The association between secondhand smoke and childhood asthma: A systematic review and meta‐analysis

He, Zonglin; Wu, Hongzhen; Zhang, Siyu; Lin, Yuchen; Rui, Li; Xie, Lijie; Li, Zibo; Sun, Weiwei; Huang, Xinyu; Zhang, Casper J. P.; Ming, Wai‐Kit

doi:10.1002/ppul.24961

Cited by 44 publications

(41 citation statements)

References 66 publications

(150 reference statements)

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“…44 Not only postnatal but also prenatal exposure to tobacco smoke can affect lung function and asthma risk. 45 Several GSTs, notably GSTM1 and GSTP1, have been shown to modify the association between intrauterine smoke exposure and asthma risk, further demonstrating the importance of oxidative stress-related pathways in the development of asthma. 8 In a study of interactions between maternal smoking and maternal genotype of important antioxidant genes, no evidence was found for modification by maternal NFE2L2 genotype of the association between prenatal smoke exposure and later asthma prevalence and lung function.…”

Section: Discussionmentioning

confidence: 99%

“…Not only postnatal but also prenatal exposure to tobacco smoke can affect lung function and asthma risk 45 . Several GSTs, notably GSTM1 and GSTP1, have been shown to modify the association between intrauterine smoke exposure and asthma risk, further demonstrating the importance of oxidative stress‐related pathways in the development of asthma 8 .…”

Section: Discussionmentioning

confidence: 99%

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Second‐hand smoke and NFE2L2 genotype interaction increases paediatric asthma risk and severity

Johansson

Martin

et al. 2021

Clin Experimental Allergy

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Background: Second-hand smoke (SHS) exposure is associated with paediatric asthma, and oxidative stress is believed to play a role in mediating this association.The nuclear factor (erythroid-derived 2)-like 2 (NFE2L2) is important for the defence against oxidative stress.Objective: To explore interactions between NFE2L2 genotype and SHS exposure in paediatric asthma risk. Methods:We used a genotyped subset of patients of European ancestry (N = 669, median age at enrolment = 6.8 years) enrolled in the clinical cohort Greater Cincinnati Pediatric Clinic Repository as the study population, and a population-based paediatric cohort (N = 791) to replicate our findings. History of asthma diagnosis was obtained from medical records, and SHS exposure was obtained from questionnaires. Four NFE2L2 tagging SNPs were included in the analysis, and interactions between SHS and NFE2L2 genotype were evaluated using logistic regression.Results: Three of the analysed SNPs, rs10183914, rs1806649 and rs2886161, interacted significantly with SHS exposure to increase asthma risk (p ≤ .02). The interaction was replicated in an independent cohort for rs10183914 (p = .04). Interactions between SHS exposure and NFE2L2 genotype were also associated with an increased risk of hospitalization (p = .016). In stratified analyses, NFE2L2 genotype was associated with daily asthma symptoms in children with SHS exposure (OR = 3.1; p = .048).No association was found in children without SHS exposure. Examination of publicly available chromatin immunoprecipitation followed by sequencing (ChIP-seq) data sets confirmed the presence of active histone marks and binding sites for particular transcription factors overlapping the coordinates for the significantly associated SNPs. Conclusions and Clinical Relevance:Our study provides evidence that NFE2L2 genotype interacts with SHS exposure to affect both asthma risk and severity in children and identifies a population of children at increased risk of asthma development.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Second‐hand smoke and NFE2L2 genotype interaction increases paediatric asthma risk and severity

Johansson

Martin

et al. 2021

Clin Experimental Allergy

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“… 3 There have been many meta-analyses trying to identify risk factors for asthma. Exposure to smoke, 4 male gender, atopic dermatitis, family history of asthma, history of wheezing and serum IgE level ≥60 kU/L or having specific IgE are found to be positively associated with developing asthma. 5 Breastfeeding 6 and exposure to cats and dogs 7 seem to play protective roles in the development of asthma.…”

Section: Introductionmentioning

confidence: 97%

Association between early bronchiolitis and the development of childhood asthma: a meta-analysis

et al. 2021

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ObjectiveEarly life bronchiolitis has been hypothesised to be associated with the subsequent risk of persistent wheezing or asthma. However, the link remains controversial. The objective of our study was to evaluate the association between bronchiolitis before 2 years of age and the late-onset wheezing/asthma.DesignSystematic review and meta-analysis.MethodsPubMed, Embase and Web of Science databases were systematically searched for studies published between 1955 and January 2020. Meanwhile, we also checked through the reference lists of relevant articles to see whether these references included reports of other studies that might be eligible for the review. Cohort and case–control studies assessing the association between early-life bronchiolitis and late-onset wheezing/asthma were included in this meta-analysis. Data were extracted by two independent reviewers. Results were pooled using a random-effects model or fixed-effects model according to the heterogeneity among studies.Results32 original articles with 292 844 participants, which met the criteria, were included in this meta-analysis. Bronchiolitis before 2 years of age was associated with an increased risk of subsequent wheezing/asthma (relative risk=2.46, 95% CI 2.14 to 2.82, p<0.001). After categorising studies into different groups based on age at the end of follow-up, geographical region and study quality, the association still remained significant.ConclusionsThe meta-analysis indicates an association between bronchiolitis before 2 years of age and the wheezing/asthma in later life. Well-designed and highly standardised prospective studies that better address bias due to potential confounding factors are needed to validate the risk identified in our meta-analysis.PROSPERO registration numberCRD42018089453.

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“…1 The negative impact of second-hand smoke on child health and development has been demonstrated in numerous studies, [2][3][4] especially on respiratory diseases. 5,6 The place where parents smoke has an impact on child tobacco smoke exposure. 7,8 Parental smoking is also a risk factor for subsequent active smoking in adolescence and young adulthood.…”

Section: Introductionmentioning

confidence: 99%

“…Reducing tobacco use is a major public health objective, with an estimated daily smoking prevalence in the French population of 24% in 2019 1 . The negative impact of second‐hand smoke on child health and development has been demonstrated in numerous studies, 2–4 especially on respiratory diseases 5,6 . The place where parents smoke has an impact on child tobacco smoke exposure 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Pediatrician intervention impacts parental smoking in cystic fibrosis, diabetes, and bronchiolitis

Lafont¹,

Morin

Arrouy

et al. 2021

Pediatric Pulmonology

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Background: Child exposure to cigarette smoke is harmful. It should be reduced through parental smoking cessation interventions. The aim of our study was to determine the impact of simple advice provided by the pediatrician on the smoking habits of parents of children with cystic fibrosis (CF), diabetes mellitus (DM), and infants hospitalized for bronchiolitis.Methods: Parents were interviewed on their smoking habits. Smoking cessation advice was provided by the pediatrician. A new smoking habits assessment was done at 3 months by phone interviews.Results: A total of 260 parents were interviewed (91 in the CF group, 136 in the DM group, and 33 in the bronchiolitis group). A total of 70 parents were active smokers: 33% of parents of children with CF, 23.5% of parents of children with DM, and 24.2% for those with infants hospitalized for bronchiolitis (p = .42). In the CF group, smoking cessation had been significantly more frequently discussed with the medical team previously. A total of 67 smoking parents (95.7%) answered the 3-month assessment: 29.8% reported having started a smoking cessation process; 10.4% had quit smoking. The quitting rate was significantly higher in the groups of patients followed for a respiratory disorder (37.5% for bronchiolitis, 15% for CF vs. 0% for DM, p = .005). Conclusion:This study shows the important role that information and simple advice from pediatricians can have in initiating smoking cessation in parents of patients followed in specialized clinics or who are hospitalized, with a greater efficiency in parents of patients suffering from lung disorders.

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The association between secondhand smoke and childhood asthma: A systematic review and meta‐analysis

Cited by 44 publications

References 66 publications

Second‐hand smoke and NFE2L2 genotype interaction increases paediatric asthma risk and severity

Second‐hand smoke and NFE2L2 genotype interaction increases paediatric asthma risk and severity

Association between early bronchiolitis and the development of childhood asthma: a meta-analysis

Pediatrician intervention impacts parental smoking in cystic fibrosis, diabetes, and bronchiolitis

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