The association between skin autofluorescence and mean deviation in patients with open-angle glaucoma

Himori, Noriko; Kunikata, Hiroshi; Kawasaki, Ryo; Shiga, Yukihiro; Omodaka, Kazuko; Takahashi, Hidetoshi; Miyata, Toshio; Nakazawa, Toru

doi:10.1136/bjophthalmol-2016-309504

Cited by 8 publications

(10 citation statements)

References 22 publications

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“…These accumulations contributed to glaucomatous optic neuropathy [ 36 , 37 ]. Several studies have assessed AGEs in patients with glaucoma [ 21 , 51 , 52 ]. Himori et al reported that higher sAF levels were associated with worse visual fields in young patients with OAG (PG and normal tension glaucoma (NTG)) [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Advanced Glycation End Product Accumulation in Subjects with Open-Angle Glaucoma with and without Exfoliation

et al. 2020

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Advanced glycation end products (AGEs), which are the products of a non-enzymatic reaction between reducing sugars and other macromolecules, are critical in aging, as well as metabolic and degenerative diseases. To assess the involvement of AGEs in glaucoma, skin autofluorescence (sAF) level, which is a measurement of AGEs’ accumulation, was compared among Japanese patients with glaucoma (316 with primary open-angle glaucoma (PG) and 127 exfoliation syndrome and glaucoma (EG)) and controls (133 nonglaucomatous controls) (mean age 71.6 ± 12.8 years, 254 men and 322 women). The sAF values were estimated from the middle fingertip using a 365 nm light-emitting diode for excitation and detection at 440 nm emission light. The estimated AGE values (arbitrary unit) were 0.56 ± 0.15, 0.56 ± 0.11, and 0.61 ± 0.11 in the control, PG, and EG groups, respectively (p < 0.0001, analysis of variance); and were significantly higher in the EG group than the control (p = 0.0007) and PG (p < 0.0001) groups. After adjustment for various demographic parameters by multivariate analyses, male sex (standard β = 0.23), EG (0.19), and diabetes (0.09) were associated with higher AGE levels; PG (−0.18) and smoking (−0.19) were associated with lower AGE levels. Age, visual acuity, intraocular pressure, glaucoma medications, lens status, and systemic hypertension were not associated with AGEs. The high AGE level in EG suggested that specific oxidation and glycation mechanisms underlie the glaucoma pathogenesis associated with pseudoexfoliation syndrome.

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Section: Discussionmentioning

confidence: 99%

Advanced Glycation End Product Accumulation in Subjects with Open-Angle Glaucoma with and without Exfoliation

et al. 2020

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“…73 Our population sample of elderly people has a higher mean age than that observed in other published studies with a cumulative exposure to metabolic activity over a longer period. [22][23][24][25][26][27][28][29][30][31][32]38 Thus, it could have led to a higher accumulation of AGEs in skin collagen and also other fluorophores and chromophores that progressively accumulates with increasing age. Hence, we cannot exclude a higher confounding influence of these non-AGEs components on sAF measurements in our population of elderly people than that observed in younger population sample.…”

Section: Skin Autofluorescence As a Riskmentioning

confidence: 99%

“…Furthermore, the level of AGEs of glaucoma subjects was more than 3 times higher in aqueous humor sample than in blood sample; thus, supporting a potential intraocular generation of oxidative stress in glaucoma subjects. Himori et al 38 recently published a study analyzing the association between sAF and mean deviation values of the visual field test in a Japanese population with OAG and including essentially normal-tension glaucoma cases. They observed that sAF was negatively correlated to mean deviation values of the visual field test; thus, suggesting a role of oxidative stress in the severity of glaucoma and visual field loss.…”

Section: Figurementioning

confidence: 99%

“…Whereas glaucoma is an age-related chronic neurodegenerative disease and oxidative stress may contribute to its pathophysiologic process, the association between AGEs and glaucoma received little attention. 5,[38][39][40] Hence, only a few experimental studies have reported a higher accumulation of AGEs in the optic nerve head, in the retinal ganglion cell layer, in the glia and in the retinal distribution of Müller cells or around blood vessels, thus suggesting a potential role in the pathogenesis of glaucoma. 41,42 However, to date, AGEs have never been evaluated in vivo and in a general population as a potential risk factor for glaucoma.…”

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confidence: 99%

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Autofluorescence of Skin Advanced Glycation End Products as a Risk Factor for Open Angle Glaucoma: The ALIENOR Study

Schweitzer

Cougnard‐Grégoire

Rigalleau

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…Glaucoma is thought to be a multifactorial disease related to ageing 6 , decreased ocular blood flow 7 , mitochondrial dysfunction 8 , and oxidative stress 9 . Our previous research has revealed that biological antioxidant potential (BAP), a systemic measure of antioxidative potential, is associated with disease severity in younger male glaucoma patients 10 .…”

mentioning

confidence: 99%

The association between oxidative stress and corneal hysteresis in patients with glaucoma

Uchida

Himori

Hashimoto

et al. 2020

Sci Rep

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Systemic antioxidative status has been implicated in glaucoma pathogenesis. Additionally, corneal hysteresis (cH) may contribute to glaucoma progression. Here, we evaluated the relationship between biological antioxidant potential (BAP) and CH. This study included 103 patients with open-angle glaucoma (oAG). We used a free radical analyzer to measure BAp, and an ocular response analyzer to measure cH and corneal resistance factor (cRf). We evaluated the relationship between systemic oxidative stress and other clinical parameters with Spearman's rank correlation test and a multiregression analysis. BAp was not correlated to either cH or cRf in the male or female oAG patients. BAP was correlated to both CH and CRF in the female OAG patients older than 57 years (r = 0.51, P = 0.003; r = 0.49, P = 0.004), but uncorrelated in the female OAG patients younger than 57 years. Multiple regression analysis revealed that BAp independently contributed to cH (P = 0.025) and CRF (P = 0.015) in the older female OAG patients. Systemic oxidative stress may significantly affect the viscoelasticity of the cornea in older female OAG patients. Future studies are needed to confirm that low systemic antioxidative status and low corneal hysteresis contribute to glaucoma pathogenesis.

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The association between skin autofluorescence and mean deviation in patients with open-angle glaucoma

Abstract: We found that the relationship between systemic oxidative stress and visual field loss was strongest in relatively young patients with OAG, suggesting that the potential benefit of antioxidant therapies to combat systemic oxidative stress might be dependent on the age of the patient.

Cited by 8 publications

References 22 publications

Advanced Glycation End Product Accumulation in Subjects with Open-Angle Glaucoma with and without Exfoliation

Advanced Glycation End Product Accumulation in Subjects with Open-Angle Glaucoma with and without Exfoliation

Autofluorescence of Skin Advanced Glycation End Products as a Risk Factor for Open Angle Glaucoma: The ALIENOR Study

The association between oxidative stress and corneal hysteresis in patients with glaucoma

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