The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma‐glutamyl transferase in adult women

Jalili, Vahideh; Poorahmadi, Zohreh; Ardekanizadeh, Naeemeh Hasanpour; Ajami, Marjan; Houshiarrad, Anahita; Hajipour, Azadeh; Shafie, Fatemeh; Alizadeh, Atiyeh; Mokhtari, Zohreh; Shafaei, Hanieh; Esmaeili, Mina; Doaei, Saeid

doi:10.1002/edm2.367

Cited by 17 publications

(12 citation statements)

References 36 publications

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“…In a 2015 study by Meguro et al, green tea extract was given to DIO zebrafish. The extract was revealed to have an anti-obesity effect, and this research also showed that a fat-rich diet with low amounts of protein and carbohydrates induced excessive body fat accumulation in zebrafish in ways that were similar to those that occur in mammals 39 . Using DIO zebrafish and mouse models, different research on the anti-obesity properties of Palmariamollis (PM) revealed that it could drastically lower visceral adiposity and hepatic steatosis 10 .…”

Section: Introductionsupporting

confidence: 52%

Anti-obesity effects of olivetol in adult zebrafish model induced by short-term high-fat diet

Reshma,

Tamilanban,

Chitra

et al. 2023

Sci Rep

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Obesity is a complex disease caused by various factors, and synthetic drugs used to treat it can have side effects. Natural compounds, such as olivetol, could be a promising alternative. Olivetol is a substance found in certain lichen species and has anti-inflammatory and anti-cancer properties. In this study, researchers conducted in-silico molecular docking studies and found that olivetol had significant binding affinity with receptors involved in obesity. They also investigated the effects of olivetol on a diet-induced obese zebrafish model and found that high doses of olivetol reduced excessive fat accumulation and triglyceride and lipid accumulation. The low dose of olivetol showed a significant reduction in liver enzymes' levels. However, the high dose of olivetol resulted in a significant increase in HMG-CoA levels. These results suggest that olivetol may be a promising anti-obesity agent for the treatment of hyperlipidemia-related disorders, but further research is necessary to understand its full effects on the body.

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Section: Introductionsupporting

confidence: 52%

Anti-obesity effects of olivetol in adult zebrafish model induced by short-term high-fat diet

Reshma,

Tamilanban,

Chitra

et al. 2023

Sci Rep

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“…In the current study, the antiobesity effects of the 1-deoxynojirimycin containing MA based diet on the reduction of weight and BCS score and improvement in blood-related parameters, such as AST and GGT, were investigated to explore the possible molecular mechanism and role of the gut microbiome in the treatment group. Among liver enzymes, especially GGT and oxidative stress are positively associated with obesity [ 34 ]. GGT is a known marker of liver dysfunction and reduction of GGT may have positive effect in number of liver associated diseases [ 35 – 37 ].…”

Section: Discussionmentioning

confidence: 99%

1-Deoxynojirimycin containing Morus alba leaf-based food modulates the gut microbiome and expression of genes related to obesity

Jaiswal,

Lee,

Chun

et al. 2024

BMC Vet Res

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Background Obesity is a serious disease with an alarmingly high incidence that can lead to other complications in both humans and dogs. Similar to humans, obesity can cause metabolic diseases such as diabetes in dogs. Natural products may be the preferred intervention for metabolic diseases such as obesity. The compound 1-deoxynojirimycin, present in Morus leaves and other sources has antiobesity effects. The possible antiobesity effect of 1-deoxynojirimycin containing Morus alba leaf-based food was studied in healthy companion dogs (n = 46) visiting the veterinary clinic without a history of diseases. Body weight, body condition score (BCS), blood-related parameters, and other vital parameters of the dogs were studied. Whole-transcriptome of blood and gut microbiome analysis was also carried out to investigate the possible mechanisms of action and role of changes in the gut microbiome due to treatment. Results After 90 days of treatment, a significant antiobesity effect of the treatment food was observed through the reduction of weight, BCS, and blood-related parameters. A whole-transcriptome study revealed differentially expressed target genes important in obesity and diabetes-related pathways such as MLXIPL, CREB3L1, EGR1, ACTA2, SERPINE1, NOTCH3, and CXCL8. Gut microbiome analysis also revealed a significant difference in alpha and beta-diversity parameters in the treatment group. Similarly, the microbiota known for their health-promoting effects such as Lactobacillus ruminis, and Weissella hellenica were abundant (increased) in the treatment group. The predicted functional pathways related to obesity were also differentially abundant between groups. Conclusions 1-Deoxynojirimycin-containing treatment food have been shown to significantly improve obesity. The identified genes, pathways, and gut microbiome-related results may be pursued in further studies to develop 1-deoxynojirimycin-based products as candidates against obesity.

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“…Interestingly, there is evidence of the heritability of aspartate aminotransferase [71], and it is classically considered a biomarker of liver disease [72], though it is a higher abundance that is considered indicative of decreased liver function. However, in a study done in obese women, the significance of the BMI and aspartate relative abundance disappeared after correcting for dietary intake [73]. Considering that many genome-wide associations of serum aspartate modified by BMI have been reported, but none on the FHIT gene [74], more investigations are necessary to determine the role of aminotransferase metabolites in the context of child obesity and diabetes risk.…”

Section: Discussionmentioning

confidence: 99%

Genotype-microbiome-metabolome associations in early childhood, and their link to BMI and childhood obesity

Aparicio,

Sun,

Gold

et al. 2023

Preprint

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The influence of genotype on defining the human gut microbiome has been extensively studied, but definite conclusions have not yet been found. To fill this knowledge gap, we leverage data from children enrolled in the Vitamin D Antenatal Asthma Reduction Trial (VDAART) from 6 months to 8 years old. We focus on a pool of 12 genes previously found to be associated with the gut microbiome in independent studies, establishing a Bonferroni corrected significance level of p-value < 2.29 × 10−6. We identified significant associations between SNPs in the FHIT gene (known to be associated with obesity and type 2 diabetes) and obesity-related microbiome features, and the children’s BMI through their childhood. Based on these associations, we defined a set of SNPs of interest and a set of taxa of interest. Taking a multi-omics approach, we integrated plasma metabolome data into our analysis and found simultaneous associations among children’s BMI, the SNPs of interest, and the taxa of interest, involving amino acids, lipids, nucleotides, and xenobiotics. Using our association results, we constructed a quadripartite graph where each disjoint node set represents SNPs in the FHIT gene, microbial taxa, plasma metabolites, or BMI measurements. Network analysis led to the discovery of patterns that identify several genetic variants, microbial taxa and metabolites as new potential markers for obesity, type 2 diabetes, or insulin resistance risk.

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The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma‐glutamyl transferase in adult women

Cited by 17 publications

References 36 publications

Anti-obesity effects of olivetol in adult zebrafish model induced by short-term high-fat diet

Anti-obesity effects of olivetol in adult zebrafish model induced by short-term high-fat diet

1-Deoxynojirimycin containing Morus alba leaf-based food modulates the gut microbiome and expression of genes related to obesity

Genotype-microbiome-metabolome associations in early childhood, and their link to BMI and childhood obesity

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