The association between sexually transmitted infections, human papillomavirus, and cervical cytology abnormalities among women in Greece

Parthenis, Christos; Panagopoulos, Periklis; Margari, Niki; Kottaridi, Christine; Spathis, Aris; Pouliakis, Abraham; Konstantoudakis, Stefanos; Chrelias, George; Chrelias, Charalambos; Papantoniou, Nikolaos; Panayiotides, Ioannis G.; Tsiodras, Sotirios

doi:10.1016/j.ijid.2018.06.001

Cited by 22 publications

(21 citation statements)

References 24 publications

(34 reference statements)

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“…and hrHPV is in line with a recent work among a population of healthy women undergoing screening for cervical cancer which showed that cervical hrHPV infection is significantly associated with codetection of Ureaplasma spp. at the same site with an odds ratio of 2.3, p = 0.02 (Parthenis et al, 2018). Our study is the first to evaluate co-existence of HPV and Ureaplasma spp.…”

Section: Discussionmentioning

confidence: 77%

“…In addition to facilitating HIV transmission, STIs including Ureaplasma spp. may co-exist with human papillomavirus (HPV) and may contribute significantly to the pathogenesis of HPVassociated dysplastic lesions in the cervix (Bellaminutti et al, 2014;Camporiondo et al, 2016;Liu et al, 2016;Verteramo et al, 2009;Kim et al, 2016;Parthenis et al, 2018;Biernat-Sudolska et al, 2008;Biernat-Sudolska et al, 2011;Lukic et al, 2006). Since HIV positive MSM have a particularly high prevalence of anal HPV infection, understanding the extent of Ureaplasma spp.…”

Section: Introductionmentioning

confidence: 99%

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Anal Ureaplasma spp. positivity among HIV positive men who have sex with men may be associated with high-risk-type HPV infections

Borena

Kruis

Kitchen

et al. 2019

International Journal of Infectious Diseases

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Objective: HIV positive individuals, particularly men having sex with men (MSM), are at increased risk of sexually transmitted infections (STIs) at genital and extra-genital sites. Data on anorectal Ureaplasma infections are lacking. The aim of our study was to characterize anal Ureaplasma positivity among a cohort of HIV positive MSM and evaluate possible association with papillomavirus infection at the same site. Methods: Anal swab samples, collected as part of routine screening for Chlamydia trachomatis and Neisseria gonorrhea, were additionally tested for HPV genotypes as well as for Ureaplasma and Mycoplasma using nucleic acid amplification method. Results: Out of a total of 222 study participants, 195 (89%, 95% CI (84.9-93.2)) were positive for HPV, approximately three quarter being high-risk genotypes. Forty three individuals (19.4%,3)) harbored Ureaplasma spp. Infection with high-risk HPV types was significantly associated with copresence of Ureaplasma with an odds ratio (95% confidence-interval) of 2.59 (1.03-6.54), P = 0.04. Conclusion: Besides a high predominance of HPV infection, asymptomatic HIV positive MSM had a high prevalence of anal Ureaplasma positivity. Concomitant infections with high-risk HPV genotypes were common and statistically significant. The role of this co-existence as a potential risk factor for anal carcinogenesis needs further elucidation.

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Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Anal Ureaplasma spp. positivity among HIV positive men who have sex with men may be associated with high-risk-type HPV infections

Borena

Kruis

Kitchen

et al. 2019

International Journal of Infectious Diseases

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“…However, several recent studies investigating the role of cervical co-infections of Ureaplasma spp. and other STIs in association with hrHPV, have supposed that these could be possible cofactors interacting with HPV in the development of precancerous and cancerous cervical lesions [31][32][33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Human Papillomavirus (HPV) and Other Sexually Transmitted Infections (STIs) among Italian Women Referred for a Colposcopy

Martinelli

Musumeci

Sechi

et al. 2019

IJERPH

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Sexually transmitted infections (STIs) represent a major cause of morbidity in women and men worldwide. Human Papillomavirus (HPV) infections are among the most prevalent STIs and persistent infections with high-risk HPV (hrHPV) genotypes can cause cervical dysplasia and invasive cervical cancer. The association of other STIs with HPV cervical infection and/or dysplasia has however not yet been fully elucidated. The aim of this study was to assess the prevalence of HPV and other STIs among women presenting with an abnormal cervical cytology. Cervical infections with 28 HPV genotypes and seven other sexually transmitted pathogens were evaluated in 177 women referred for a colposcopy after an abnormal Pap smear. Positivity for at least one hrHPV genotype was shown in 87% of women; HPV 16 was the most prevalent (25.0%), followed by HPV 31 and HPV 51. The overall positivity for other STIs was 49.2%, with Ureaplasma parvum being the most prevalent microrganism (39.0%). Co-infections between hrHPV and other STIs were demonstrated in 17.5% of women; no significant association was demonstrated between multiple infections and the colposcopy findings. This study provides new epidemiological data on the prevalence of cervical infections associated with HPV and seven other common sexually transmitted pathogens in a population of women presenting with an abnormal cervical cytology.

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“…Previous studies reported that there are many other risk factors for SCC including long term use of oral contraceptives [4], high parity [5], cigarette smoking [6], co-infection with the human immunodeficiency virus [7], and sexually transmitted infections (STIs), such as Chlamydia trachomatis [8], Neisseria gonorrhoeae [9], herpes simplex virus type 2 [10,11], Trichomonas vaginalis [12], Mycoplasma [13], Ureaplasma species [14,15]. However, at present, there is no unanimous consensus on the impact of non-HPV STIs on abnormal cervical cytology.…”

Section: Introductionmentioning

confidence: 99%

Associations of sexually transmitted infections and bacterial vaginosis with abnormal cervical cytology: A cross-sectional survey with 9090 community women in China

Liu

Luo

et al. 2020

PLoS ONE

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Background Although it is well acknowledged that persistent infection with high-risk human papillomavirus types in genital sites plays a crucial role in the development of squamous cell cervical carcinoma, there is no unanimous consensus on the association between non-HPV sexually transmitted infections and abnormal cervical cytology. Methods In the present study, we evaluated cervical cytology status, sexually transmitted infections and bacterial vaginosis status, and collected social-demographic information among recruited participants to explore the association of STIs and bacterial vaginosis with abnormal cervical cytology. Results 9,090 women's specimens were successfully tested, with a total of 8,733 (96.1%) women had normal cytology and 357 (3.9%) women exhibited abnormal cytology. The prevalence of HPV, Chlamydia trachomatis, Neisseria gonorrhoeae, and bacterial vaginosis was significantly higher in the �ASC-US group than the NILM group (P<0.05). Women with Neisseria gonorrhoeae infection (AOR = 5.30, 95% CIs = 1.30-21.51, P = 0.020) or bacterial vaginosis (AOR = 1.94, 95% CIs = 1.08-3.47, P = 0.026) exhibited an increased risk of abnormal cervical cytology after adjusted for carcinogenic HPV-positive status.

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The association between sexually transmitted infections, human papillomavirus, and cervical cytology abnormalities among women in Greece

Abstract: In a population with a high prevalence of Ureaplasma spp, there was an association of this pathogen with high-risk HPV infection, a finding that needs further elucidation.

Cited by 22 publications

References 24 publications

Anal Ureaplasma spp. positivity among HIV positive men who have sex with men may be associated with high-risk-type HPV infections

Anal Ureaplasma spp. positivity among HIV positive men who have sex with men may be associated with high-risk-type HPV infections

Prevalence of Human Papillomavirus (HPV) and Other Sexually Transmitted Infections (STIs) among Italian Women Referred for a Colposcopy

Associations of sexually transmitted infections and bacterial vaginosis with abnormal cervical cytology: A cross-sectional survey with 9090 community women in China

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