown that it was advantageous to assess the visual function in chronic CSC using the white-on-white (WW) visual field (VF) testing (with microperimetry) rather than using VA alone 15 . The retinal sensitivities, but not VA, were well associated with SRD measurements obtained by optical coherence tomography (OCT) 15 .…”

Section: Introductionmentioning

confidence: 99%

Short wavelength automated perimetry and standard automated perimetry in central serous chorioretinopathy

Zhou

Asaoka

Inoue

et al. 2020

Sci Rep

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Short wavelength automated perimetry (SWAP) is known for detecting the early reduction of retinal sensitivity (RS) in glaucoma. It’s application in retinal diseases have also been discussed previously. We investigated the difference in RS measured between standard white-on-white automated perimetry (WW) and blue-on-yellow SWAP in central serous chorioretinopathy (CSC). The overall RS (W-RS, S-RS) as well as the RS inside and outside of the serous retinal detachment (SRD) region were investigated in 26 eyes of 26 CSC patients using WW and SWAP. The central retinal thickness, central choroidal thickness, SRD area (SRDa), and SRD height at the fovea were measured using optic coherence tomography. RS inside the SRD region was lower than that of outside for both perimetries (both p < 0.001). The difference between RS inside and outside of the SRD region was greater in SWAP compared to WW (p < 0.001). Univariate analysis revealed significant correlations between SRDa and both W-RS and S-RS (both p < 0.001); moreover, multivariate analysis indicated that only S-RS was selected as the optimal model for SRDa. Our study demonstrated that SWAP was detected the decrease in RS more accurately than WW in CSC. These results may suggest the usefulness of SWAP for detecting change of retinal function in CSC.

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The association between visual function and retinal structure in chronic central serous chorioretinopathy

Cited by 17 publications

References 43 publications

Long-Term Effects of Half-Time Photodynamic Therapy on Retinal Sensitivity in Eyes with Chronic Central Serous Chorioretinopathy

Long-Term Effects of Half-Time Photodynamic Therapy on Retinal Sensitivity in Eyes with Chronic Central Serous Chorioretinopathy

The Personalized Approach to the Chronic Central Serous Chorioretinopathy Treatment Based on the Navigated Micropulse Laser Technology

Short wavelength automated perimetry and standard automated perimetry in central serous chorioretinopathy

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