Anal Ureaplasma spp. positivity among HIV positive men who have sex with men may be associated with high-risk-type HPV infections

Borena, Wegene; Kruis, Simon; Kitchen, Maria; Taylor, Ninon; Gisinger, Martin; Oberkofler, Hannes; Stoiber, Heribert; Zangerle, Robert; Laer, Dorotheé von; Sarcletti, Mario

doi:10.1016/j.ijid.2019.04.025

Cited by 5 publications

(5 citation statements)

References 38 publications

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“…HSV and CMV are known as the most frequent opportunistic infections among HIV-positive people, especially among MSM. It was previously shown by different authors HSV I/II and CMV coinfection in HIV-positive and HIV-negative MSM [26,27]. Our data revealed a lower rate of HSV 1 coinfection in HIV-positive MSM in comparison with those in HIV-negative MSM (HSV1: 1.7% vs. 5%), and CMV was detected only in the HIV-positive group.…”

Section: Discussionsupporting

confidence: 64%

The Prevalence of High Carcinogenic Risk of HPV Genotypes among HIV-Positive and HIV-Negative MSM from Russia

Beliakov¹,

Senina²,

Tyulenev³

et al. 2021

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Objective. Men who have sex with men (MSM) have a high risk of lifelong anal cancer caused by high-risk human papillomavirus (HR HPV) infections. The aim of this study was to investigate the prevalence of anal canal HR HPV infection among men who have sex with men (MSM) with and without HIV infection in Moscow (Russia). We evaluated associations of some HIV coinfections (HSV and CMV) and HPV distribution among MSM with and without HIV infection. Methods. Two groups of HIV-positive (n = 60) and HIV-negative (n = 60) MSM were evaluated in the study. Fourteen high-risk (HR) HPV types, HSV1/2, and CMV were investigated in men anal swabs. Results. HR HPVs were found with nearly the same frequency of 66.7% in both groups: HIV-positive and HIV-negative MSM. HIV-positive status was statistically associated with the presence of several (more than two) HPV types ( p = 0.044 ). The most prevalent HR HPV genotypes were HPV18, HPV16, HPV56, and HPV33 for HIV-positive MSM and HPV56, HPV51, HPV66, and HPV16 for HIV-negatives. We found a statistically significant association of five HR HPV types with HIV status of MSM: HPV16 ( p = 0.028 ), HPV18 ( p = 0.00006 ), HPV58 ( p = 0.003 ), HPV33 ( p = 0.019 ), and HPV39 ( p = 0.026 ). The frequency of HSV1 (1.7%) and HSV2 (10%) infections and CMV (3.3%) infection was evaluated in the group of HIV-positive MSM. The frequency of HSV1 (5%) and HSV2 (6.7%) infections and CMV (0%) infection was evaluated, as well, in the group of HIV-negative MSM. Conclusion. Multiple HPV genotypes were detected significantly more often than single HPV genotype in the group of HIV-positive MSM. According to our data, 25% of HIV-positive MSM have HPV39; this is the only one of the five types of HR HPV (16, 18, 58, 33, and 39) associated with this group of MSM that has not yet been included in the HPV vaccines available on the market.

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Section: Discussionsupporting

confidence: 64%

The Prevalence of High Carcinogenic Risk of HPV Genotypes among HIV-Positive and HIV-Negative MSM from Russia

Beliakov¹,

Senina²,

Tyulenev³

et al. 2021

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…Given the increasing incidence of HPV-associated OPC [41], the observed Ureaplasma spp. positivity exclusively among OPC patients in our study may be a non-negligible finding, particularly considering the fact that previous studies had found an association between Ureaplasma positivity and anogenital dysplasias [14].…”

Section: Non-hpv Sti and Oropharyngeal Carcinomacontrasting

confidence: 48%

“…Co-factors like smoking and immunosuppression were reported to play a meaningful role in the process of HPV-persistence [3,4]. Studies in the past reported that a co-existence of HPV with sexually transmitted infections (STIs) facilitates the persistence and dysplastic transformations of HPV-associated lesions in the cervix or the anus [5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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The Role of HPV and Non-HPV Sexually Transmitted Infections in Patients with Oropharyngeal Carcinoma: A Case Control Study

Kofler

Laimer

Bruckmoser³

et al. 2020

Cancers

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Background: Certain high-risk (hr) types of human papillomavirus (HPV) can cause cervical cancer in women and penile cancer in men. Hr-HPV can also cause cancers of the oropharynx and anus in both sexes. In the anal and cervical region, a contribution of co-infections with Ureaplasma spp. on the persistence of the hr-HPV infection by a profound inflammatory state is suggested. Here, we investigated if non-HPV sexually transmitted infections are associated with oropharyngeal carcinoma (OPC). Materials and Methods: In this case-control study, a brush test directly from the tumor surface of OPC patients (study group) and from the oropharynx of healthy volunteers (control group), both groups matching in age and sex, was performed. HPV subtypes were detected using a commercially available test kit. For non-HPV sexually transmitted infections (Ureaplasma spp., Chlamydia trachomatis, Mycoplasma hominis, and Mycoplasma genitalium), a multiplex nucleic acid amplification approach was performed. Results: In the study group, 96 patients (23 female/73 male), with histologically confirmed OPC and in the control group 112 patients (19 female/93 male), were included. Oropharyngeal hr-HPV-positivity was detected in 68% (65/96 patients) of the study group and 1.8% (2/112 patients) of the control group (p < 0.001). In three patients in the study group, Ureaplasma spp. was detected, whereas no patient was Ureaplasma spp. positive in the control group (p = 0.097). Chlamydia trachomatis, Mycoplasma hominis, and Mycoplasma genitalium were negative in both groups. Conclusion: Based on the current study, the prevalence of oropharyngeal Ureaplasma spp. among patients with OPC is low and does not support a role in oropharyngeal cancer. However, the detection of the pathogen only among OPC patients but not in the healthy individuals might indicate a potential role and needs further elucidation.

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“…Few cisgendered MSM receive screening for extragenital STIs (de Voux et al, 2019; Tuddenham et al, 2019). Additionally, the risk among PLWH-MSM for high-risk anal human papillomavirus genotypes are common (Borena et al, 2019) as are human papillomavirus infections in the oropharynx (Nakashima et al, 2014) and gonococcal antimicrobial resistance (Johnson Jones et al, 2019). The implications of missed screening opportunities are significant (Berry et al, 2010; Hoover et al, 2010; Patton et al, 2014).…”

Section: Problem Descriptionmentioning

confidence: 99%

A Quality Improvement Project Using Microlearning to Increase Provider Adherence to Extragenital Sexually Transmitted Infection Screening Guidelines in Men Who Have Sex With Men

Shihabuddin¹,

Leasure²,

Higuita³

et al. 2020

J Assoc Nurses AIDS Care

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The Centers for Disease Control and Prevention (CDC) recommend screening men who have sex with men who are living with HIV for sexually transmitted infections at appropriate extragenital contact sites for bacterial sexually transmitted infections. In an effort to increase provider adherence to CDC recommended guidelines at a Ryan White Clinic, microlearning educational sessions were used. A quality improvement project was designed to determine the rate of provider adherence to CDC guidelines pre/post microlearning sessions. Student t-test was used to compare the number of patients who received urine and extragenital screening to those who received urine-only screening, to before and after the microlearning sessions. The rate of extragenital screening significantly increased after the microlearning sessions (4/460 vs. 70/507, p , .0001). The rate of urine screening remained unchanged (p 5 1). Although extragenital screening significantly increased, it remained low. A decision tree in the electronic medical record to prompt providers to screen was developed.

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Anal Ureaplasma spp. positivity among HIV positive men who have sex with men may be associated with high-risk-type HPV infections

Cited by 5 publications

References 38 publications

The Prevalence of High Carcinogenic Risk of HPV Genotypes among HIV-Positive and HIV-Negative MSM from Russia

The Prevalence of High Carcinogenic Risk of HPV Genotypes among HIV-Positive and HIV-Negative MSM from Russia

The Role of HPV and Non-HPV Sexually Transmitted Infections in Patients with Oropharyngeal Carcinoma: A Case Control Study

A Quality Improvement Project Using Microlearning to Increase Provider Adherence to Extragenital Sexually Transmitted Infection Screening Guidelines in Men Who Have Sex With Men

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