The Association Between Osteoporosis and Hypertension: The Role of A Low Dairy Intake

Varenna, M.; Manara, Maria Cristina; Galli, Laura; Binelli, L.; Zucchi, F.; Sinigaglia, Luigi

doi:10.1007/s00223-013-9731-9

Cited by 44 publications

(30 citation statements)

References 43 publications

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“…In view of the previous epidemiologic evidence that low dietary calcium intake significantly increases blood pressure 9,16,17 , this result could be understood as an effect of calcium homeostasis: theoretically a negative calcium balance could affect osteoporosis, hypertension and the otolith environment responsible for BPPV. An association between osteoporosis and hypertension was previously reported in postmenopausal women 18 . Those authors suggested that low dairy calcium intake might increase the risk of both diseases, acting as a possible pathogenic link 18 .…”

Section: Discussionmentioning

confidence: 74%

Increased risk of benign paroxysmal positional vertigo in osteoporosis: a nationwide population-based cohort study

Byun

Chung

Lee

et al. 2019

Sci Rep

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Benign paroxysmal positional vertigo (BPPV) is the most common cause of peripheral vertigo, which results from dislodged vestibular otoliths. Because the otoliths are mainly composed of calcium carbonate, it has been suggested that BPPV may be associated with osteoporosis. We aimed to assess the incidence and recurrence of BPPV in osteoporosis patients using a nationwide population-based cohort study with matched control. We used the database of the National Health Insurance Service of Korea, a universal system covering all 50 million Koreans. Osteoporosis was defined as patients who underwent bone mineral density tests and visited a clinic three or more times between Jan 2004 and Dec 2006. A control cohort consisted of non-osteoporotic subjects socio-demographically matched in a ratio of 1:1. The incidence and recurrence of BPPV between Jan 2007 and Dec 2016 were evaluated. A total of 177,797 osteoporosis patients and the same number of matched controls were identified. The incidence rates (IR) of BPPV in the osteoporosis patients and controls were 31.58 and 18.09 per 1000 persons, respectively (ratio of IR, IRR = 1.75, 95% CI 1.67–1.83). The IRs of recurrent BPPV were 187.3/1000 in the osteoporosis, 163.5/1000 in the controls (IRR = 1.15, 95% CI 1.02–1.28). In multivariate analysis, osteoporosis, female gender (adjusted HR = 1.76), age <65 (adjusted HR = 0.8), living in a metropolis, earning more than the lowest income and hypertension were significantly associated with increased risk of BPPV development. For recurrence, osteoporosis was the only meaningful risk factor (adjusted HR = 1.12). In conclusion, the risks of BPPV development and recurrence are higher in osteoporosis. Physicians might consider informing osteoporosis patients of the risk of developing BPPV and related falls.

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Section: Discussionmentioning

confidence: 74%

Increased risk of benign paroxysmal positional vertigo in osteoporosis: a nationwide population-based cohort study

Byun

Chung

Lee

et al. 2019

Sci Rep

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“…Several meta-analyses of randomised controlled trials have also indicated that Ca supplementation can lead to a small reduction in systolic and diastolic blood pressure; therefore, Ca supplements might be beneficial in patients with hypertension (125,126) . Varenna et al (127) have confirmed an association between hypertension and osteoporosis. There is a higher prevalence of hypertension in women with osteoporosis and a higher prevalence of osteoporosis in women with hypertension.…”

Section: Dietary Calciummentioning

confidence: 91%

Dietary and pharmacological compounds altering intestinal calcium absorption in humans and animals

et al. 2015

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The intestine is the only gate for the entry of Ca to the body in humans and mammals. The entrance of Ca occurs via paracellular and intracellular pathways. All steps of the latter pathway are regulated by calcitriol and by other hormones. Dietary and pharmacological compounds also modulate the intestinal Ca absorption process. Among them, dietary Ca and P are known to alter the lipid and protein composition of the brush-border and basolateral membranes and, consequently, Ca transport. Ca intakes are below the requirements recommended by health professionals in most countries, triggering important health problems. Chronic low Ca intake has been related to illness conditions such as osteoporosis, hypertension, renal lithiasis and incidences of human cancer. Carbohydrates, mainly lactose, and prebiotics have been described as positive modulators of intestinal Ca absorption. Apparently, high meat proteins increase intestinal Ca absorption while the effect of dietary lipids remains unclear. Pharmacological compounds such as menadione, dl-butionine-S,R-sulfoximine and ursodeoxycholic acid also modify intestinal Ca absorption as a consequence of altering the redox state of the epithelial cells. The paracellular pathway of intestinal Ca absorption is poorly known and is under present study in some laboratories. Another field that needs to be explored more intensively is the influence of the gene × diet interaction on intestinal Ca absorption. Health professionals should be aware of this knowledge in order to develop nutritional or medical strategies to stimulate the efficiency of intestinal Ca absorption and to prevent diseases.

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“…16 BMD was measured for all subjects at the proximal femur and lumbar spine (L1-L4) with a coefficient of variation of 0.8% and < 1.2%, respectively. It was expressed in g/cm 2 and as peak bone mass percentage in normal subjects (T-score). BMD results for the femoral neck and lumbar spine were classified into 3 groups according to World Health Organization criteria: normal (T-score > −1.0 SD), OP (T-score −1.0 to −2.5 SD) and OS (T-score < −2.5 SD).…”

Section: Measurement Of Body Composition By Dual-energy X-ray Absorptmentioning

confidence: 99%

Does Subjective Sleep Affect Bone Mineral Density in Older People with Minimal Health Disorders? The PROOF Cohort

Martin

Labeix

Garet

et al. 2016

Journal of Clinical Sleep Medicine

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Study Objectives: Clinical and epidemiological studies suggest a relation between bone mineral density (BMD) and self-assessment of sleep with an effect on bone formation and osteoporosis (OS) risk in short and long sleepers. This study explores this association in a large sample of older subjects. Methods: We examined 500 participants without insomnia complaints aged 65.7 ± 0.8 y. Each participant had a full evaluation including anthropometric measurement, clinical examination and measurements of BMD at the lumbar spine and femoral sites by dual-energy X-ray absorptiometry. The daily energy expenditure (DEE) was measured by the Population Physical Activity Questionnaire. Sleep duration and quality were evaluated by the Pittsburgh Sleep Quality Index. The subjects were stratified into three groups according to sleep duration, i.e., short (< 6 h), normal (6-8 h), and long (≥ 8 h) sleepers. Results: Osteopenia was found in 40% of the subjects at the femoral level and 43% at the vertebral level. The prevalence of OS was lower both at femoral (8%) and vertebral (12%) levels. Short, normal, and long sleepers accounted for 29%, 40%, and 31% of subjects, respectively. After adjustments for metabolic, anthropometric, and DEE, multinomial logistic regression analysis indicated that long sleepers were more likely to have femoral neck OS with a slight effect of DEE at vertebral spine. Conclusions: In a sample of older subjects, self-reported long sleep was the best predictor of OS risk at the femoral level. This finding suggests an association between OS and self-reported sleep duration in older subjects. Clinical Trial Registration: NCT 00759304 and NCT 00766584 Keywords: sleep duration, sleep quality, osteoporosis, bone mineral density, older people Citation: Saint Martin M, Labeix P, Garet M, Thierry T, Barthélémy JC, Collet P, Roche F, Sforza E. Does subjective sleep affect bone mineral density in older people with minimal health disorders? The PROOF cohort.

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The Association Between Osteoporosis and Hypertension: The Role of A Low Dairy Intake

Cited by 44 publications

References 43 publications

Increased risk of benign paroxysmal positional vertigo in osteoporosis: a nationwide population-based cohort study

Increased risk of benign paroxysmal positional vertigo in osteoporosis: a nationwide population-based cohort study

Dietary and pharmacological compounds altering intestinal calcium absorption in humans and animals

Does Subjective Sleep Affect Bone Mineral Density in Older People with Minimal Health Disorders? The PROOF Cohort

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