Longitudinal association between serum uric acid levels and multiterritorial atherosclerosis

Abstract

Multiterritorial atherosclerosis has dramatically increased annual risk of adverse cardiovascular events than atherosclerotic disease with single‐artery affected. Serum uric acid (SUA) is an important predictor of stroke and atherosclerosis; however, which is supported by few direct evidence based on cohort studies. A prospective cohort study including 2644 North Chinese adults aged ≥40 years was performed in 2010‐2012 to investigate the association between SUA and multiterritorial vascular stenosis. Hyperuricaemia was defined as SUA levels >6 and >7 mg/dL for males and females, respectively. All participants underwent twice transcranial Doppler (TCD) and bilateral carotid duplex ultrasound to evaluate intracranial artery stenosis (ICAS) and extracranial arterial stenosis (ECAS) and peripheral arterial disease (PAD) was determined by ankle‐brachial index (ABI) on January 2010 and January 2012 based on regular health check‐ups. The cumulative incidence of vascular stenosis was significantly higher in subjects with hyperuricaemia than in those without hyperuricaemia (54.1% vs. 34.7%, P < 0.001). The adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for new on‐set vascular stenosis due to hyperuricaemia and a 1‐mg/dL change in SUA level were 1.75 (1.32‐2.31) and 1.29 (1.21‐1.38), respectively. Furthermore, in the gender‐stratified analysis, the association between SUA levels and ICAS was statistically significant in males (OR: 2.02; 95% CI: 1.18‐3.46), but not females (OR: 0.85, 95% CI: 0.41‐1.76, P for interaction: 0.026).

Hyperuricemia Is Associated with Left Ventricular Dysfunction and Inappropriate Left Ventricular Mass in Chronic Kidney Disease

“…In a large cross-sectional study, Shankar et al reported that higher serum UA levels were associated with peripheral arterial disease (defined as ABI < 0.9) in the US general population [ 49 ]. In addition, Song et al reported that serum UA levels were associated with asymptomatic polyvascular stenosis, including peripheral arterial disease, in a prospective cohort study of 2644 adults [ 50 ]. Possible reasons for the difference between the results of the present study and previous studies are as follows.…”

Gender-Specific Association between Serum Uric Acid and Incident Fundus Arteriosclerosis in Chinese Population: A Retrospective Cross-Sectional Study

“…When the SUA level was above 5.2 mg/dl, arterial stiffness was increased in healthy Korean men 34 . Some longitudinal studies have shown that uric acid was a risk factor for arteriosclerosis, the relationship was www.nature.com/scientificreports www.nature.com/scientificreports/ more pronounced in men 35 . Shin's 21 and Tomiyama's 36 studies showed an insignificant relationship between uric acid and arterial stiffness in women with normal uric acid level.…”

“…Recently, studies have shown that with the increase of age, male individuals with higher SUA values had an accelerated increase in PWV, which was not related to major 37 . A prospective cohort study of adults in northern China aged 40 years and older showed that uric acid was associated with arteriosclerosis, but not in women 35 . Previous studies have shown that SUA was an independent risk factor for arteriosclerosis in women older than 55 years 1 , but our studies showed that there were not statistically significant in females.…”

Study of association of serum uric acid with albuminuria and carotid atherosclerosis in type 2 diabetes mellitus patients

“…In a prospective cohort study by Song M et al . [19] in north Chinese adult UA was found to be an independent risk factor for incidence of extracranial carotid atherosclerosis in both genders. Also José Carlos Arévalo-Lorido et al .…”