The Association Between Three Genetic Variants in MicroRNAs (Rs11614913, Rs2910164, Rs3746444) and Prostate Cancer Risk

Abstract

Background/Aims: MicroRNAs (miRNAs) are a class of small non-coding RNA molecules which play a significant role in transcriptional and translational regulation. Published data on the association between the miRNA SNPs and prostate cancer (PCa) risk are somewhat inconclusive. Methods: We performed a meta-analysis of all available studies including 2,227 patients and 2,331 control subjects to evaluate the impact of three common genetic variants of microRNAs in prostate cancer risk. Odds ratios (ORs) with 95% confidence intervals (CIs) were utilized to investigate the strength of the association. Results: For miR-499 polymorphism, a significant association was observed between the rs3746444 A>G polymorphism and PCa risk in heterozygote comparison and dominant genetic model, in particular in Asian population subgroup. For miR-146a polymorphism, the rs2910164 CC genotype was associated with decreased PCa risk in Asian population in homozygote comparison. In addition, rs2910164 CC genotype had a weekly higher percentage value in subgroup of Gleason score < 7. Similar results were also indicated in localized prostate cancer in subgroup analysis by tumor stage. For miR-196a2 polymorphism, no association was observed between this variant and PCa risk in the overall group. However, in stratified analysis by ethnicity, we found that rs11614913 T allele was a risk factor for Asian PCa patients. Conclusions: Polymorphisms of miR-196a2 rs11614913, miR-146a rs2910164, and miR-499 rs3746444 may contribute to the risk for developing prostate cancer in Asian descendants. Moreover, miR-146a rs2910164 polymorphism was related to PCa prognosis.

Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta‐analysis

“…All four miRNA gene variant associations noteworthy to detect an OR of 1.1 that were also noteworthy (FPRP < 0.2) were included in these 16 comparisons. The other 12 comparisons were miR‐196a2/rs11614913 T vs. C (OR, 1.21; P < .0001); miR‐27a/rs895819 GG vs. AA + AG (OR, 1.49, P < .001) and colorectal cancer ; miR‐196a2/rs11614913 C vs. T (OR, 1.40, P < .00001) and oesophageal cancer ; miR‐146a/rs2910164 G vs. C (OR, 1.15, P < .001); miR‐196a2/rs11614913 T vs. C (OR, 0.77, P < .00001) and gastric cancer ; miR‐146a/rs2910164 C vs. G (OR, 1.19, P < .001) and bladder cancer ; miR‐499/rs3746444 homozygous model (OR, 1.64, P < .001) and breast cancer ; miR‐146a/rs2910164 CC vs. GG + GC (OR, 0.52, P < .001); miR‐499/rs3746444 (OR, 2.07, P < .001) and cervical cancer ; miR‐499/rs3746444 GA vs. AA (OR, 1.60, P < .001) and prostate cancer ; miR‐146a/rs2910164 CC vs. GG (OR, 1.28, P < .001) and lung cancer ; and miR‐499/rs3746444 G vs. A (OR, 1.57, P < .001) and oral squamous cell cancer …”

The miR-146a SNP Rs2910164 and miR-155 SNP rs767649 are risk factors for non- small cell lung cancer in Iranian population

“…However, there is disparate data concerning miR-146a polymorphisms and the susceptibility to other cancers. Hashemi et al showed no statistically signi cant association between miR-146a rs2910164 polymorphisms and prostate cancer in an Iranian population [17] despite a meta-analysis demonstrating that the rs2910164 CC genotype was associated with decreased prostate cancer risk in an Asian population [18]. In addition, whilst the miR-146a rs2910164 GC allele was signi cantly associated with breast cancer in a Pakistani population [9] this was not the case in Azeri subjects from Iran [19].…”

Genetic Variants in miRNAs Are Associated With Risk of Non-syndromic Tooth Agenesis

“…For instance, (Ghanbari et al, 2016) identified associations of rs897984 in miR-4519 and rs11651671 in miR-548at-5p with Parkinson's disease. In addition, rs11614913 in miR-196a2, rs2910164 in miR-146a, and rs3746444 in miR-499 contributed to the risk of prostate cancer in Asian descendants (Mi et al, 2018). However, to the best of our knowledge, the associations between miRNA gene SNPs and TA susceptibility have not been explored.…”