The association between traumatic experiences and suicide attempt in patients treated at the Hospital de Pronto Socorro in Porto Alegre, Brazil

Zatti, Cleonice; Guimarães, Luciano Santos Pinto; Soibelman, Mauro; Semensato, Márcia Rejane; Bastos, André Goettems; Calegaro, Vítor Crestani; Freitas, Lúcia Helena Machado

doi:10.1590/2237-6089-2018-0112

Cited by 5 publications

(6 citation statements)

References 25 publications

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“…SA is typically associated (but not synonymous) with a more severe illness presentation, which may account for some of the observed relationships. SA individuals are more likely to abuse substances [51], report more severe psychiatric symptoms [52] and trauma [53], and come from lower socioeconomic backgrounds [54], which may cumulatively contribute to accelerated aging [16,[55][56][57]. Indeed, BD/SA showed many differences in clinical variables, including longer length of illness and higher numbers of comorbidities and hospitalizations than BD/non-SA.…”

Section: Discussionmentioning

confidence: 99%

“…When covarying for lithium and medication use separately, the significant difference in GrimAgeAccel between BD groups remained in both cohorts (Tables 4 and S5) , suggesting that medication use is not a significant confounder in our results. Nevertheless, we cannot exclude the possibility that other unmeasured factors are responsible for this difference, including participants’ early life or cumulative trauma, which is linked to SA risk [53] and contributes to biological aging [57,60]. SA itself or genetic liability for suicidal behavior may also directly contribute to premature aging, although recent genetic data suggest that EA is largely independent of genetic risk [61].…”

Section: Discussionmentioning

confidence: 99%

“…The copyright holder for this this version posted November 18, 2022. ; https://doi.org/10.1101/2022.11.15.22282309 doi: medRxiv preprint severe psychiatric symptoms [52] and trauma [53], and come from lower socioeconomic backgrounds [54], which may cumulatively contribute to accelerated aging [16,[55][56][57]. Indeed, BD/SA showed many differences in clinical variables, including longer length of illness and higher numbers of comorbidities and hospitalizations than BD/non-SA.…”

Section: (Which Was Not Certified By Peer Review) Preprintmentioning

confidence: 99%

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Association between the Epigenetic Lifespan Predictor GrimAge and History of Suicide Attempt in Bipolar Disorder

Lima¹,

Kovács

Mirza

et al. 2022

Preprint

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Bipolar disorder (BD) has been previously associated with premature mortality and aging, including acceleration of epigenetic aging. Suicide attempts (SA) are greatly elevated in BD and are associated with decreased lifespan, biological aging, and poorer clinical outcomes. We investigated the relationship between GrimAge, an epigenetic clock trained on time-to-death and associated with mortality and lifespan, and SA in two independent cohorts of BD individuals (discovery cohort - controls (n=50), BD individuals with (n=77, BD/SA) and without (n=67, BD/non-SA) lifetime history of SA; replication cohort - BD/SA (n=48) and BD/non-SA (n=47)). An acceleration index for the GrimAge clock (GrimAgeAccel) was computed from blood DNA methylation (DNAm) and compared between groups with multiple general linear models. Differences in epigenetic aging from the discovery cohort were validated in the independent replication cohort. In the discovery cohort, controls, BD/non-SA, and BD/SA significantly differed on GrimAgeAccel (F=5.424, p=0.005), with the highest GrimAgeAccel in BD/SA (p=0.004, BD/SA vs. controls). Within the BD individuals, BD/non-SA and BD/SA differed on GrimAgeAccel in both cohorts (p=0.008) after covariate adjustment. Finally, DNAm-based surrogates revealed possible involvement of plasminogen activator inhibitor 1, leptin, and smoking pack-years in driving accelerated epigenetic aging. These findings pair with existing evidence that not only BD, but also SA, may be associated with an accelerated biological aging and provide putative biological mechanisms for morbidity and premature mortality in this population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: (Which Was Not Certified By Peer Review) Preprintmentioning

confidence: 99%

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Association between the Epigenetic Lifespan Predictor GrimAge and History of Suicide Attempt in Bipolar Disorder

Lima¹,

Kovács

Mirza

et al. 2022

Preprint

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“…This form of violence demonstrates to children that their caregivers do not consider them to be worthy of love, which makes them feel unwanted. In this sense, according to a metaanalysis conducted by Zatti et al, 34 discrete forms of childhood trauma, such as cases of emotional neglect and a broken home, can significantly contribute to suicide attempts in adulthood.…”

Section: Discussionmentioning

confidence: 99%

Relationship between childhood trauma, parental bonding, and defensive styles and psychiatric symptoms in adult life

Waikamp

Serralta

Ramos-Lima

et al. 2021

Trends Psychiatry Psychother

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Introduction A relationship between different types of childhood trauma, parental care, and defensive styles and development of psychiatric symptoms in adulthood is proposed in this study. Understanding the nature of this association is essential to assist psychotherapists who treat patients with a history of past trauma. This study aims to examine the associations between childhood trauma, parental bonding, and defensive styles and current symptoms in adult patients who sought care at an analytical psychotherapy clinic. Methods The sample comprised 197 patients from an analytically oriented psychotherapy clinic. Participants responded to four self-report instruments that assessed, respectively, presence and frequency of several types of early trauma, type of parental attachment, styles of defenses, and current symptoms encompassing a wide variety of psychopathological syndromes. Results Only 5% of patients reported not having experienced any traumatic experience in childhood. Several traumas such as emotional and physical abuse, emotional neglect, and physical neglect showed positive and significant associations with several dimensions of current symptoms, and also with parental bonding and defensive styles. When analyzed together with the other variables, defensive styles explained the level of psychological suffering caused by the symptoms. Conclusions This study offers additional support for understanding the associations between childhood trauma, parental bonding styles, and defense styles and the psychiatric symptoms of patients in analytically oriented psychotherapy.

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“…Quantitative data analysis was performed in PASW (SPSS) version 18. The sociodemographic characteristics of the sample have been presented elsewhere by Zatti et al 12 A generalized estimating equation (GEE) model 13,14 was used to compare the mean scores for each STAXI-2 factor between groups. This model was used due to the sample pairing method (1 case for 2 controls of the same gender and age).…”

Section: Discussionmentioning

confidence: 99%

Association between anger expression and attempted suicide at a general emergency hospital in the south of Brazil

Zatti¹,

Oliveira²,

Guimarães³

et al. 2021

Trends Psychiatry Psychother

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Introduction: Suicide is one of the leading causes of death in the world. For every person who commits suicide, twenty or more have attempted to take their own lives. The emotional state of anger is often associated with suicidal behavior. However, this association needs to be further clarified.Objectives: This study sought to investigate the profiles of traits and expressions of anger in inpatients admitted to a general emergency hospital after surviving a suicide attempt. Methods: In this case-control study, a sample of 28 suicide survivors was matched for sex, age, and educational level with 56 controls. The State-Trait Anger Expression Inventory-2 was used to measure anger traits and expression. Results: Suicide survivors scored higher for anger traits and expression and lower for anger control than the control group. They also had lower levels of state anger and willingness to express anger verbally than the control group. Conclusions: Patients who attempted suicide and had high scores for anger expression (in and out) are inclined to have extreme difficulty in interpersonal relationships and rigidity towards change and are at higher risk of developing psychopathologies.

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The association between traumatic experiences and suicide attempt in patients treated at the Hospital de Pronto Socorro in Porto Alegre, Brazil

Cited by 5 publications

References 25 publications

Association between the Epigenetic Lifespan Predictor GrimAge and History of Suicide Attempt in Bipolar Disorder

Association between the Epigenetic Lifespan Predictor GrimAge and History of Suicide Attempt in Bipolar Disorder

Relationship between childhood trauma, parental bonding, and defensive styles and psychiatric symptoms in adult life

Association between anger expression and attempted suicide at a general emergency hospital in the south of Brazil

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