The association between periodontal disease and adverse pregnancy outcomes in Northern Tanzania: a cross-sectional study

Gesase, Nyobasi; Miranda‐Rius, Jaume; Brunet‐Llobet, Lluís; Lahor-Soler, Eduard; Mahande, Michael Johnson; Masenga, Gileard

doi:10.4314/ahs.v18i3.18

Cited by 54 publications

(86 citation statements)

References 40 publications

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“…Women with high-titer active syphilis were at the greatest risk of having PTB (ARR 6.1 (2.5-15.3) [49]. Presence of periodontal disease (AOR 2.32; 95%CI: 1.33-4.27) [34] and periodontitis (at least three sites from different teeth with clinical attachment loss greater than or equal to4 mm [85] was significantly associated with PTB. Maternal depression increased the probability of having PTB (ARR 4.13; 95% CI: 2.82-17.42) [65].…”

Section: Medical Conditionsmentioning

confidence: 97%

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Determinants of preterm birth among mothers who gave birth in East Africa: systematic review and meta-analysis

Laelago¹,

Yohannes

Tsige

2020

Ital J Pediatr

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Background: Preterm birth (PTB) can be caused by different factors. The factors can be classified into different categories: socio demographic, obstetric, reproductive health, medical, behavioral and nutritional related. The objective of this review was identifying determinants of PTB among mothers who gave birth in East African countries. Methods: We have searched the following electronic bibliographic databases: PubMed, Google scholar, Cochrane library, AJOL (African journal online). Cross sectional, case control and cohort study published in English were included. There was no restriction on publication period. Studies with no abstracts and or full texts, editorials, and qualitative in design were excluded. Funnel plot was used to check publication bias. I-squared statistic was used to check heterogeneity. Pooled analysis was done by using fixed and random effect model. The Joanna Briggs Critical Appraisal Tools for review and meta-analysis was used to check the study quality. Results: A total of 58 studies with 134,801 participants were used to identify determinants of PTB. On pooled analysis, PTB was associated with age < 20 years (AOR 1.76, 95% CI: 1.33-2.32), birth interval less than 24 months (AOR 2.03, 95% CI 1.57-2.62), multiple pregnancy (AOR 3.44,95% CI: 3.02-3.91), < 4 antenatal care (ANC) visits (AOR 5.52, 95%

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Section: Medical Conditionsmentioning

confidence: 97%

“…The studies were included from 11 East African countries. Nineteen studies were from Tanzania [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51]…”

Section: Study Characteristicsmentioning

confidence: 99%

Determinants of preterm birth among mothers who gave birth in East Africa: systematic review and meta-analysis

Laelago¹,

Yohannes

Tsige

2020

Ital J Pediatr

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“…The prevalence of periodontal disease among pregnant women varies in different populations [11][12][13]. Moreover, several factors such as age, parity, lower level of education and anaemia were identified as risk factors for periodontal disease during pregnancy [4,14].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of and risk factors for periodontal disease among pregnant women in an antenatal care clinic in Khartoum, Sudan

et al. 2020

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Objectives: The aim was to investigate the prevalence of and factors associated with periodontal disease among pregnant Sudanese women. A cross-sectional study was conducted at the Antenatal Care Clinic of Saad Abualila Hospital (Khartoum, Sudan) from August to October 2018. Socioeconomic-demographic information and reproductive history were gathered using a questionnaire. Body mass index was computed from the weight and height. The diagnosis of periodontal disease was performed using criterion that also evaluated bleeding upon probing. Results: Four hundred and four women were enrolled in the study, with a mean (SD) gestational age of 30.0 (8.7) weeks. Their mean (SD) age and parity were 27.0 (5.7) years and 1.6 (1.7), respectively. Ninety-seven (24.0%) of these 404 women had periodontal disease, which was mild, moderate and severe in 49 (12.1%), 36 (8.9%) and 12 (3.0%) women respectively, while 307 (76.0%) women had no periodontal disease. In logistic regression, age, parity, education, and brushing were not associated with periodontitis, but lower gestational age was associated with periodontal disease (OR = 0.96, 95% CI 0.94-0.99, P = 0.011).

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“…The association between CP and LBW was rst reported by Offenbacher et al [1]. Many epidemiological studies have reported that pregnant women with CP are several times more likely than women without CP to have a preterm LBW infant [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Additionally, some studies have found that treatment for periodontitis is effective for preventing LBW [45][46][47][48].…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenic bacterium of CP and chemical mediators produced by in ammation in gingiva were considered to penetrate into weak capillary blood vessels, and then to cord blood through the placenta [2][3][4]. Some researchers have reported that CP in uences the development of LBW [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22], whereas others have denied such an association [23][24][25][26][27]. Therefore, no consensus has been reached on the association between CP and LBW [28][29][30][31], and more studies are needed to address this issue.…”

Section: Introductionmentioning

confidence: 99%

Potential Common Key Genes Associated with Chronic Periodontitis and Low Birth Weight: A Case Control Study Using Bioinformatics Analysis of Pooled mRNA Expression Datasets

Suzuki

Horie

Nakai³

et al. 2020

Preprint

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Background: Chronic periodontitis (CP) is a multifactorial disease associated with many systemic diseases. However, the precise association between CP and low birth weight (LBW) remains unclear. Therefore, this study aimed to elucidate common differentially expressed genes (DEGs), biomarker candidates, and upstream regulators related to key genes between CP and LBW.Methods: We investigated molecular relations and biomarker candidates using pooled microarray datasets of CP (GSE12484) and LBW (GSE29807) in the Gene Expression Omnibus (GEO). Datasets were analyzed for common DEGs using GEO2R, an R-based web application for GEO data analysis. Common DEGs, biomarker candidates, and upstream regulators in DEGs between CP and LBW were analyzed using the Database for Annotation Visualization and Integrated Discovery (DAVID), Search Tool for the Retrieval of Interacting Genes (STRING), and QIAGEN’s Ingenuity Pathway Analysis (IPA).Results: Three significantly upregulated and 20 significantly downregulated common DEGs between CP and LBW were identified. Some biological processes and pathways of these downregulated genes were associated with the cell cycle. Biomarker candidates among common DEGs were proline-rich coiled-coil 2A (PPRC2A), topoisomerase (DNA) II alpha (TOP2A), neural cell adhesion molecule 1 (NCAM1), and calcium channel, voltage-dependent, alpha 2/delta subunit 3 (CACNA2D3). Many upstream regulators of these biomarker candidates were factors associated with inflammation, immunity, the cell cycle, and growth development, and were hormones related to pregnancy.Conclusions: The results of this study suggest that PPRC2A, TOP2A, NCAM1, and CACNA2D3 are common biomedical key genes between CP and LBW. The expression states of these genes, which are related to inflammation, hormones, the cell cycle, and growth development, were common in both CP and LBW in blood. To the best of our knowledge, the relations of PPRC2A, TOP2A, and CACNA2D3 to CP and LBW are reported for the first time. Thus, in the bloodstream, inflammatory-related upstream regulators of these key genes may control gene expression associated with fetal growth, and conversely, changes in female hormones due to pregnancy may affect the progress of CP.

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The association between periodontal disease and adverse pregnancy outcomes in Northern Tanzania: a cross-sectional study

Abstract: Background: For the past two decades, studies have investigated the relationship between periodontal disease and adverse pregnancy outcomes such as pre-eclampsia, preterm birth, low birth weight and preterm premature rupture of membranes.

Cited by 54 publications

References 40 publications

Determinants of preterm birth among mothers who gave birth in East Africa: systematic review and meta-analysis

Determinants of preterm birth among mothers who gave birth in East Africa: systematic review and meta-analysis

Prevalence of and risk factors for periodontal disease among pregnant women in an antenatal care clinic in Khartoum, Sudan

Potential Common Key Genes Associated with Chronic Periodontitis and Low Birth Weight: A Case Control Study Using Bioinformatics Analysis of Pooled mRNA Expression Datasets

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