The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA-DR shared epitope and severity of bone destruction

Marotte, Hubert

doi:10.1136/ard.2005.036913

Cited by 144 publications

(110 citation statements)

References 15 publications

(13 reference statements)

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“…However, there is also a striking genetic similarity between the 2 diseases in that both are associated with the HLA SE alleles (46,47). This, together with the fact that P gingivalis is the only bacterium known to synthesize its own PAD enzyme (28), lends support to another hypothesis: that P gingivalis may be the "septic stimulus" in RA, as proposed by Rosenstein et al (42).…”

Section: Discussionmentioning

confidence: 91%

Antibodies to citrullinated α‐enolase peptide 1 are specific for rheumatoid arthritis and cross‐react with bacterial enolase

Lundberg

Kinloch

Fisher

et al. 2008

Arthritis & Rheumatism

339

313

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Objective. To map the antibody response to human citrullinated ␣-enolase, a candidate autoantigen in rheumatoid arthritis (RA), and to examine crossreactivity with bacterial enolase.Methods. Serum samples obtained from patients with RA, disease control subjects, and healthy control subjects were tested by enzyme-linked immunosorbent assay (ELISA) for reactivity with citrullinated ␣-enolase peptides. Antibodies specific for the immunodominant epitope were raised in rabbits or were purified from RA sera. Cross-reactivity with other citrullinated epitopes was investigated by inhibition ELISAs, and cross-reactivity with bacterial enolase was investigated by immunoblotting.Results. An immunodominant peptide, citrullinated ␣-enolase peptide 1, was identified. Antibodies to this epitope were observed in 37-62% of sera obtained from patients with RA, 3% of sera obtained from disease control subjects, and 2% of sera obtained from healthy control subjects. Binding was inhibited with homologous peptide but not with the arginine-containing control peptide or with 4 citrullinated peptides from elsewhere on the molecule, indicating that antibody binding was dependent on both citrulline and flanking amino acids. The immunodominant peptide showed 82% homology with enolase from Porphyromonas gingivalis, and the levels of antibodies to citrullinated ␣-enolase peptide 1 correlated with the levels of antibodies to the bacterial peptide (r 2 ‫؍‬ 0.803, P < 0.0001). Affinitypurified antibodies to the human peptide cross-reacted with citrullinated recombinant P gingivalis enolase.Conclusion. We have identified an immunodominant epitope in citrullinated ␣-enolase, to which antibodies are specific for RA. Our data on sequence similarity and cross-reactivity with bacterial enolase may indicate a role for bacterial infection, particularly with P gingivalis, in priming autoimmunity in a subset of patients with RA.

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Section: Discussionmentioning

confidence: 91%

Antibodies to citrullinated α‐enolase peptide 1 are specific for rheumatoid arthritis and cross‐react with bacterial enolase

Lundberg

Kinloch

Fisher

et al. 2008

Arthritis & Rheumatism

339

313

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“…RA occurs worldwide and it affects approximately 1% of the world population in a female/male ratio of 3:1 and has a peak incidence of onset in women in the fourth and fifth decades of life [7,8]. Although the aetiologies of these diseases are distinctly separate, the underlying pathological processes are of sufficient similarity, to warrant consideration of the hypothesis, that individuals at risk of developing rheumatoid arthritis may also be at risk of developing periodontitis, or vice versa [9][10][11][12]. In this sense, both conditions are associated with destruction of bone, mediated by inflammatory cytokines such as interleukin-1, tumoural necrosis factor and prostaglandin E2 [13].…”

Section: Introductionmentioning

confidence: 99%

Rheumatoid Arthritis among Periodontitis Patients in Baddi Industrial Estate of Himachal Pradesh, India: A Cross Sectional Study

Khuller²,

Patthi³

2013

JCDR

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“…First, the prevalence of periodontal disease (PD) is increased in RA (12)(13)(14), and the 2 conditions share clinical and histopathologic similarities as well as genetic (HLA-DR SE) and environmental (smoking) risk factors (15,16).…”

Section: Localized Autoimmunity: Initiating Events At Mucosal Surfacesmentioning

confidence: 99%

Review: Preclinical Rheumatoid Arthritis: Progress Toward Prevention

Mankia

Emery

2016

Arthritis & Rheumatology

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The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA-DR shared epitope and severity of bone destruction

Cited by 144 publications

References 15 publications

Antibodies to citrullinated α‐enolase peptide 1 are specific for rheumatoid arthritis and cross‐react with bacterial enolase

Antibodies to citrullinated α‐enolase peptide 1 are specific for rheumatoid arthritis and cross‐react with bacterial enolase

Rheumatoid Arthritis among Periodontitis Patients in Baddi Industrial Estate of Himachal Pradesh, India: A Cross Sectional Study

Review: Preclinical Rheumatoid Arthritis: Progress Toward Prevention

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