The association between parental mood/anxiety disorders and psychiatric symptoms and disorders in young adult offspring

Low, Nancy; Dugas, Erika N.; Constantin, Elena-Teodora; Karp, Igor; Rodríguez, Daniel; O’Loughlin, Julia I.

doi:10.1016/j.comppsych.2012.07.033

Comprehensive Psychiatry

2013

DOI: 10.1016/j.comppsych.2012.07.033

|View full text |Cite

The association between parental mood/anxiety disorders and psychiatric symptoms and disorders in young adult offspring

Nancy Low¹,

Erika N. Dugas²,

Elena-Teodora Constantin³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5,6 A 2-to 3-fold increased risk of MD has been identified among children and adolescents with at least 1 parent with MD compared with unexposed individuals. [7][8][9][10] Similarly, an increased risk of MD has been found between grandparents and grandchildren. [11][12][13] However, common to these studies is their relatively small sample size (range, 151-11 200 study individuals) and their sampling methods, often using probands to identify the study population, which may be limited by lack of representativeness to the general population.…”

mentioning

confidence: 99%

Association of Familial Aggregation of Major Depression With Risk of Major Depression

et al. 2023

View full text Add to dashboard Cite

ImportanceMajor depression (MD) aggregates within families, but how family history of MD confers risk of MD over the life course is unclear. Such knowledge is important to identify and prevent possible depressogenic effects of family environment.ObjectiveTo examine the association between family MD history and risk of MD including association with age, sex, type of kinship, and age of the affected family member.Design, Setting, and ParticipantsThis cohort study included all Danish citizens born from 1960 to 2003 with known parental identity followed up from their 15th birthday until time of MD, censoring, or December 31, 2018. Analysis took place between April 2022 and December 2022.ExposuresFamily members with first-time MD using International Classification of Diseases, Eighth Revision codes 296.09, 296.29, 298.09, and 300.49 or 10th Revision codes F32.0-F33.9, family members’ age at MD onset, and individuals’ age at exposure to family MDMain Outcomes and MeasuresMultivariable Poisson regression was applied to estimate the incidence rate ratio (IRR) with 95% CI of first-time MD.ResultsOf 2 903 430 individuals (1 486 574 [51.2%] men), 37 970 men (2.6%) and 70 223 women (5.0%) developed MD during follow-up. For men, exposure to maternal, paternal, or full sibling MD were associated with a 2-times higher risk of MD (IRR, 2.10 [95% CI, 2.02-2.19]; IRR, 2.04 [95% CI, 1.94-2.14]; IRR, 2.08 [95% CI, 1.97-2.19]) and the associated risk increased with number of affected family members. This pattern was similar for women. For men, family members’ age at MD onset was not associated with MD. For women, maternal MD onset at 69 years or younger was associated with higher IRRs of MD (age &lt;40 years: IRR, 1.64 [95% CI, 1.28-2.10]; age 40-49 years: IRR, 1.62 [95% CI, 1.27-2.07]; age 50-59 years: IRR, 1.56 [95% CI, 1.22-2.00]; and age 60-69 years: IRR, 1.67 [95% CI, 1.28-2.16]) compared with women with maternal MD onset at 70 years or older. For men, exposure to maternal MD younger than 30 years (age &lt;1 year: IRR, 1.95 [95% CI, 1.70-2.25]; age 1 to &lt;12 years: IRR, 2.31 [95% CI, 2.16-2.47]; age 12 to &lt;19 years: IRR, 2.18 [95% CI, 2.03-2.35]; age 19 to &lt;30 years: IRR, 1.42 [95% CI, 1.32-1.53]) was associated with increased IRRs, while exposure to maternal MD at 30 years or older was associated with a lower IRR (0.77 [95% CI, 0.70-0.85]). The findings were similar across type of kinships and for women.Conclusions and RelevanceIn this study, risk of MD was associated with increased numbers of affected family members but did not vary by gender or type of kinship. Exposure to family MD during childhood and adolescence was associated with increased risk.

show abstract

mentioning

confidence: 99%

Association of Familial Aggregation of Major Depression With Risk of Major Depression

et al. 2023

View full text Add to dashboard Cite

show abstract

Family History of Depression and Neural Reward Sensitivity: Findings From the Adolescent Brain Cognitive Development Study

Freeman

Olino

Barbeau

et al. 2023

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The association between parental mood/anxiety disorders and psychiatric symptoms and disorders in young adult offspring

Cited by 2 publications

References 0 publications

Association of Familial Aggregation of Major Depression With Risk of Major Depression

Association of Familial Aggregation of Major Depression With Risk of Major Depression

Family History of Depression and Neural Reward Sensitivity: Findings From the Adolescent Brain Cognitive Development Study

Contact Info

Product

Resources

About