The association between tumour progression and vascularity in the oral mucosa

Pazouki, Sima; Chisholm, D. M.; Adi, M. M.; Carmichael, George; Farquharson, Michael J.; Ogden, Graham S.; Schor, Seth L.; Schor, Ana M.

doi:10.1002/(sici)1096-9896(199709)183:1<39::aid-path1088>3.3.co;2-c

Cited by 29 publications

(46 citation statements)

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“…This observation is potentially important for prognostic reasons and treatment purposes. Angiogenesis assessment might be useful not only in stratifying patients for different (adjuvant) treatment regimens but also in predicting their response to chemotherapy (Koukourakis, 2001;Mattern, 2001), to anti-angiogenic therapies and identifying the precancerous lesions (Pazouki et al, 1997). Figure 1 Results of the meta-analysis of the studies using factor VIII.…”

Section: Discussionmentioning

confidence: 99%

“…Contradictory results in the literature may also be explained by variations in vascularity between areas in different sections from the same block or among blocks taken from the same tumour (de Jong et al, 1995) and by the methods used to measure vascularity (Pazouki et al, 1997). In large tumours, it could be necessary to examine multiple blocks in order to determine the overall vascularity of the tumour.…”

Section: Discussionmentioning

confidence: 99%

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The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis

et al. 2002

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In order to determine whether angiogenesis is a prognostic marker in lung cancer, we performed a systematic review of the literature to assess the prognostic value on survival of microvessel count in patients with lung cancer. Published studies were identified by an electronic search in order to aggregate survival results, after a methodological assessment using a quality scale designed by the European Lung Cancer Working Party. To be eligible, a study had to deal with microvessel count assessment in lung cancer patients on the primary site and to provide survival analysis according to microvessel count expression. Microvessel count has been assessed on surgical samples by immunohistochemistry using factor VIII in 14 studies, CD34 in 10 and CD31 in eight. Respectively 1866, 1440 and 1093 non-small cell lung cancer patients were considered. The overall median quality scores were respectively 52, 59 and 59% for studies assessing microvessel count via factor VIII, CD34 and CD31, without significant difference between studies evaluable or not for meta-analysis nor between studies with significant or non significant results. Seven 'factor VIII' studies, nine 'CD34' and seven 'CD31' provided sufficient data allowing a metaanalysis on survival and were evaluable for results aggregation. This showed that a high microvessel count in the primitive lung tumour was a statistically significant poor prognostic factor for survival in non small cell lung cancer whatever it was assessed by factor VIII (HR: 1.81; 95% CI: 1.16 -2.84), CD34 (HR: 1.99; 95% CI: 1.53 -2.58) or CD31 (HR: 1.80; 95% CI: 1.10 -2.96). Variations in survival among the individual studies can be explained in addition to patients selection criteria by the heterogeneous methodologies used to stain and count microvessels: different antibody clones, identification of 'hotspots', Weidner or Chalkey counting method, cut-off selection. Microvessel count, reflecting the angiogenesis, appears to be a poor prognostic factor for survival in surgically treated non small cell lung cancer but standardisation of angiogenesis assessment by the microvessel count is necessary.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis

et al. 2002

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“…vascularity is estimated by the microvascular volume, rather than coefficients (r) were as follows: (A) a-MVD v h-MVD r= 0.78; density (Pazouki et al, 1997). Therefore, in this study we have h-MVD r= 0.52; (C) MVV v a-MVD r= 0.58.…”

Section: Analysis Of Survivalmentioning

confidence: 97%

“…It has previously been suggested that contradictory results in the literature may be explained by variations in vascularity among blocks taken from the same tumour (van Hoef et al, 1993;De Jong et al, 1995) and by the methods used to measure vascularity (Pazouki et al, 1997). As quantitative methods in diagnostic pathology must be reliable and straightforward, we have attempted to clarify this situation by measuring vascularity in a welldefined group of NSCLC patients, using three different methods.…”

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confidence: 98%

Relationship between vascularity, age and survival in non-small-cell lung cancer

Chandrachud

Pendleton²,

Chisholm³

et al. 1997

Br J Cancer

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Summary Lung tumours in the elderly show reduced growth potential; impaired angiogenesis may contribute to this phenomenon. Recent studies have suggested that the angiogenic potential of a tumour may be inferred by the vascularity measured in histological sections. The purpose of this study has been to determine whether vascularity is related to age, survival or other clinical parameters in resected non-smallcell lung cancer (NSCLC). A group of 88 consecutive patients with a follow-up period of at least 5 years was selected. The group exhibited a wide age range (37-78 years) and similar survival characteristics to those of the general NSCLC population. Tumour sections were stained with a pan-endothelial antibody (vWF) and vascularity was quantitated, without knowledge of the clinical details, by three methods: highest microvascular density; average microvascular density; and average microvascular volume. The results were analysed by non-parametric statistical tests. A correlation was found between all three methods of quantitation. Vascularity was not associated with age, sex, tumour type, stage, volume, size (TNM-T) nodal status (TNM-N) or survival. However, survival time was generally longer for patients with higher vascularity, reaching borderline significance (P = 0.06) for the average microvascular density values. Higher tumour volume (P = 0.02) and stage (P = 0.05) were associated with lower survival times. Using multivariate survival analysis, tumour volume was the only factor related to survival. We conclude that vascularity is not associated with age and has no significant prognostic value in NSCLC.

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“…Many authors have reported, on brain, skin, kidney and lung, that endothelial cells express it to varying degrees (Rabb et al, 1996;Navratil et al, 1997;Pazouki et al, 1997;Passalidou et al, 2002) although in one study of normal human breast tissue the endothelium was negative for aVb3 (Gasparini et al, 1998). While it is well established that endothelial expression of aVb3 is essential for angiogenesis induced by basic fibroblastic growth factor or tumour necrosis factor (Brooks et al, 1994;Friedlander et al, 1995), it has also been found that it can be upregulated in resting endothelium by a variety of biological stimuli (Tang et al, 1994) and that it is also present on resting endothelial cells (Conforti et al, 1992).…”

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confidence: 99%

Vascular patterns in reactive lymphoid tissue and in non-Hodgkin's lymphoma

et al. 2003

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The few studies published on angiogenesis in lymphoma have raised the question of whether or not microvessel density (MVD) is associated with more aggressive disease and have reported the observation that in follicular lymphomas, vessels are mature rather than immature. We investigated MVD and the vascular phenotype within follicular or diffuse large B-cell lymphomas, reactive nodes and tonsils. Vascular phenotype was defined by the expression or loss of reactivity to the antibody LH39 (detecting the LH39 laminin epitope of the basement membrane in mature vessels) and by detection of aVb3 (expressed on immature vessels). In reactive nodes and in follicular lymphomas, MVD was higher in the paracortex than in germinal centres or in neoplastic follicles. However, in neoplastic follicles an increase in aVb3-positive endothelium suggested the activation of an angiogenic pathway different from that present in the reactive follicles. In large B-cell lymphomas, MVD was higher than in reactive and neoplastic follicles but lower than in the reactive paracortex. The number of immature vessels (LH39 negative) and of aVb3-positive vessels was higher than in reactive lymph nodes and follicular lymphoma suggesting that a switch to a different angiogenic pathway has occurred. Finally, we have demonstrated that within reactive and neoplastic follicles vascular regression is occurring, perhaps constraining the growth of reactive follicles alongside other phenomena such as apoptosis. Vascular regression was previously believed to occur in adults only in ovarian and endometrial tissue. We conclude that different types of angiogenesis are present in follicular lymphomas and large B-cell lymphomas. This has implications for possible future therapies.

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The association between tumour progression and vascularity in the oral mucosa

Cited by 29 publications

References 0 publications

The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis

The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis

Relationship between vascularity, age and survival in non-small-cell lung cancer

Vascular patterns in reactive lymphoid tissue and in non-Hodgkin's lymphoma

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