The association between the metabolic syndrome and alanine amino transferase is mediated by insulin resistance via related metabolic intermediates (the Cohort on Diabetes and Atherosclerosis Maastricht [CODAM] study)

Jacobs, Madelon; Greevenbroek, Marleen M.J. van; Kallen, Carla; Ferreira, Isabel; Feskens, Edith J. M.; Jansen, Eugène; Schalkwijk, Casper G.; Stehouwer, Coen D. A.

doi:10.1016/j.metabol.2010.09.006

Cited by 49 publications

(43 citation statements)

References 45 publications

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“…In agreement with a primary role for insulin sensitivity in cholesterol metabolism and, to a considerable extent, in plasma HDL-C concentration variation, we found a diminished ALT level within the “reference” range in hyperalphalipoprotaeinemia cases, a result compatible with other reports relating ALT to insulin sensitivity [37]. …”

Section: Discussionsupporting

confidence: 91%

“…LPL varied inversely with the average arterial blood pressure (g), reinforcing the state of insulin resistance typical of the metabolic syndrome that characterized the low-HDL-C cases; however, potential genetic reasons for this association cannot be ignored [36]. ALT activity associated with the marker of cholesterol body synthesis (desmosterol) (h) likely reinforces the enhanced insulin sensitivity [37] in the high-HDL-C cases. However, as a marker of cholesterol synthesis, desmosterol alone did not differ between the HDL-C concentration groups in our previous investigation, which served as a database for the present report [22].…”

Section: Resultsmentioning

confidence: 99%

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Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects

Leança

Nunes

Panzoldo

et al. 2013

Cardiovasc Diabetol

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BackgroundWe have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult subjects.MethodsWe have measured the activities of several plasma components that are critically influenced by insulin and that control lipoprotein metabolism in subjects with low and high HDL-C concentrations. These parameters included cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP), lecithin cholesterol acyl transferase (LCAT), post-heparin lipoprotein lipase (LPL), hepatic lipase (HL), pre-beta-1HDL, and plasma sterol markers of cholesterol synthesis and intestinal absorption.ResultsIn the high-HDL-C group, we found lower plasma concentrations of triglycerides, alanine aminotransferase, insulin, HOMA-IR index, activities of LCAT and HL compared with the low HDL-C group; additionally, we found higher activity of LPL and pre-beta-1HDL concentration in the high-HDL-C group. There were no differences in the plasma CETP and PLTP activities.ConclusionsThese findings indicate that in healthy hyperalphalipoproteinemia subjects, several parameters that control the metabolism of plasma cholesterol and lipoproteins are related to a higher degree of insulin sensitivity.

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Section: Discussionsupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects

Leança

Nunes

Panzoldo

et al. 2013

Cardiovasc Diabetol

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“…3 In addition, it was shown that there had been a relationship between insulin resistance and NAFLD. 4 On the other hand, cellular, physiological, clinical, and epidemiological studies strongly support a reciprocal relationship between endothelial dysfunction and insulin resistance. 18 Furthermore, several studies have shown that hepatocytes did not carry TC II receptors and that uptake of vitamin B12 by the liver is mediated by endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

Association between Serum Vitamin B12 Levels and the Degree of Steatosis in Patients with Nonalcoholic Fatty Liver Disease

Koplay

Gülcan

Özkan

2011

Journal of Investigative Medicine

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“…NEFA were assessed in EDTA plasma using an enzymatic colorimetric method (NEFA-C; Wako Chemicals, Neuss, Germany) [14]. Blood pressure was measured using an oscillometric precision blood pressure instrument (Maxi-Stabol 3; Speidel & Keller, now Welch Allyn, Skaneateles Falls, NY, USA) [15]. Smoking status, medication use and the prevalence of a history of cardiovascular disease and cardiovascular events were determined by self-report [16].…”

Section: Methodsmentioning

confidence: 99%

Discriminatory ability of simple OGTT-based beta cell function indices for prediction of prediabetes and type 2 diabetes: the CODAM study

et al. 2016

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Aims/hypothesis The hyperglycaemic clamp technique and the frequently sampled IVGTT are unsuitable techniques to assess beta cell function (BCF) in large cohorts. Therefore, the aim of this study was to evaluate the discriminatory ability of simple OGTT-based BCF indices for prediction of prediabetes (meaning impaired fasting glucose and/or impaired glucose tolerance) and type 2 diabetes. Methods Glucose metabolism status was assessed by 2 h 75 g OGTT at baseline (n = 476, mean age 59.2 years, 38.7% women) and after 7 years of follow-up (n = 416) in the Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) study (1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009). Baseline plasma glucose, insulin and Cpeptide values during OGTTs were used to calculate 21 simple indices of BCF. Disposition indices (BCF index × Matsuda index), to compensate for the prevailing level of insulin resistance, were calculated for the BCF indices with the best discriminatory abilities. The discriminatory ability of the BCF indices was estimated by the area under the receiver operating characteristics curve (ROC AUC) with an outcome of incident prediabetes (n = 73) or type 2 diabetes (n = 60 and n = 18 cases, respectively, in individuals who were nondiabetic or had normal glucose metabolism at baseline). Results For incident prediabetes (n = 73), all ROC AUCs were less than 70%, whereas for incident type 2 diabetes, I 30 /I 0 , CP 30 /CP 0 , ΔI 30 /ΔG 30 , ΔCP 30 /ΔG 30 (where I, CP and G are the plasma concentrations of insulin, C-peptide and glucose, respectively, at the times indicated), and corrected insulin response at 30 min had ROC AUCs over 70%. In at-baseline non-diabetic individuals, disposition indices ΔI 30 /ΔG 30 , ΔCP 30 /ΔG 30 and corrected insulin response at 30 min had ROC AUCs of over 80% for incident type 2 diabetes. Moreover, these BCF disposition indices had significantly better discriminatory abilities for incident type 2 diabetes than the Matsuda index alone. Conclusions/interpretation BCF indices reflecting earlyphase insulin secretion have the best ability to discriminate individuals who will develop prediabetes and type 2 diabetes. Of these, ΔCP 30 /ΔG 30 , often referred to as the Cpeptidogenic index, performed consistently well.

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The association between the metabolic syndrome and alanine amino transferase is mediated by insulin resistance via related metabolic intermediates (the Cohort on Diabetes and Atherosclerosis Maastricht [CODAM] study)

Cited by 49 publications

References 45 publications

Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects

Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects

Association between Serum Vitamin B12 Levels and the Degree of Steatosis in Patients with Nonalcoholic Fatty Liver Disease

Discriminatory ability of simple OGTT-based beta cell function indices for prediction of prediabetes and type 2 diabetes: the CODAM study

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