The association between sleep‐disordered breathing and enuresis in children

Jeyakumar, Anita; Rahman, Syed I.; Armbrecht, Eric S.; Mitchell, Ron B.

doi:10.1002/lary.23323

Cited by 86 publications

(77 citation statements)

References 21 publications

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“…Proposed mechanisms for the association between OSA and enuresis include direct mechanical pressure against the bladder that occurs with breathing against an obstructed airway, as well as indirect influence of hormones, such as natriuretic peptides, which are released in response to hemodynamic changes occurring in OSA. 3,4 Obesity is another important risk factor, with studies demonstrating an association with UI in both men and women, and improvement in UI after weight loss. 15 Obesity is also a strong risk factor for OSA, but likely contributes independently of OSA toward UI and enuresis by increasing intra-abdominal pressure and pressure on the bladder.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] In children, enuresis has a higher prevalence among those who have OSA, correlates with disease severity on polysomnography (PSG), and often resolves with treatment of OSA by adenotonsillectomy. 5,6 The reported prevalence of enuresis in adults varies widely, depending on how enuresis is clinically defined and on the population studied.…”

Section: Introductionmentioning

confidence: 99%

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CPAP Treats Enuresis in Adults With Obstructive Sleep Apnea

McInnis

Dodds

Johnsen

et al. 2017

Journal of Clinical Sleep Medicine

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Enuresis, or "bedwetting," in children is associated with obstructive sleep apnea (OSA), and often resolves with treatment of OSA. However, it is poorly understood whether a similar relationship exists in adults. We describe a case series of 5 adult patients in whom OSA was diagnosed by laboratory polysomnography, who presented with enuresis that resolved after treatment with continuous positive airway pressure (CPAP). All cases occurred in the setting of obesity, in addition to other known risk factors for urinary incontinence and enuresis. OSA was diagnosed as severe in all but one case, which was mild. One patient noted recurrence of enuresis that coincided with malfunction of his CPAP machine. There is growing evidence that CPAP therapy may alleviate OSA and enuresis in adults with both conditions. Clinicians should routinely ask about enuresis in patients suspected of having OSA. A systematic study of the association between enuresis and OSA in adults is warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

CPAP Treats Enuresis in Adults With Obstructive Sleep Apnea

McInnis

Dodds

Johnsen

et al. 2017

Journal of Clinical Sleep Medicine

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“…Monosymptomatic primary nocturnal enuresis (NE) is considered one of the morbidities associated with SDB and its treatment by adenotonsillectomy or other therapeutic interventions such as nasal corticosteroids or rapid maxillary expansion is accompanied by resolution or reduced frequency of enuresis episodes (1)(2)(3)(4)(5).…”

mentioning

confidence: 99%

Nocturnal enuresis is associated with moderate-to-severe obstructive sleep apnea in children with snoring

et al. 2014

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Background: Conflicting data suggest that prevalence of monosymptomatic primary nocturnal enuresis (NE) increases with increasing severity of obstructive sleep apnea (OSA) in childhood and especially in girls. We hypothesized that NE is associated with increased risk of moderate-to-severe OSA (obstructive apnea-hypopnea index (AHI) >5 episodes/hour) among children with snoring. Methods: Data of children (≥5 y old) with snoring who were referred for polysomnography over 12 y were reviewed. results: Data of 525 children with mean age (±SD) 7.5 (± 2.2) y and median obstructive AHI (10th-90th percentiles) 1.9 (0.4-7.3) episodes/hour were analyzed. Three hundred and fifty-five children (67.6%) had NE and 87 (16.6%) had moderate-to-severe OSA. There was no interaction between NE and gender regarding the association with moderate-to-severe OSA (P > 0.05). NE was associated significantly with presence of moderate-to-severe OSA after adjustment for tonsillar hypertrophy, obesity, gender, and age (adjusted odds ratio = 1.92 (1.08-3.43); P = 0.03). Presence of NE had high sensitivity (78.2%) and low positive predictive value (19.2%) for detecting moderate-to-severe OSA and low specificity (34.5%) and high negative predictive value (88.8%) for ruling it out. conclusion: Children with snoring and without NE referred for polysomnography are less likely to have moderate-tosevere OSA compared to those with NE.

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“…Adenotonsillectomy is associated with a significant improvement in enuresis in children with SDB. There is a need for randomized controlled trials to look at the role adenotonsillectomy in children with SDB and enuresis [16].…”

Section: Discussionmentioning

confidence: 99%

Delayed Sleep Phase Disorder in Children With Non-Monosymptomatic Primary Nocturnal Enuresis

et al. 2015

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Background: Delayed sleep phase disorder (DSPD), a circadian rhythm disorder, involves a significant, persistent, and intractable phase shift in sleep-wake schedule (later sleep onset and wake time) that conflicts with the individual's normal school, work, and/or lifestyle demands. Nocturnal enuresis (NE) is one of the most frequent pediatric pathologies. The prevalence of primary nocturnal enuresis (PNE) is around 9% in children aged 5 -10 years and about 40% of them have one or more episodes per week.

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The association between sleep‐disordered breathing and enuresis in children

Abstract: SDB in children is associated with nocturnal enuresis. T&A is associated with a significant improvement in enuresis in children with SDB. There is a need for randomized controlled trials to look at the role of T&A in children with SDB and enuresis.

Cited by 86 publications

References 21 publications

CPAP Treats Enuresis in Adults With Obstructive Sleep Apnea

CPAP Treats Enuresis in Adults With Obstructive Sleep Apnea

Nocturnal enuresis is associated with moderate-to-severe obstructive sleep apnea in children with snoring

Delayed Sleep Phase Disorder in Children With Non-Monosymptomatic Primary Nocturnal Enuresis

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