The association between oxidative stress and corneal hysteresis in patients with glaucoma

Abstract

Systemic antioxidative status has been implicated in glaucoma pathogenesis. Additionally, corneal hysteresis (cH) may contribute to glaucoma progression. Here, we evaluated the relationship between biological antioxidant potential (BAP) and CH. This study included 103 patients with open-angle glaucoma (oAG). We used a free radical analyzer to measure BAp, and an ocular response analyzer to measure cH and corneal resistance factor (cRf). We evaluated the relationship between systemic oxidative stress and other clinical parameters with Spearman's rank correlation test and a multiregression analysis. BAp was not correlated to either cH or cRf in the male or female oAG patients. BAP was correlated to both CH and CRF in the female OAG patients older than 57 years (r = 0.51, P = 0.003; r = 0.49, P = 0.004), but uncorrelated in the female OAG patients younger than 57 years. Multiple regression analysis revealed that BAp independently contributed to cH (P = 0.025) and CRF (P = 0.015) in the older female OAG patients. Systemic oxidative stress may significantly affect the viscoelasticity of the cornea in older female OAG patients. Future studies are needed to confirm that low systemic antioxidative status and low corneal hysteresis contribute to glaucoma pathogenesis.

Association between Systemic Antioxidant Capacity and Retinal Vessel Diameters in Patients with Primary-Open Angle Glaucoma

“…The second clinical suggestion we provided here is that significantly lower BAP was observed in patients with POAG, and lower BAP was independently related to narrower CRAE and CRVE in the multivariate analyses. Systemic oxidative stress including lower BAP has been thought to play an important role in the pathology of open-angle glaucoma [ 36 , 37 , 38 ]. We previously reported the significant correlation between BAP and IOP in patients with POAG, suggesting that lower systemic antioxidant capacity may be involved in the pathogenesis of glaucoma due to its impact on IOP elevation [ 39 ].…”

The Effect of Dietary Antioxidant Supplementation in Patients with Cataract and Glaucoma

“…Second, it disrupts autoregulation of blood ow to the optic nerve by altering the vessels that feed it [17,18]. Finally, patients with a low antioxidant level in the eye are susceptible to systemic oxidative stress, which can induce RGC death, as we have previously reported [19,20]. Harris Here, we gave a daily dietary antioxidant supplement over 8 weeks to patients with cataract and glaucoma.…”

“…Total plasma antioxidant capacity in the samples was measured with the BAP test, which is based on the ability of a sample to reduce iron from its ferric (Fe3+) to its ferrous (Fe2+) state. The analyses were performed as previously reported [19,20].…”

Taurine and oxidative stress in retinal health and disease

“…90,91 Like AMD, glaucoma is also associated with OS. 92,93 Indeed, it has been reported that the progressive loss of TM cells in glaucoma patients may be attributed to the long-term effects of oxidative injury induced by free radicals. 94,95 This hypothesis was then supported by in vitro and in vivo studies.…”