The association between oxidative balance score and frailty in adults across a wide age spectrum: NHANES 2007–2018

Liu, Yan; Han, Yu; Gao, Yuqi; Yao, Nan; Wang, Yuxiang; Wang, Fengdan; Wu, Zibo; Dong, Yibo; Wang, Sizhe; Li, Bo

doi:10.1039/d4fo00870g

Food Funct.

2024

DOI: 10.1039/d4fo00870g

|View full text |Cite

The association between oxidative balance score and frailty in adults across a wide age spectrum: NHANES 2007–2018

Yan Liu,

Yu Han,

Yuqi Gao

et al.

Abstract: Frailty has been one of the most serious global public health challenges we will ever face.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Joint association of cardiovascular health and frailty with all-cause and cause-specific mortality: a prospective study

Ning,

Fan,

Zhang

et al. 2024

Age and Ageing

View full text Add to dashboard Cite

Background Poor cardiovascular health (CVH) and physical frailty were reported to increase mortality risk, but their joint effects have not been fully elucidated. Objectives We aimed to explore the separate and joint effects of CVH and frailty on mortality based on two perspectives of Life’s Essential 8 (LE8) and Framingham Risk Score (FRS). Methods 21 062 participants in the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018 were involved in this study. CVH was evaluated by the LE8 and FRS, and categorized into low, moderate and high CVH groups. Cox proportional hazard models were applied to estimate the separate and joint associations of CVH and frailty index (FI) with all-cause, cardiovascular disease (CVD) and cancer mortality. Results Over a median follow-up period of 87 months (95% CI: 86.0–88.0), 2036 deaths occurred. The separate linear dose–response relationships between CVH, frailty and mortality were observed (nonlinear P > .05). The combination of low CVH/frailty was negatively associated with all-cause mortality [hazard ratio (HR) and 95%CI: low LE8*FI, 5.30 (3.74, 7.52); high FRS*FI, 4.34 (3.20, 5.88)], CVD mortality [low LE8*FI, 6.57 (3.54, 12.22); high FRS*FI, 7.29 (3.92, 13.55)] and cancer mortality [low LE8*FI, 1.99 (1.14, 3.25); high FRS*FI, 2.32 (1.30, 4.15)], with high CVH/fit group as reference. Further stratified analyses showed that the combined burden of mortality from frailty and low CVH was greater among the young and females. Conclusions Low CVH and frailty were independently and jointly correlated with greater risk of all-cause, CVD and cancer deaths, especially among the young and females.

show abstract

Joint association of cardiovascular health and frailty with all-cause and cause-specific mortality: a prospective study

Ning,

Fan,

Zhang

et al. 2024

Age and Ageing

View full text Add to dashboard Cite

show abstract

Cross-sectional comparison of the association between three different insulin resistance surrogates and frailty: NHANES 1999-2018

Lai,

Guan,

Chen

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundThe correlation between various insulin resistance surrogates and frailty remains under investigation in the scientific community.MethodsData from NHANES (1999-2018) were used. We utilized weighted binary logistic regression, trend tests, RCS analysis, and subgroup analysis to comprehensively assess the link between METS-IR, HOMA-IR, and TyG, and frailty risk.ResultsThe results revealed a significant positive association between high levels of METS-IR, HOMA-IR, and TyG with the risk of frailty in all models. Notably, in model 4, the highest quintile of METS-IR showed the strongest link (OR: 2.960, 95% CI: 2.219-3.949), with HOMA-IR (OR: 2.522, 95% CI: 1.927-3.301) following closely behind. Trend tests revealed a positive trend between METS-IR, HOMA-IR, and TyG with the risk of frailty (P for trend < 0.05). RCS analysis showed a linear relationship between METS-IR and the risk of frailty (P for nonlinearity > 0.05). In contrast, HOMA-IR and TyG exhibited a U-shaped nonlinear relationship (P for nonlinearity < 0.05).ConclusionThe research identified a linear association between METS-IR and frailty risk, whereas HOMA-IR and TyG displayed a U-shaped, nonlinear relationship pattern with the risk of frailty. Among the varying levels examined, the linkage between METS-IR and frailty was most pronounced in the top quintile.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The association between oxidative balance score and frailty in adults across a wide age spectrum: NHANES 2007–2018

Abstract: Frailty has been one of the most serious global public health challenges we will ever face.

Cited by 2 publications

References 52 publications

Joint association of cardiovascular health and frailty with all-cause and cause-specific mortality: a prospective study

Joint association of cardiovascular health and frailty with all-cause and cause-specific mortality: a prospective study

Cross-sectional comparison of the association between three different insulin resistance surrogates and frailty: NHANES 1999-2018

Contact Info

Product

Resources

About