The association between thyroid function and incidence of metabolic syndrome in euthyroid subjects: Tianjin chronic low‐grade systemic inflammation and health cohort study

Gu, Yeqing; Wang, Yanyan; Zhang, Qing; Liu, Li; Meng, Guang; Yao, Zhanxin; Wang, Hongmei; Yang, Xia; Bao, Xue; Shi, Hongbin; Wang, Honglei; Sun, Shaomei; Wang, Xing; Zhou, Ming; Jia, Qiyu; Song, Kun; Niu, Kaijun

doi:10.1111/cen.13576

Cited by 16 publications

(11 citation statements)

References 40 publications

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“…The mean of BMI of cases was 26.62 ± 2.69 kg/m 2 and in controls it was 24.26 ± 1.56 kg/m 2 . A similar study carried out by Yeqing Gu et al; 15 found that BMI of cases was in range of 25.0-25.3 kg/m 2 and BMI in control group was found to be 23.3 to 25.1 kg/m 2 . Frank M. Bengel et al 16 found that, in cases of hypothyroidism BMI ranges between 25.54 ± 2.18 kg/m2.…”

Section: Discussionsupporting

confidence: 56%

Carotid Intima-Media Thickness (C-Imt) in Hypothyroidism- Early Assessment of Subclinical Atherosclerosis

Beralkar¹,

Acharya²,

Gagneja³

et al. 2018

jebmh

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BACKGROUND The present study entitled "Carotid Intima Media Thickness in Hypothyroidism" was conducted in the department of General medicine, A.V.B.R.H and J.N.M.C, Sawangi, Meghe, Wardha. C-IMT was measured by recording ultrasonographic images of both the left and right common carotid artery with a 7-MHz linear array transducer. Patients were examined in the supine position, with the head turned 45° from the side during the scanning procedure. The aim of the study is to evaluate carotid intima media thickness (C-IMT) in hypothyroidism. MATERIALS AND METHODS The study included 100 cases of newly detected hypothyroidism not on thyroid replacement therapy, and 50 matched healthy controls. Body mass index (BMI), thyroid profile, lipids, blood pressure and the mean of C-IMT were determined. RESULTS Mean values of C-IMT, triglycerides, and total cholesterol were significantly high in hypothyroidism group versus controls. Carotid intima-media thickness was significantly increased in SCH and overt hypothyroidism group as compared to controls (p <0.001). On comparing all independent variables like BMI, lipids and blood pressure with dependent variable C-IMT, statistically significant difference was found with FT4 (p=0.024), TSH (p=0.041) and with HDL (p=0.021). CONCLUSION In overt and subclinical hypothyroidism groups, values of diastolic blood pressure (DBP), triglycerides (TG), low density lipoprotein (LDL) were deranged. All these may contribute to atherosclerosis and an increase in C-IMT, causing potential risk for future cardiovascular disease, stroke. So, hypothyroidism group having deranged lipid profile and other risk factors like obesity should be screened for atherosclerosis by measuring C-IMT. This group can be targeted for primary prevention of coronary artery diseases (CAD) and its early management like lipid lowering agents apart from being treated for hypothyroidism.

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Section: Discussionsupporting

confidence: 56%

Carotid Intima-Media Thickness (C-Imt) in Hypothyroidism- Early Assessment of Subclinical Atherosclerosis

Beralkar¹,

Acharya²,

Gagneja³

et al. 2018

jebmh

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“…Serum levels of thyroid hormones (THs) have been associated with MetS components since they target the same metabolic pathways ( 5 , 7 ). THs are of major importance for metabolism and energy balance.…”

mentioning

confidence: 99%

Thyroid hormone levels are associated with metabolic components: a cross-sectional study

Punda¹,

Škrabić²,

Torlak³

et al. 2020

Croat Med J

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Aim To analyze the association of thyroid function and hormone levels with metabolic syndrome (MetS) and its components. Methods This cross-sectional population-based study involved 2183 Croatian individuals with no history of thyroid disease, hypertension, diabetes, and hyperlipidemia. MetS was diagnosed according to the National Cholesterol Education Program’s Adult Treatment Panel III criteria. Results We found no association between thyroid function groups and the prevalence of MetS and its components. Clinically hypothyroid participants showed significantly higher triceps skinfold measurements than subclinically hypothyroid and euthyroid participants. Furthermore, clinically hypothyroid participants had higher abdominal skinfold thickness than subclinically hypothyroid participants. Otherwise, suprailiac and abdominal skinfold measurements were higher in the subclinically and clinically hyperthyroid group of participants compared with euthyroid and subclinically hypothyroid participants. A strong positive association of thyroid-stimulating hormone (TSH) and strong negative association of free triiodothyronine (fT3) and free thyroxine (fT4) levels with HOMA-IR and cholesterol levels were found. Furthermore, the fT4 level also showed a strong negative association with HDL and triceps skinfold thickness. Conclusions This study supports the standing that TSH, fT3, and fT4 levels are important variables to determine the association of thyroid function with MetS.

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“…Thyroid hormones (TH) are essential for cellular energy homeostasis and regulation. These actions are mediated both through the central nervous system and the direct interaction of TH with peripheral target organs [4]. Abnormal levels of THs alter metabolism and these alterations cause a MetS-like picture [1,4].…”

Section: Introductionmentioning

confidence: 99%

“…These actions are mediated both through the central nervous system and the direct interaction of TH with peripheral target organs [4]. Abnormal levels of THs alter metabolism and these alterations cause a MetS-like picture [1,4]. Studies suggest an association between a high thyroid stimulating hormone (TSH) and (individual components of) the MetS [1,[4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Thyroid Hormones, Metabolic Syndrome and HOMA-IR in People with Obesity or Overweight

Emıroglu

Özdemir

Görpelioğlu

et al. 2022

Clinical Diabetology

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Objective: In the literature the data about the relationship between thyroid hormone (TH) levels and Metabolic Syndrome (MetS) components are conflicting. Our aim was to evaluate the associations between THs and MetS as well as individual components of MetS and homeostatic model assessment of insulin resistance (HOMA-IR) in euthyroid people with obesity and overweight. Materials and methods: Adult patients who presented to Family Medicine Outpatient Clinics of a tertiary hospital between May 2019 and December 2019 with the intention of weight loss were enrolled in this cross-sectional, descriptive study. The data including height, weight, waist circumference, hip circumference, blood pressure (BP), fasting blood glucose (FBG), total cholesterol, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride, thyroid stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), insulin, HOMA-IR, and HbA1c were analyzed. Results: A total of 175 patients, 135 (77.1%) female, 40 (22.9%) male (mean age: 40.8 ± 13.1 years), without known thyroid dysfunction were included. A total of 86 were overweight and 89 were obese. Fifty-nine (33.7%) of the study participants were diagnosed with MetS. Subjects with MetS had significantly higher level of fT3 even within the normal range (p = 0.039). When TSH, fT4 and fT3 values were compared with other metabolic components in the group with MetS, a significant positive correlation was found only between fT4 level and HOMA-IR (Rho = 0.316, p = 0.026). Conclusions: MetS was associated with high normal fT3suggesting differential thyroid hormone metabolism in

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The association between thyroid function and incidence of metabolic syndrome in euthyroid subjects: Tianjin chronic low‐grade systemic inflammation and health cohort study

Abstract: This population-based prospective cohort study suggests that increased serum FT3 level, rather than FT4 and TSH, is an independent predictor for developing MetS in euthyroid subjects.

Cited by 16 publications

References 40 publications

Carotid Intima-Media Thickness (C-Imt) in Hypothyroidism- Early Assessment of Subclinical Atherosclerosis

Carotid Intima-Media Thickness (C-Imt) in Hypothyroidism- Early Assessment of Subclinical Atherosclerosis

Thyroid hormone levels are associated with metabolic components: a cross-sectional study

The Relationship between Thyroid Hormones, Metabolic Syndrome and HOMA-IR in People with Obesity or Overweight

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