Anti-obesity effects of olivetol in adult zebrafish model induced by short-term high-fat diet

Abstract

Obesity is a complex disease caused by various factors, and synthetic drugs used to treat it can have side effects. Natural compounds, such as olivetol, could be a promising alternative. Olivetol is a substance found in certain lichen species and has anti-inflammatory and anti-cancer properties. In this study, researchers conducted in-silico molecular docking studies and found that olivetol had significant binding affinity with receptors involved in obesity. They also investigated the effects of olivetol on a diet-induced obese zebrafish model and found that high doses of olivetol reduced excessive fat accumulation and triglyceride and lipid accumulation. The low dose of olivetol showed a significant reduction in liver enzymes' levels. However, the high dose of olivetol resulted in a significant increase in HMG-CoA levels. These results suggest that olivetol may be a promising anti-obesity agent for the treatment of hyperlipidemia-related disorders, but further research is necessary to understand its full effects on the body.

Supplementation of a High-Fat Diet with Pentadecylresorcinol Increases the Representation of Akkermansia muciniphila in the Mouse Small and Large Intestines and May Protect against Complications Caused by Imbalanced Nutrition

“…Quick snacks and fast foods enriched with simple sugars, fats, and flavorings create the impression of satiety and food satisfaction. Although there is an assurance that only a prolonged high-fat/high-carbohydrate diet leading to obesity and other metabolic diseases can cause sustainable changes in host and gut microbiota metabolism, in recent years, additional evidence of the crucial influence of a short-term high-fat diet on the gut microbiota and host metabolism has appeared [ 17 , 23 , 24 , 25 ]. It is known that diet-induced changes in the gut microbiome occur rapidly (within days) [ 26 ].…”

“…For example, antioxidant [ 27 ], anti-inflammatory [ 28 ] and anticarcinogenic [ 29 ] effects have been demonstrated for alkylresorcinols with different side chain lengths [ 27 ]. In a recent study by Reshma et al, a short-term high-fat diet-induced obese zebrafish model was investigated, and pentylresorcinol was shown to protect against obesity by preventing excess fat accumulation [ 17 ]. In a mouse model of obesity induced by a high-fat diet, compared to an HFD, AR supplementation was also shown to significantly improve glucose homeostasis and restore the serum level of GLP-1 [ 16 ] and increase glucose tolerance and insulin sensitivity by suppressing liver lipid accumulation and intestinal cholesterol absorption [ 30 ].…”

“…Liu et al [ 16 ] showed that dietary AR supplementation significantly improved glucose tolerance and restored serum glucagon-like peptide 1 (GLP-1) levels in C57BL/6J mice fed HFD compared to those of the control group. In the study by Reshma et al [ 17 ], the effects of olivetol (pentylresorcinol) on a diet-induced obese zebrafish model were investigated. Researchers have shown that pentylresorcinol reduces excessive fat accumulation and triglyceride and lipid accumulation, thus exerting an antiobesity effect and demonstrating therapeutic potential for the treatment of hyperlipidemia-related disorders [ 17 ].…”

“…In the study by Reshma et al [ 17 ], the effects of olivetol (pentylresorcinol) on a diet-induced obese zebrafish model were investigated. Researchers have shown that pentylresorcinol reduces excessive fat accumulation and triglyceride and lipid accumulation, thus exerting an antiobesity effect and demonstrating therapeutic potential for the treatment of hyperlipidemia-related disorders [ 17 ]. Furthermore, 5-heptadecylresorcinol has been found to improve HFD-induced mitochondrial dysregulation in mouse skeletal muscle tissue [ 18 ].…”

Innovative high fat diet establishes a novel zebrafish model for the study of visceral obesity

“…Zebrafish, with their high degree of conservation in the distribution and formation of adipose tissue compared to mammals, are suitable for studying obesity in both larval and adult stages, making them a proper animal model for obesity research 17 . By administering a high-fat diet (HFD), researchers can induce a zebrafish model of obesity, facilitating the study of obesity pathogenesis and the screening of potential anti-obesity drug candidates 18 .…”