The association between serum uric acid and asymptomatic intracranial arterial stenosis in middle-aged Koreans

Ahn, Joong Kyong; Hwang, Jiwon; Hwang, Jung Hye; Yoon, Wontae; Chung, Pil-Wook; Ryu, Seungho

doi:10.1016/j.numecd.2017.10.019

Cited by 10 publications

(14 citation statements)

References 32 publications

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“…Consistent with the previous studies, 30,31 uric acid was found to be an independent risk factor for incidence of extracranial carotid atherosclerosis in both genders in this study. Yet, we found hyper- 32,33 Higher SUA level was associated with increased risk of ICAS in middle-aged Korea females but not in males. 33 The ARIC Study also found the same gender specific effect on asymptomatic carotid atherosclerosis in white population.…”

Section: Discussioncontrasting

confidence: 66%

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Longitudinal association between serum uric acid levels and multiterritorial atherosclerosis

Song

Yao

et al. 2019

J Cellular Molecular Medi

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Multiterritorial atherosclerosis has dramatically increased annual risk of adverse cardiovascular events than atherosclerotic disease with single‐artery affected. Serum uric acid (SUA) is an important predictor of stroke and atherosclerosis; however, which is supported by few direct evidence based on cohort studies. A prospective cohort study including 2644 North Chinese adults aged ≥40 years was performed in 2010‐2012 to investigate the association between SUA and multiterritorial vascular stenosis. Hyperuricaemia was defined as SUA levels >6 and >7 mg/dL for males and females, respectively. All participants underwent twice transcranial Doppler (TCD) and bilateral carotid duplex ultrasound to evaluate intracranial artery stenosis (ICAS) and extracranial arterial stenosis (ECAS) and peripheral arterial disease (PAD) was determined by ankle‐brachial index (ABI) on January 2010 and January 2012 based on regular health check‐ups. The cumulative incidence of vascular stenosis was significantly higher in subjects with hyperuricaemia than in those without hyperuricaemia (54.1% vs. 34.7%, P < 0.001). The adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for new on‐set vascular stenosis due to hyperuricaemia and a 1‐mg/dL change in SUA level were 1.75 (1.32‐2.31) and 1.29 (1.21‐1.38), respectively. Furthermore, in the gender‐stratified analysis, the association between SUA levels and ICAS was statistically significant in males (OR: 2.02; 95% CI: 1.18‐3.46), but not females (OR: 0.85, 95% CI: 0.41‐1.76, P for interaction: 0.026).

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Section: Discussioncontrasting

confidence: 66%

“…Furthermore, the effect of SUA on ICAS was significant in men but not in women. 32,33 Higher SUA level was associated with increased risk of ICAS in middle-aged Korea females but not in males. 33 The ARIC Study also found the same gender specific effect on asymptomatic carotid atherosclerosis in white population.…”

Section: Discussionmentioning

confidence: 94%

Longitudinal association between serum uric acid levels and multiterritorial atherosclerosis

Song

Yao

et al. 2019

J Cellular Molecular Medi

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“…Elevated SUA concentration was significantly associated with proximal extracranial artery stenosis (PEAS) in the Chinese population [19]. A higher SUA level was associated with an increased risk of intracranial arterial stenosis (ICAS) among middle-aged females [20]. In addition, LDL-C is the principal target of lipid-lowering therapy to prevent carotid stenosis progression.…”

Section: Discussionmentioning

confidence: 99%

Serum Uric Acid and Triglycerides in Chinese Patients with Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study

Feng

et al. 2019

BioMed Research International

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Background. Evidence regarding the relationship between serum uric acid and triglycerides is limited. Therefore, the specific objective of this study was to investigate whether serum uric acid was independently related to triglycerides in Chinese patients with newly diagnosed moyamoya disease after adjusting for other covariates. Methods. The present study was a cross-sectional study. A total of 261 Chinese patients with newly diagnosed moyamoya disease were recruited from a hospital in China from 24 March 2013 to 24 December 2018. The independent variable and the dependent variable were serum uric acid measured at baseline and triglycerides, respectively. The covariates involved in this study included age, sex, body mass index, smoking status, and alcohol consumption. Results. The average age of the 227 selected participants was 47.5 ± 12.6 years old, and approximately 48.5% of them were male. The results of the fully adjusted linear regression showed that serum uric acid (10 μmol/L) was positively associated with triglycerides (mmol/L) after adjusting for confounders (β 0.048, 95% CI 0.032, 0.064). Conclusions. In patients with moyamoya disease, there seemed to be a positive association between serum uric acid and triglycerides.

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“…Kumral, Karaman, Orman, & Kabaroglu () demonstrated that higher uric acid level is strongly associated with carotid artery disease. In the article published by Ahn et al., () the authors reported that higher serum uric acid level was associated with an increased risk of intracranial arterial stenosis among middle‐aged females but not males. In our study, the uric acid level in females with MCA stenosis was higher than that in those without MCA stenosis, but no significant difference was observed.…”

Section: Discussionmentioning

confidence: 99%

“…Kumral, Karaman, Orman, & Kabaroglu (2014) demonstrated that higher uric acid level is strongly associated with carotid artery disease. In the article published by Ahn et al, (2018) the authors reported that higher serum uric acid level was associated with an increased risk of intracranial arterial stenosis among middle-aged females but not males.…”

Section: Discussionmentioning

confidence: 99%

Lack of association between serum homocysteine level and middle cerebral artery stenosis

et al. 2019

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Objectives Lowering homocysteine ( HCY ) has beneficial effects on vascular events in primary prevention but not in secondary prevention. Research on serum HCY level and middle cerebral artery ( MCA ) stenosis is lacking. The purpose of the study was to determine the association between these factors and provide more evidence for the prevention of ischemic stroke. Methods A total of 412 patients (35–93 years old) in the Neurology Department were recruited. Data of clinical and biochemical vascular risk factors were collected. MCA stenosis, including M1, M2, and M3, was determined by brain magnetic resonance angiography ( MRA ) and classified into stenosis or no stenosis. The differences and associations were analyzed by relevant statistical methods. Results There was no significant difference ( p = 0.325) in HCY levels between the MCA stenosis and no stenosis groups at baseline. Logistic regression analysis demonstrated that there was no significant association between HCY levels and MCA stenosis ( p = 0.447). After the two groups were matched for age and sex, there was still no difference ( p = 0.540 for males and 0.061 for females) or association ( p = 0.709 for males and 0.098 for females). In addition, we found that ischemic stroke was more prevalent in the MCA stenosis group and uric acid was higher in males with MCA stenosis. Conclusions The study indicates a lack of association between serum HCY level and MCA stenosis, which may partially explain the negative results of secondary prevention clinical trials focused on lowering serum HCY level. Future studies on HCY reduction should focus more on primary prevention of ischemic stroke.

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The association between serum uric acid and asymptomatic intracranial arterial stenosis in middle-aged Koreans

Cited by 10 publications

References 32 publications

Longitudinal association between serum uric acid levels and multiterritorial atherosclerosis

Longitudinal association between serum uric acid levels and multiterritorial atherosclerosis

Serum Uric Acid and Triglycerides in Chinese Patients with Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study

Lack of association between serum homocysteine level and middle cerebral artery stenosis

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